Abstract
As advances are made in the treatment of lung cancer with new chemotherapeutic regimens and agents, heightened awareness must be paid to the potential for drug-related lung injury. However, making the diagnosis of chemotherapy-induced lung injury is challenging, as it is nearly always a diagnosis of exclusion. Early detection of drug-related injury is critical as in many cases complete recovery will occur with removal of the offending agent. The combination of a high level of clinical suspicion, radiographic findings, and pathologic abnormalities all play a role in establishing a diagnosis of chemotherapy-related lung injury.
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References
Limper AH. Chemotherapy-induced lung disease. Clin Chest Med. 2004;25(1):53–64.
Limper AH. Drug-induced lung injury. In: Mason RJ, Broaddus VC, Murray JF, Nadel JA, editors. Murray and Nadel’s textbook of respiratory medicine. 4th ed. Philadelphia: Elsevier Saunders; 2005. p. 1888–908.
McAdams HP, Rosado-de-Christenson ML, Wehunt WD, Fishback NF. The alphabet soup revisited: the chronic interstitial pneumonias in the 1990s. Radiographics. 1996;16(5):1009–33.
Erasmus JJ, McAdams HP, Rossi SE. High-resolution CT of drug-induced lung disease. Radiol Clin North Am. 2002;40(1):61–72.
Allen JD. Drug-induced eosinophilic lung disease. Clin Chest Med. 2004;25(1):77–88.
Schwarz MI, Fontenot AP. Drug-induced diffuse alveolar hemorrhage syndromes and vasculitis. Clin Chest Med. 2004;25(1):133–40.
Machtay M. Pulmonary complications of anti-cancer treatment. In: Abeloff M, Armitage J, Niederhuber J, Kastan M, McKenna WG, editors. Clinical oncology. 3rd ed. Philadelphia: Elsevier Churchill Livingston; 2004. p. 1237–47.
Stinchcombe TE, Socinski MA. General aspects of chemotherapy. In: Detterbeck FC, Rivera MP, Socinski M, Rosenman J, editors. Diagnosis and treatment of lung cancer. 1st ed. Philadelphia: WB Saunders; 2001. p. 162–73.
Malik SW, Myers JL, DeRemee RA, Specks U. Lung toxicity with cyclophosphamide use: two distinct patterns. Am J Respir Crit Care Med. 1996;154(6 Pt 1):1851–6.
Brade WP, Herdrich K, Varini M. Ifosfamide: pharmacology, safety and therapeutic potential. Cancer Treat Rev. 1985;12(1):1–47.
Wang GS, Yang KY, Perng RP. Life-threatening hypersensitivity pneumonitis induced by docetaxel (taxotere). Br J Cancer. 2001;85(9):1247–50.
Reckzeh B, Merte H, Pflüger KH, Pfab R, Wolf M, Havemann K. Severe lymphocytopenia and interstitial pneumonia in patients treated with paclitaxel and simultaneous radiotherapy for non-small cell lung cancer. J Clin Oncol. 1996;14(4):1071–6.
Nelson R, Tarasoff P. Dyspnea with gemcitabine is commonly seen, often disease related, transient, and rarely severe. Eur J Cancer. 1995;31(A):S197–8.
Madarnas Y, Webster P, Shorter AM, Bjarnason GA. Irinotecan-associated pulmonary toxicity. Anticancer Drugs. 2000;11:709–13.
Maitland ML, Wilcox R, Hogarth DK, et al. Diffuse alveolar damage after a single dose of topotecan in a patient with pulmonary fibrosis and small cell lung cancer. Lung Cancer. 2006;54(2):243–5.
Rao SX, Ramaswamy G, Levin M, McCravey JW. Fatal acute respiratory failure after vinblastine-mitomycin therapy in lung carcinoma. Arch Intern Med. 1985;145(10):1905–7.
Castro M, Veeder MH, Mailliard JA, Tazelaar HD, Jett JR. A prospective study of pulmonary function in patients receiving mitomycin. Chest. 1996;109(4):939–44.
Linette DC, McGee KH, McFarland JA. Mitomycin-induced pulmonary toxicity: case report and review of the literature. Ann Pharmacother. 1992;26(4):481–4.
Sheldon R, Slaughter D. A syndrome of microangiopathic hemolytic anemia, renal impairment, and pulmonary edema in chemotherapy-treated patients with adenocarcinoma. Cancer. 1986;58(7):1428–36.
Cohen MH, Williams GA, Sridhara R, Chen G, Pazdur R. FDA drug approval summary: gefitinib (ZD1839)(Iressa) tablets. Oncologist. 2003;8(4):303–6.
ter Heine R, van den Bosch RTA, Schaefer-Prokop CM, et al. Fatal interstitial lung disease associated with high erlotonib and metabolite levels. A case report and a review of the literature. Lung Cancer. 2012;75(3):391–7.
Barber NA, Ganti AK. Pulmonary toxicities from targeted therapies: a review. Target Oncol. 2011;6(4):235–43.
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Cummings, K.W., Bhalla, S. (2013). Chemotherapy-Related Lung Injury. In: Ravenel, J. (eds) Lung Cancer Imaging. Contemporary Medical Imaging. Humana Press, New York, NY. https://doi.org/10.1007/978-1-60761-620-7_15
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DOI: https://doi.org/10.1007/978-1-60761-620-7_15
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