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Preoperative Evaluation for Lung Cancer Resection

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Part of the book series: Contemporary Medical Imaging ((CMI))

Abstract

Lung resection is the most effective available treatment for patients with early stage non-small cell lung cancer. However, surgical resection can lead to a decrease in lung function. Patients with lung cancer may have concomitant lung disease secondary to tobacco smoking and a low tolerance to further loss in lung function. The objective of the preoperative evaluation for lung cancer resection is to identify those individuals whose short- and long-term morbidity and mortality would be unacceptably high if lung resection were to occur. Pulmonary function measures including the forced expiratory volume in 1 s and the diffusing capacity for carbon monoxide are useful predictors of postoperative outcome. In patients with abnormal lung function, the assessment of exercise capacity can further clarify surgical risks. Those patients deemed high risk should be evaluated in a multidisciplinary setting with thoracic oncologic input prior to eliminating the option of surgery for cure. This chapter discusses the factors considered in the preoperative evaluation for lung resection and summarizes the available guidelines.

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References

  1. British Thoracic Society, Society of Cardiothoracic Surgeons of Great Britain and Ireland Working Party. Guidelines on the selection of patients with lung cancer for surgery. Thorax. 2001;56:89–108.

    Article  Google Scholar 

  2. Damhuis RA, Schutte PR. Resection rates and postoperative mortality in 7,899 patients with lung cancer. Eur Respir J. 1996;9:7–10.

    Article  PubMed  CAS  Google Scholar 

  3. Yellin A, Hill LR, Lieberman Y. Pulmonary resections in patients over 70 years of age. Isr J Med Sci. 1985;21:833–40.

    PubMed  CAS  Google Scholar 

  4. Harvey JC, Erdman C, Pisch J, Beattie EJ. Surgical treatment of non-small cell lung cancer in patients older than seventy years. J Surg Oncol. 1995;60:247–9.

    Article  PubMed  CAS  Google Scholar 

  5. Pagni S, Federico JA, Ponn RB. Pulmonary resection for lung cancer in octogenarians. Ann Thorac Surg. 1997;63:785–9.

    Article  PubMed  CAS  Google Scholar 

  6. Finlayson E, Fan Z, Birkmeyer J. Outcomes in octogenarians undergoing high-risk cancer operation: a national study. J Am Coll Surg. 2007;205:729–34.

    Article  PubMed  Google Scholar 

  7. Brock MV, Kim MP, Hooker CM, et al. Pulmonary resection in octogenarians with stage I nonsmall cell lung cancer. Ann Thorac Surg. 2004;77:271–7.

    Article  PubMed  Google Scholar 

  8. Port JL, Kent M, Korst RJ, et al. Surgical resection for lung cancer in the octogenarian. Chest. 2004;126:733–8.

    Article  PubMed  Google Scholar 

  9. Palma DA, Tyldesley S, Sheehan F, et al. Stage I non-small cell lung cancer (NSCLC) in patients aged 75 years and older: does age determine survival after radical treatment? J Thorac Oncol. 2010;5(6):818–24.

    Article  PubMed  Google Scholar 

  10. Motohiro A, Ueda H, Komatsu H, Yanai N, Mori T, National Chest Hospital Study Group for Lung Cancer. Prognosis of non-surgically treated, clinical stage I lung cancer patients in Japan. Lung Cancer. 2002;36:65–9.

    Article  PubMed  Google Scholar 

  11. McGarry RC, Song G, des Rosiers P, Timmerman R. Observation-only management of early stage, medically inoperable lung cancer: poor outcome. Chest. 2002;121(4):1155–8.

    Article  PubMed  Google Scholar 

  12. Boushy SF, Billig DM, North LB, Helgason AH. Clinical course related to preoperative and postoperative pulmonary function in patients with bronchogenic carcinoma. Chest. 1971;59(4):383–91.

    Article  PubMed  CAS  Google Scholar 

  13. Miller JI Jr. Physiologic evaluation of pulmonary function in the candidate for lung resection. J Thorac Cardiovasc Surg. 1993;105(2):347–51; discussion 351–2.

    Google Scholar 

  14. Wernly JA, DeMeester TR, Kirchner PT, Myerowitz PD, Oxford DE, Golomb HM. Clinical value of quantitative ventilation-perfusion lung scans in the surgical management of bronchogenic carcinoma. J Thorac Cardiovasc Surg. 1980;80(4):535–43.

    PubMed  CAS  Google Scholar 

  15. Colice GL, Shafazand S, Griffin JP, Keenan R, Bolliger CT, American College of Chest Physicians. Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: ACCP evidenced-based clinical practice guidelines (2nd edition). Chest. 2007;132(3 Suppl):161S–77S.

