Skip to main content
SpringerLink
Log in

Atopic and Allergic Features of Adults with Eosinophilic Esophagitis

  • Chapter
  • First Online:
Eosinophilic Esophagitis

Part of the book series: Clinical Gastroenterology ((CG))

  • 875 Accesses

Abstract

Allergen exposure has been well documented to have a role in the ­pathogenesis of pediatric eosinophilic esophagitis (EoE). A 1995 case series of pediatric patients demonstrated a dramatic clinical response to an elemental diet and subsequent clinical relapse upon reintroduction of foods. In the adult population, it has been hypothesized that allergen exposure plays a role in the pathophysiology of adult EoE, supported by high rates of personal and family history of atopy. Although published reports of successful resolution of clinical symptoms or eosinophilic infiltrates on biopsy as the result of food or aeroallergens identified through any of the above measures discussed are limited in adults, there is increasing evidence for a role for food and aeroallergens in the pathophysiology of adult EoE and a potential for future diagnostic and therapeutic implications.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Kelly KJ, Lazenby AJ, Rowe PC, Yardley JH, Perman JA, Sampson HA. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology. 1995;109(5):1503–12.

    Article  PubMed  CAS  Google Scholar 

  2. Markowitz JE, Spergel JM, Ruchelli E, Liacouras CA. Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents. Am J Gastroenterol. 2003;98(4): 777–82.

    Article  PubMed  CAS  Google Scholar 

  3. Putnam PE. Eosinophilic esophagitis in children: clinical manifestations. Gastrointest Endosc Clin N Am. 2008;18(1):11–23. vii.

    Article  PubMed  Google Scholar 

  4. Penfield JD, Lang DM, Goldblum JR, Lopez R, Falk GW. The role of allergy evaluation in adults with eosinophilic esophagitis. J Clin Gastroenterol. 2010;44(1):22–7.

    Article  PubMed  Google Scholar 

  5. Roy-Ghanta S, Larosa DF, Katzka DA. Atopic characteristics of adult patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2008;6(5):531–5.

    Article  PubMed  Google Scholar 

  6. Straumann A, Spichtin HP, Grize L, Bucher KA, Beglinger C, Simon HU. Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. Gastroenterology. 2003;125(6):1660–9.

    Article  PubMed  Google Scholar 

  7. Simon D, Marti H, Heer P, Simon HU, Braathen LR, Straumann A. Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseases. J Allergy Clin Immunol. 2005;115(5):1090–2.

    Article  PubMed  Google Scholar 

  8. Katzka DA. Demographic data and symptoms of eosinophilic esophagitis in adults. Gastrointest Endosc Clin N Am. 2008;18(1):25–32. viii.

    Article  PubMed  Google Scholar 

  9. Pasha SF, DiBaise JK, Kim HJ, et al. Patient characteristics, clinical, endoscopic, and histologic findings in adult eosinophilic esophagitis: a case series and systematic review of the medical literature. Dis Esophagus. 2007;20(4):311–9.

    Article  PubMed  CAS  Google Scholar 

  10. Assa’ad AH, Putnam PE, Collins MH, et al. Pediatric patients with eosinophilic esophagitis: an 8-year follow-up. J Allergy Clin Immunol. 2007;119(3):731–8.

    Article  PubMed  Google Scholar 

  11. Liacouras CA, Spergel JM, Ruchelli E, et al. Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol. 2005;3(12):1198–206.

    Article  PubMed  Google Scholar 

  12. Patel SM, Falchuk KR. Three brothers with dysphagia caused by eosinophilic esophagitis. Gastrointest Endosc. 2005;61(1):165–7.

    Article  PubMed  Google Scholar 

  13. Meyer GW. Eosinophilic esophagitis in a father and a daughter. Gastrointest Endosc. 2005;61(7):932.

    Article  PubMed  Google Scholar 

  14. Noel RJ, Putnam PE, Rothenberg ME. Eosinophilic esophagitis. N Engl J Med. 2004;351(9): 940–1.

    Article  PubMed  CAS  Google Scholar 

  15. Kagalwalla AF, Sentongo TA, Ritz S, et al. Effect of six-food elimination diet on clinical and ­histologic outcomes in eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2006;4(9):1097–102.

    Article  PubMed  Google Scholar 

  16. Simon D, Straumann A, Wenk A, Spichtin H, Simon HU, Braathen LR. Eosinophilic esophagitis in adults – no clinical relevance of wheat and rye sensitizations. Allergy. 2006;61(12):1480–3.

