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Eosinophilic Esophagitis pp 201–217Cite as

Complications Associated with Eosinophilic Esophagitis

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Abstract

Eosinophilic esophagitis is a chronic inflammatory disease associated with dense esophageal eosinophilia, hyperplastic epithelia and subepithelial fibrosis [1]. As clinical recognition of eosinophilic esophagitis (EoE) increases, so too do observations identifying complications of the disease and its treatments. For the purposes of this chapter, complications will be defined as unfavourable evolutions of chronic inflammation or untoward consequences of ongoing treatment. In this regard, partial or complete esophageal obstruction due to esophageal narrowings or food impaction and eating difficulties are two important complications of EoE. With respect to chronic treatment, the overall goal is to resolve symptoms and prevent EoE-related complications. But treatment endpoints have not been established and thus, the exact duration, frequency, expense and type treatments have not been formally established. Because of this lack of guidelines, clinicians are potentially faced with complications related to endoscopic procedures, medical treatments and nutritional restrictions. In this chapter, we will provide our interpretation of the literature and summary of our clinical experiences of these complications in children and adult patients with EoE.

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Acknowledgements

Glenn T. Furuta acknowledges the insightful guidance and expertise of Victor Fox, Dan Atkins, Nancy Creskoff Maune and Angela Haas in the development and writing of this chapter.

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Authors and Affiliations

  1. Department of Surgery, Northumbria Healthcare, Tyne + Wear, UK

    Stephen E. Attwood FRCS, FRCSI, MCh, BA Mod Physiol

  2. Gastrointestinal Eosinophilic Diseases Program, The Children’s Hospital Colorado, National Jewish Health, University of Colorado Denver School of Medicine, 13123 East 16th Ave. B290, Aurora, CO, 80016, USA

    Glenn T. Furuta MD

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  1. Stephen E. Attwood FRCS, FRCSI, MCh, BA Mod Physiol
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Correspondence to Glenn T. Furuta MD .

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Editors and Affiliations

  1. The Children’s Hospital of Philadelphia, Center for Pediatric Eosinophilic Disord, The Univeristy of Pennsylvania School of, 34th Street & Civic Center Blvd., Philadelphia, 19104, Pennsylvania, USA

    Chris A. Liacouras

  2. University Medical Center, Pediatric Gastroenterology and Nutrition, Greenville Hospital System, Patewood Drive 200, Greenville, 29615, South Carolina, USA

    Jonathan E. Markowitz

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Attwood, S.E., Furuta, G.T. (2012). Complications Associated with Eosinophilic Esophagitis. In: Liacouras, C., Markowitz, J. (eds) Eosinophilic Esophagitis. Clinical Gastroenterology. Humana Press. https://doi.org/10.1007/978-1-60761-515-6_15

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