    Article  PubMed  Google Scholar 

  16. Wyser C, Stulz P, Soler M, et al. Prospective evaluation of an algorithm for the functional assessment of lung resection candidates. Am J Respir Crit Care Med. 1999;159(5 Pt 1):1450–6.

    Article  PubMed  CAS  Google Scholar 

  17. Ferguson MK, Little L, Rizzo L, et al. Diffusing capacity predicts morbidity and mortality after pulmonary resection. J Thorac Cardiovasc Surg. 1988;96(6):894–900.

    PubMed  CAS  Google Scholar 

  18. Markos J, Mullan BP, Hillman DR, et al. Preoperative assessment as a predictor of mortality and morbidity after lung resection. Am Rev Respir Dis. 1989;139(4):902–10.

    Article  PubMed  CAS  Google Scholar 

  19. Liptay MJ, Basu S, Hoaglin MC, et al. Diffusion lung capacity for carbon monoxide (DLCO) is an independent prognostic factor for long-term survival after curative lung resection for cancer. J Surg Oncol. 2009;100(8):703–7.

    Article  PubMed  Google Scholar 

  20. Bousamra M 2nd, Presberg KW, Chammas JH, et al. Early and late morbidity in patients undergoing pulmonary resection with low diffusion capacity. Ann Thorac Surg. 1996;62(4):968–74; discussion 974–5.

    Google Scholar 

  21. Smulders SA, Smeenk FW, Janssen-Heijnen ML, Postmus PE. Actual and predicted postoperative changes in lung function after pneumonectomy: a retrospective analysis. Chest. 2004;125(5):1735–41.

    Article  PubMed  Google Scholar 

  22. Zeiher BG, Gross TJ, Kern JA, Lanza LA, Peterson MW. Predicting postoperative pulmonary function in patients undergoing lung resection. Chest. 1995;108(1):68–72.

    Article  PubMed  CAS  Google Scholar 

  23. Mazzone PJ, Arroliga AC. Lung cancer: preoperative pulmonary evaluation of the lung resection candidate. Am J Med. 2005;118(6):578–83.

    Article  PubMed  Google Scholar 

  24. Giordano A, Calcagni ML, Meduri G, Valente S, Galli G. Perfusion lung scintigraphy for the prediction of postlobectomy residual pulmonary function. Chest. 1997;111(6):1542–7.

    Article  PubMed  CAS  Google Scholar 

  25. Wu MT, Pan HB, Chiang AA, et al. Prediction of postoperative lung function in patients with lung cancer: comparison of quantitative CT with perfusion scintigraphy. AJR Am J Roentgenol. 2002;178(3):667–72.

    Article  PubMed  Google Scholar 

  26. Ueda K, Kaneda Y, Sudoh M, et al. Role of quantitative CT in predicting hypoxemia and complications after lung lobectomy for cancer, with special reference to area of emphysema. Chest. 2005;128(5):3500–6.

    Article  PubMed  Google Scholar 

  27. Olsen GN, Block AJ, Tobias JA. Prediction of postpneumonectomy pulmonary function using quantitative macroaggregate lung scanning. Chest. 1974;66(1):13–6.

    Article  PubMed  CAS  Google Scholar 

  28. Pate P, Tenholder MF, Griffin JP, Eastridge CE, Weiman DS. Preoperative assessment of the high-risk patient for lung resection. Ann Thorac Surg. 1996;61(5):1494–500.

    Article  PubMed  CAS  Google Scholar 

  29. Bolliger CT, Jordan P, Soler M, et al. Exercise capacity as a predictor of postoperative complications in lung resection candidates. Am J Respir Crit Care Med. 1995;151(5):1472–80.

    Article  PubMed  CAS  Google Scholar 

  30. Holden DA, Rice TW, Stelmach K, Meeker DP. Exercise testing, 6-min walk, and stair climb in the evaluation of patients at high risk for pulmonary resection. Chest. 1992;102(6):1774–9.

    Article  PubMed  CAS  Google Scholar 

  31. Pierce RJ, Copland JM, Sharpe K, Barter CE. Preoperative risk evaluation for lung cancer resection: predicted postoperative product as a predictor of surgical mortality. Am J Respir Crit Care Med. 1994;150(4):947–55.

    Article  PubMed  CAS  Google Scholar 

  32. Wahi R, McMurtrey MJ, DeCaro LF, et al. Determinants of perioperative morbidity and mortality after pneumonectomy. Ann Thorac Surg. 1989;48(1):33–7.

    Article  PubMed  CAS  Google Scholar 

  33. Beckles MA, Spiro SG, Colice GL, Rudd RM, American College of Chest Physicians. The physiologic evaluation of patients with lung cancer being considered for resectional surgery. Chest. 2003;123(1 Suppl):105S–14S.

    Article  PubMed  Google Scholar 

  34. Bechard D, Wetstein L. Assessment of exercise oxygen consumption as preoperative criterion for lung resection. Ann Thorac Surg. 1987;44(4):344–9.

    Article  PubMed  CAS  Google Scholar 

  35. Olsen GN, Weiman DS, Bolton JW, et al. Submaximal invasive exercise testing and quantitative lung scanning in the evaluation for tolerance of lung resection. Chest. 1989;95(2):267–73.

    Article  PubMed  CAS  Google Scholar 

  36. Brunelli A, Belardinelli R, Refai M, et al. Peak oxygen consumption during cardiopulmonary exercise test improves risk stratification in candidates to major lung resection. Chest. 2009;135(5):1260–7.

    Article  PubMed  Google Scholar 

  37. Bolton JW, Weiman DS, Haynes JL, Hornung CA, Olsen GN, Almond CH. Stair climbing as an indicator of pulmonary function. Chest. 1987;92(5):783–8.

    Article  PubMed  CAS  Google Scholar 

  38. Pollock M, Roa J, Benditt J, Celli B. Estimation of ventilatory reserve by stair climbing. A study in patients with chronic airflow obstruction. Chest. 1993;104(5):1378–83.

    Article  PubMed  CAS  Google Scholar 

  39. Brunelli A, Refai M, Xiumé F, et al. Performance at symptom-limited stair-climbing test is associated with increased cardiopulmonary complications, mortality, and costs after major lung resection. Ann Thorac Surg. 2008;86(1):240–47; discussion 247–8.

    Google Scholar 

  40. Singh SJ, Morgan MD, Hardman AE, Rowe C, Bardsley PA. Comparison of oxygen uptake during a conventional treadmill test and the shuttle walking test in chronic airflow limitation. Eur Respir J. 1994;7(11):2016–20.

    PubMed  CAS  Google Scholar 

  41. Rao V, Todd TR, Kuus A, Buth KJ, Pearson FG. Exercise oximetry versus spirometry in the assessment of risk prior to lung resection. Ann Thorac Surg. 1995;60(3):603–8.

    Article  PubMed  CAS  Google Scholar 

  42. Fishman A, Martinez F, Naunheim K, et al. A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. N Engl J Med. 2003;348(21):2059–73.

    Article  PubMed  Google Scholar 

  43. National Emphysema Treatment Trial Research Group. Patients at high risk of death after lung-volume-reduction surgery. N Engl J Med. 2001;345(15):1075–83.

    Article  Google Scholar 

  44. Bluman LG, Mosca L, Newman N, Simon DG. Preoperative smoking habits and postoperative pulmonary complications. Chest. 1998;113(4):883–9.

    Article  PubMed  CAS  Google Scholar 

  45. Warner MA, Offord KP, Warner ME, et al. Role of preoperative cessation of smoking and other factors in postoperative pulmonary complications: a blinded prospective study of coronary artery bypass patients. Mayo Clin Proc. 1989;64(6):609–16.

    Article  PubMed  CAS  Google Scholar 

  46. Myers K, Hajek P, Hinds C, McRobbie H. Stopping smoking shortly before surgery and postoperative complications: a systematic review and meta-analysis. Arch Intern Med. 2011;171(11):983–9.

    Article  PubMed  Google Scholar 

  47. Barrera R, Shi W, Amar D, et al. Smoking and timing of cessation: impact on pulmonary complications after thoracotomy. Chest. 2005;127(6):1977–83.

    Article  PubMed  Google Scholar 

  48. Nakagawa M, Tanaka H, Tsukuma H, Kishi Y. Relationship between the duration of the preoperative smoke-free period and the incidence of postoperative pulmonary complications after pulmonary surgery. Chest. 2001;120(3):705–10.

    Article  PubMed  CAS  Google Scholar 

  49. Ries AL, Make BJ, Lee SM, et al. The effects of pulmonary rehabilitation in the national emphysema treatment trial. Chest. 2005;128(6):3799–809.

    Article  PubMed  Google Scholar 

  50. Handy Jr JR, Asaph JW, Skokan L, et al. What happens to patients undergoing lung cancer surgery? Outcomes and quality of life before and after surgery. Chest. 2002;122(1):21–30.

    Article  PubMed  Google Scholar 

  51. Brunelli A, Charloux A, Bolliger CT, et al. ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy). Eur Respir J. 2009;34(1):17–41.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Gerard A. Silvestri M.D., M.S. .

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Gomez, M., Shamblin, C.J., Silvestri, G.A. (2013). Preoperative Evaluation for Lung Cancer Resection. In: Ravenel, J. (eds) Lung Cancer Imaging. Contemporary Medical Imaging. Humana Press, New York, NY. https://doi.org/10.1007/978-1-60761-620-7_6

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  • DOI: https://doi.org/10.1007/978-1-60761-620-7_6

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-60761-619-1

  • Online ISBN: 978-1-60761-620-7

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