Abstract
Gastroparesis is a common problem in preterm infants and adolescents and an infrequent condition in toddlers and school age children. Etiology, diagnosis, and treatment of gastroparesis differ in children compared to adults. Immaturity of the enteric nervous system is responsible for most cases of delayed gastric emptying in newborns and viral infections are the most common cause of gastroparesis in adolescents. While scintigraphy remains the gold standard for the diagnosis of gastroparesis in pediatrics, less invasive technologies, including ultrasonography and breath testing have been developed and validated to measure gastric emptying in children. Nutritional management, including the use of enteral feedings, is of paramount importance in pediatric gastroparesis. Scarce data is available in children to support the benefit of prokinetics, intrapyloric botulin toxin injection, or gastric pacemaker.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Lange A, Funch-Jensen P, Thommesen P, Schiotz PO. Gastric emptying patterns of a liquid meal in newborn infants measured by epigastric impedance. Neurogastroenterol Motil. 1997;9:55–62.
Riezzo G, Indrio F, Montagna O, Tripaldi C, Laforgia N, Chiloiro M, et al. Gastric electrical activity and gastric emptying in preterm newborns fed standard and hydrolysate formulas. J Pediatr Gastroenterol Nutr. 2001;33:290–5.
Ramirez A, Wong WW, Shulman RJ. Factors regulating gastric emptying in preterm infants. J Pediatr. 2006;149:475–9.
Ravelli AM, Milla PJ. Vomiting and gastroesophageal motor activity in children with disorders of the central nervous system. J Pediatr Gastroenterol Nutr. 1998;26:56–63.
Naftali T, Yishai R, Zangen T, Levine A. Post-infectious gastroparesis: clinical and electerogastrographic aspects. J Gastroenterol Hepatol. 2007;22:1423–8.
Sigurdsson L, Flores A, Putnam PE, Hyman PE, Di Lorenzo C. Postviral gastroparesis: presentation, treatment, and outcome. J Pediatr. 1997;131:751–4.
Friesen CA, Lin Z, Singh M, Singh V, Schurman JV, Burchell N, et al. Antral inflammatory cells, gastric emptying, and electrogastrography in pediatric functional dyspepsia. Dig Dis Sci. 2008;53:2634–40.
Cavell B. Gastric emptying in infants with cystic fibrosis. Acta Paediatr Scand. 1981;70:635–8.
Cucchiara S, Raia V, Minella R, Frezza T, De Vizia B, De Ritis G. Ultrasound measurement of gastric emptying time in patients with cystic fibrosis and effect of ranitidine on delayed gastric emptying. J Pediatr. 1996;128:485–8.
Schappi MG, Roulet M, Rochat T, Belli DC. Electrogastrography reveals post-prandial gastric dysmotility in children with cystic fibrosis. J Pediatr Gastroenterol Nutr. 2004;39:253–6.
Debinski HS, Ahmed S, Milla PJ, Kamm MA. Electrogastrography in chronic intestinal pseudoobstruction. Dig Dis Sci. 1996;41:1292–7.
Lange A, Funch-Jensen P, Schiotz PO. Gastric dysrhythmia in infants with gastrointestinal diseases measured by epigastric impedance. J Pediatr Gastroenterol Nutr. 2003;37:294–9.
Burghen GA, Murrell LR, Whitington GL, Klyce MK, Burstein S. Acid peptic disease in children with type I diabetes mellitus. A complicating relationship. Am J Dis Child. 1992;146:718–22.
Cucchiara S, Franzese A, Salvia G, Alfonsi L, Iula VD, Montisci A, et al. Gastric emptying delay and gastric electrical derangement in IDDM. Diabetes Care. 1998;21:438–43.
Reid B, DiLorenzo C, Travis L, Flores AF, Grill BB, Hyman PE. Diabetic gastroparesis due to postprandial antral hypomotility in childhood. Pediatrics. 1992;90:43–6.
