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Clinical Presentation of Eosinophilic Esophagitis in Adults

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Eosinophilic Esophagitis

Part of the book series: Clinical Gastroenterology ((CG))

Abstract

Over the past decade, eosinophilic esophagitis (EoE) has emerged as one of the most common causes of dysphagia and food impaction in adults. This chronic condition is characterized by increased esophageal eosinophils in the setting of esophageal symptoms. While EoE may occur in conjunction with eosinophilic gastroenteritis, the rising field is related to the subset with isolated esophageal eosinophilia. Development of EoE in adults is likely due to a multitude of factors, including esophageal acid exposure, food and environmental allergens, and genetic predisposition. While investigation into each of these areas is actively being studied and discussed in further detail elsewhere in this book, this chapter will highlight the clinical presentation of EoE in adults.

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References

  1. Rothenberg ME. Pathogenesis and clinical features of eosinophilic esophagitis. J Allergy Clin Immunol. 2001;108(6):891–4.

    Article  PubMed  CAS  Google Scholar 

  2. Straumann A, Simon HU. Eosinophilic esophagitis: escalating epidemiology? J Allergy Clin Immunol. 2005;115(2):418–9.

    Article  PubMed  Google Scholar 

  3. Prasad GA, Alexander JA, Schleck CD, et al. Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, Minnesota. Clin Gastroenterol Hepatol. 2009;7(10):1055–61.

    Article  PubMed  Google Scholar 

  4. Veerappan GR, Perry JL, Duncan TJ, et al. Prevalence of eosinophilic esophagitis in an adult population undergoing upper endoscopy: a prospective study. Clin Gastroenterol Hepatol. 2009;7(4):420–6. 426.e1-2.

    Article  PubMed  Google Scholar 

  5. Kugathasan S, Judd RH, Hoffmann RG, et al. Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based study. J Pediatr. 2003;143(4):525–31.

    Article  PubMed  Google Scholar 

  6. Gonsalves N, Policarpio-Nicolas M, Zhang Q, et al. Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis. Gastrointest Endosc. 2006;64(3):313–9.

    Article  PubMed  Google Scholar 

  7. Furuta GT, Liacouras CA, Collins MH, et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology. 2007;133(4):1342–63.

    Article  PubMed  CAS  Google Scholar 

  8. Desai TK, Stecevic V, Chang CH, et al. Association of eosinophilic inflammation with esophageal food impaction in adults. Gastrointest Endosc. 2005;61(7):795–801.

    Article  PubMed  Google Scholar 

  9. Shim LS, Grehan M. Oesophageal perforation during endoscopy for food impaction in patients with eosinophilic oesophagitis. J Gastroenterol Hepatol. 2010;25(2):428.

    Article  PubMed  Google Scholar 

  10. Assa’ad A, Putnam PE, Collins MH, et al. Eosinophilic esophagitis: association with allergic disorders. Gastrointest Endosc Clin N Am. 2008;18(1):119–32.

    Article  PubMed  Google Scholar 

  11. Kapel RC, Miller JK, Torres C, et al. Eosinophilic esophagitis in the US: a prevalent disease that affects all age groups. Gastroenterology. 2008;134(5):1316–21.

    Article  PubMed  Google Scholar 

  12. Morrow JB, Vargo JJ, Goldblum JR, et al. The ringed esophagus: histological features of GERD. Am J Gastroenterol. 2001;96(4):984–9.

    Article  PubMed  CAS  Google Scholar 

  13. Roy-Ghanta S, Larosa DF, Katzka DA. Atopic characteristics of adults with eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2008;6(5):531–5.

    Article  PubMed  Google Scholar 

  14. Penfield JD, Lang DM, Goldblum JR, et al. The role of allergy evaluation in adults with eosinophilic esophagitis. J Clin Gastroenterol. 2010;44(1):22–7.

    Article  PubMed  Google Scholar 

  15. Almansa C, Krishna M, Buchner AM, et al. Seasonal distribution in newly diagnosed cases of eosinophilic esophagitis in adults. Am J Gastroenterol. 2009;104(4):828–33.

    Article  PubMed  Google Scholar 

  16. Gonsalves N, Yang G, Doerfler B, et al. A prospective clinical trial of six food elimination diet and reintroduction of causative agents in adults with eosinophilic esophagitis. Gastroenterology. 2008;134(4):A104.

    Article  Google Scholar 

  17. Patel SM, Falchuk KR. Three brothers with dysphagia caused by eosinophilic esophagitis. Gastrointest Endosc. 2005;61(1):165–7.

    Article  PubMed  Google Scholar 

  18. Meyer GW. Eosinophilic esophagitis in a father and a daughter. Gastrointest Endosc. 2005;61(7):932.

    Article  PubMed  Google Scholar 

  19. Zink DA, Amin M, Gebara S, et al. Familial dysphagia and eosinophilia. Gastrointest Endosc. 2007;65(2):330–4.

    Article  PubMed  Google Scholar 

  20. Liacouras CA, Spergel JM, Ruchelli E, et al. Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol. 2005;3(12):1198–206.

    Article  PubMed  Google Scholar 

  21. Blanchard C, Wang N, Stringer KF, et al. Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J Clin Invest. 2006;116(2):536–47.

    Article  PubMed  CAS  Google Scholar 

  22. Lucendo AJ, Navarro M, Comas C, et al. Treatment with topical steroids downregulates IL-5, eotaxin-1/CCL11, and eotaxin-3/CCL26 gene expression in eosinophilic esophagitis. Am J Gastroenterol. 2008;103(9):2184–93.

    Article  PubMed  CAS  Google Scholar 

  23. Bhattacharya B, Carlsten J, Sabo E, et al. Increased expression of eotaxin-3 distinguishes between eosinophilic esophagitis and gastroesophageal reflux disease. Hum Pathol. 2007;38(12): 1744–53.

    Article  PubMed  CAS  Google Scholar 

  24. Gonsalves N, Hsu-Blatman K, Hirano I et al. The role of permeability, inflammation and ­proliferation genes in adults with eosinophilic esophagitis and their alteration in response to dietary therapy. Gastroenterology. 2010;S1072.

    Google Scholar 

  25. Straumann A, Spichtin HP, Grize L, et al. Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. Gastroenterology. 2003;125(6):1660–9.

    Article  PubMed  Google Scholar 

  26. Wolfsen HC, Hemminger LL, Achem SR. Eosinophilic esophagitis and Barrett’s esophagus with dysplasia. Clin Gastroenterol Hepatol. 2007;5(12):A18.

    Article  PubMed  Google Scholar 

  27. Toto E, Kern E, Moy N et al. Duration of dysphagia is associated with increased frequency of dysphagia and food impaction in adults with eosinophilic esophagitis. Gastroenterology. 2010;S1088.

    Google Scholar 

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Correspondence to Nirmala Gonsalves MD .

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Gonsalves, N. (2012). Clinical Presentation of Eosinophilic Esophagitis in Adults. In: Liacouras, C., Markowitz, J. (eds) Eosinophilic Esophagitis. Clinical Gastroenterology. Humana Press. https://doi.org/10.1007/978-1-60761-515-6_10

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  • DOI: https://doi.org/10.1007/978-1-60761-515-6_10

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-514-9

  • Online ISBN: 978-1-60761-515-6

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