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Sensory Neuromodulators in Disorders with Delayed Gastric Emptying

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Gastroparesis

Part of the book series: Clinical Gastroenterology ((CG))

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Abstract

There is considerable overlap in clinical presentation between functional dyspeptic and vomiting syndromes associated with inherent delay in gastric emptying and neuromuscular dysfunction of gastric emptying mechanisms resulting in true gastroparesis. Symptomatic foregut disorders with delayed gastric emptying may respond to treatment with sensory neuromodulators. Tricyclic antidepressants are the agents used most often, and as many as three quarters of patients may demonstrate moderate symptom improvement. Systematic, large clinical trials using these agents do not exist, however, and much of the experience has been extracted from the use of sensory neuromodulators in overlapping functional syndromes. In this chapter, the role of sensory modulators in managing foregut symptoms is discussed, side effects are characterized, and guidelines for use are detailed.

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Author information

Authors and Affiliations

  1. Division of Gastroenterology, Washington University School of Medicine, St. Louis, MO, USA

    Gregory S. Sayuk MD, MPH (Assistant Professor of Medicine)

  2. Division of Gastroenterology, Washington University School of Medicine, St. Louis, MO, 63110, USA

    C. Prakash Gyawali MD, MRCP (Associate Professor of Medicine)

Authors
  1. Gregory S. Sayuk MD, MPH
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  2. C. Prakash Gyawali MD, MRCP
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Corresponding author

Correspondence to C. Prakash Gyawali MD, MRCP .

Editor information

Editors and Affiliations

  1. School of Medicine, Department of Medicine, Temple University, N. Broad St. 3401, Philadelphia, 19140, Pennsylvania, USA

    Henry P. Parkman

  2. Paul L Foster School of Medicine, Department of Internal Medicine, Texas Tech University Health Sciences Ce, Alberta Avenue 4800, El Paso, 77905, Texas, USA

    Richard W. McCallum

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Sayuk, G.S., Gyawali, C.P. (2012). Sensory Neuromodulators in Disorders with Delayed Gastric Emptying. In: Parkman, H., McCallum, R. (eds) Gastroparesis. Clinical Gastroenterology. Humana Press. https://doi.org/10.1007/978-1-60761-552-1_26

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  • DOI: https://doi.org/10.1007/978-1-60761-552-1_26

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-551-4

  • Online ISBN: 978-1-60761-552-1

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