    Article  PubMed  CAS  Google Scholar 

  17. Gonsalves N. Food allergies and eosinophilic gastrointestinal illness. Gastroenterol Clin North Am. 2007;36(1):75–91. vi.

    Article  PubMed  Google Scholar 

  18. Gonsalves N, Yang G, Doerfler B, Ritz S, Ditto AM, Hirano I. 727 A Prospective Clinical Trial of Six Food Elimination Diet and Reintroduction of Causative Agents in Adults with Eosinophilic Esophagitis (EE). Gastroenterology. 2008;134(4 Suppl 1):A-104–5.

    Article  Google Scholar 

  19. Bernstein IL, Li JT, Bernstein DI, et al. Allergy diagnostic testing: an updated practice parameter. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1–148.

    CAS  Google Scholar 

  20. Anton Remirez J, Escudero R, Caceres O, Fernandez-Benitez M. Eosinophilic esophagitis. Allergol Immunopathol (Madr). 2006;34(2):79–81.

    Article  Google Scholar 

  21. Furuta GT, Liacouras CA, Collins MH, et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology. 2007;133(4):1342–63.

    Article  PubMed  CAS  Google Scholar 

  22. Spergel JM. Eosinophilic esophagitis in adults and children: evidence for a food allergy ­component in many patients. Curr Opin Allergy Clin Immunol. 2007;7(3):274–8.

    Article  PubMed  Google Scholar 

  23. Spergel JM, Andrews T, Brown-Whitehorn TF, Beausoleil JL, Liacouras CA. Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol. 2005;95(4):336–43.

    Article  PubMed  Google Scholar 

  24. Sugnanam KK, Collins JT, Smith PK, et al. Dichotomy of food and inhalant allergen sensitization in eosinophilic esophagitis. Allergy. 2007;62(11):1257–60.

    Article  PubMed  CAS  Google Scholar 

  25. Fogg MI, Ruchelli E, Spergel JM. Pollen and eosinophilic esophagitis. J Allergy Clin Immunol. 2003;112(4):796–7.

    Article  PubMed  Google Scholar 

  26. Almansa C, Krishna M, Buchner AM, et al. Seasonal distribution in newly diagnosed cases of eosinophilic esophagitis in adults. Am J Gastroenterol. 2009;104(4):828–33.

    Article  PubMed  Google Scholar 

  27. Onbasi K, Sin AZ, Doganavsargil B, Onder GF, Bor S, Sebik F. Eosinophil infiltration of the oesophageal mucosa in patients with pollen allergy during the season. Clin Exp Allergy. 2005;35(11):1423–31.

    Article  PubMed  CAS  Google Scholar 

  28. Spiegel A, Wolf DC, Sperber K, Gimenez C. An unusual presentation of eosinophilic esophagitis. Gastrointest Endosc. 2009;70(2):382–3. discussion 383.

    Article  PubMed  Google Scholar 

  29. Mishra A, Hogan SP, Brandt EB, Rothenberg ME. An etiological role for aeroallergens and eosinophils in experimental esophagitis. J Clin Invest. 2001;107(1):83–90.

    Article  PubMed  CAS  Google Scholar 

  30. Assa’ad A. Eosinophilic esophagitis: association with allergic disorders. Gastrointest Endosc Clin N Am. 2008;18(1):119–32. x.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Eosinophilic Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, One Brookline Place, Suite 623, Brookline, MA, 02132, USA

    Javed Sheikh MD

  2. Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Katherine N. Cahill MD (Clinical Fellow in Allergy and Immunology)

Authors
  1. Javed Sheikh MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Katherine N. Cahill MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Javed Sheikh MD .

Editor information

Editors and Affiliations

  1. The Children’s Hospital of Philadelphia, Center for Pediatric Eosinophilic Disord, The Univeristy of Pennsylvania School of, 34th Street & Civic Center Blvd., Philadelphia, 19104, Pennsylvania, USA

    Chris A. Liacouras

  2. University Medical Center, Pediatric Gastroenterology and Nutrition, Greenville Hospital System, Patewood Drive 200, Greenville, 29615, South Carolina, USA

    Jonathan E. Markowitz

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Sheikh, J., Cahill, K.N. (2012). Atopic and Allergic Features of Adults with Eosinophilic Esophagitis. In: Liacouras, C., Markowitz, J. (eds) Eosinophilic Esophagitis. Clinical Gastroenterology. Humana Press. https://doi.org/10.1007/978-1-60761-515-6_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-60761-515-6_18

  • Published:

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-514-9

  • Online ISBN: 978-1-60761-515-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation