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G-Protein-Evoked Signaling Mechanisms in Asthma and Allergic Disease

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National Institute of Allergy and Infectious Diseases, NIH

Part of the book series: Infectious Disease ((ID))

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Abstract

Asthma, which is characterized by chronic and reversible airways obstruction, leads to shortness of breath, cough, wheezing, and occasionally death, due to respiratory failure [1]. Asthma is extremely common, affecting 5–8% of the U.S. population [2]. This disease accounts for substantial morbidity and mortality, and over $18 billion in direct (e.g., hospitalizations) and indirect (loss of income or productivity due to illness) health care dollars each year in the United States [3]. Despite the recognition, over the last twenty years, that asthma is often accompanied by chronic inflammation and an accordant shift in treatment strategies to include the use of anti-inflammatory agents [4], the incidence of asthma and of mortality due to asthma continue to rise [2–3].

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Author information

Authors and Affiliations

  1. Molecular Signal Transduction Section, Laboratory of Allergic Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Disease, NIH, Bethesda, MD, USA

    Kirk M. Druey

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  1. Kirk M. Druey
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Editors and Affiliations

  1. Dept. Health & Human Services, National Institute of Health, Rockledge Drive 6610, Bethesda, 20892, Maryland, USA

    Vassil St. Georgiev

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Druey, K.M. (2010). G-Protein-Evoked Signaling Mechanisms in Asthma and Allergic Disease. In: Georgiev, V. (eds) National Institute of Allergy and Infectious Diseases, NIH. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-512-5_29

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  • DOI: https://doi.org/10.1007/978-1-60761-512-5_29

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-511-8

  • Online ISBN: 978-1-60761-512-5

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