White NH, Waltman SR, Krupin T, Santiago JV. Reversal of neuropathic and gastrointestinal complications related to diabetes mellitus in adolescents with improved metabolic control. J Pediatr. 1981;99:41–5.
Turchetti A, Guglielmi S, Fossati C, Matrunola M, Corrado G. Gastric emptying time in cyclic vomiting syndrome in children. Eur Rev Med Pharmacol Sci. 2004;8:295–8.
Chong SK. Electrogastrography in cyclic vomiting syndrome. Dig Dis Sci. 1999;44:64S–73S.
Cheng W, Chow B, Tam PK. Electrogastrographic changes in children who undergo day-surgery anesthesia. J Pediatr Surg. 1999;34:1336–8.
Au J, Hawkins T, Venables C, Morritt G, Scott CD, Gascoigne AD, et al. Upper gastrointestinal dysmotility in heart-lung transplant recipients. Ann Thorac Surg. 1993;55:94–7.
Alexander F, Wyllie R, Jirousek K, Secic M, Porvasnik S. Delayed gastric emptying affects outcome of Nissen fundoplication in neurologically impaired children. Surgery. 1997;122:690–7. discussion 697–8.
Dunn JC, Lai EC, Webber MM, Ament ME, Fonkalsrud EW. Long-term quantitative results following fundoplication and antroplasty for gastroesophageal reflux and delayed gastric emptying in children. Am J Surg. 1998;175:27–9.
Pacilli M, Pierro A, Lindley KJ, Curry JI, Eaton S. Gastric emptying is accelerated following laparoscopic Nissen fundoplication. Eur J Pediatr Surg. 2008;18:395–7.
Kamal N, Chami T, Andersen A, Rosell FA, Schuster MM, Whitehead WE. Delayed gastrointestinal transit times in anorexia nervosa and bulimia nervosa. Gastroenterology. 1991;101:1320–4.
Zimmerli EJ, Walsh BT, Guss JL, Devlin MJ, Kissileff HR. Gastric compliance in bulimia nervosa. Physiol Behav. 2006;87:441–6.
Perri F, Pastore M, Zicolella A, Annese V, Quitadamo M, Andriulli A. Gastric emptying of solids is delayed in celiac disease and normalizes after gluten withdrawal. Acta Paediatr. 2000;89:921–5.
Rocco A, Sarnelli G, Compare D, de Colibus P, Micheli P, Somma P, et al. Tissue ghrelin level and gastric emptying rate in adult patients with celiac disease. Neurogastroenterol Motil. 2008;20:884–90.
Singh SJ, Gibbons NJ, Blackshaw PE, Vincent M, Wakefield J, Perkins AC. Gastric emptying of solids in normal children – a preliminary report. J Pediatr Surg. 2006;41:413–7.
Abell TL, Camilleri M, Donohoe K, Hasler WL, Lin HC, Maurer AH, et al. Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. Am J Gastroenterol. 2008;103:753–63.
Cucchiara S, Minella R, Iorio R, Emiliano M, Az-Zeqeh N, Vallone G, et al. Real-time ultrasound reveals gastric motor abnormalities in children investigated for dyspeptic symptoms. J Pediatr Gastroenterol Nutr. 1995;21:446–53.
Chiloiro M, Caroli M, Guerra V, Lodadea Piepoli A, Riezzo G. Gastric emptying in normal weight and obese children – an ultrasound study. Int J Obes Relat Metab Disord. 1999;23:1303–6.
Gatti C, di Abriola FF, Dall’Oglio L, Villa M, Franchini F, Amarri S. Is the 13C-acetate breath test a valid procedure to analyse gastric emptying in children? J Pediatr Surg. 2000;35:62–5.
Chitkara DK, Camilleri M, Zinsmeister AR, Burton D, El-Youssef M, Freese D, et al. Gastric sensory and motor dysfunction in adolescents with functional dyspepsia. J Pediatr. 2005;146:500–5.
Kuo B, McCallum RW, Koch KL, Sitrin MD, Wo JM, Chey WD, et al. Comparison of gastric emptying of a nondigestible capsule to a radio-labelled meal in healthy and gastroparetic subjects. Aliment Pharmacol Ther. 2008;27:186–96.
Seimon RV, Feltrin KL, Meyer JH, Brennan IM, Wishart JM, Horowitz M, et al. Effects of varying combinations of intraduodenal lipid and carbohydrate on antropyloroduodenal motility, hormone release, and appetite in healthy males. Am J Physiol Regul Integr Comp Physiol. 2009;296:R912–20.
Jolliet P, Nion S, Allain-Veyrac G, Tilloy-Fenart L, Vanuxeem D, Berezowski V, et al. Evidence of lowest brain penetration of an antiemetic drug, metopimazine, compared to domperidone, metoclopramide and chlorpromazine, using an in vitro model of the blood-brain barrier. Pharmacol Res. 2007;56:11–7.
Takeda K, Taniyama K, Kuno T, Sano I, Ishikawa T, Ohmura I, et al. Clebopride enhances contractility of the guinea pig stomach by blocking peripheral D2 dopamine receptor and alpha-2 adrenoceptor. J Pharmacol Exp Ther. 1991;257:806–11.
Ahmad N, Keith-Ferris J, Gooden E, Abell T. Making a case for domperidone in the treatment of gastrointestinal motility disorders. Curr Opin Pharmacol. 2006;6:571–6.
Costalos C, Gounaris A, Varhalama E, Kokori F, Alexiou N, Kolovou E. Erythromycin as a prokinetic agent in preterm infants. J Pediatr Gastroenterol Nutr. 2002;34:23–5.
Mahon BE, Rosenman MB, Kleiman MB. Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. J Pediatr. 2001;139:380–4.
Cooper WO, Ray WA, Griffin MR. Prenatal prescription of macrolide antibiotics and infantile hypertrophic pyloric stenosis. Obstet Gynecol. 2002;100:101–6.
Goldstein LH, Berlin M, Tsur L, Bortnik O, Binyamini L, Berkovitch M. The safety of macrolides during lactation. Breastfeed Med. 2009;4:197–200.
Lee A, Fan LT. Stimulation of the wrist acupuncture point P6 for preventing postoperative nausea and vomiting. Cochrane Database Syst Rev. 2009:CD003281.
Friedenberg FK, Palit A, Parkman HP, Hanlon A, Nelson DB. Botulinum toxin A for the treatment of delayed gastric emptying. Am J Gastroenterol. 2008;103:416–23.
Hyman P, Schropp K, Sarosiek I, Forster J, Lin Z, Gertken J, et al. Feasibility and safety of gastric electrical stimulation for a child with intractable visceral pain and gastroparesis. J Pediatr Gastroenterol Nutr. 2009;49:635–8.
Islam S, Vick LR, Runnels MJ, Gosche JR, Abell T. Gastric electrical stimulation for children with intractable nausea and gastroparesis. J Pediatr Surg. 2008;43:437–42.
Waseem S, Moshiree B, Draganov PV. Gastroparesis: current diagnostic challenges and management considerations. World J Gastroenterol. 2009;15:25–37.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Saps, M., Di Lorenzo, C., Di Lorenzo, C. (2012). Pediatric Gastroparesis. In: Parkman, H., McCallum, R. (eds) Gastroparesis. Clinical Gastroenterology. Humana Press. https://doi.org/10.1007/978-1-60761-552-1_20
Download citation
DOI: https://doi.org/10.1007/978-1-60761-552-1_20
Published:
Publisher Name: Humana Press
Print ISBN: 978-1-60761-551-4
Online ISBN: 978-1-60761-552-1
eBook Packages: MedicineMedicine (R0)