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Role of the NKG2D Receptor in Health and Disease

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National Institute of Allergy and Infectious Diseases, NIH

Part of the book series: Infectious Disease ((ID))

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Abstract

Natural-killer (NK) cells are inflammatory cytokine-producing and/or cytotoxic lymphocytes that comprise a major component of the innate immune system. NK cells express a large variety of activating receptors dedicated to accomplishing this task, one of which is NKG2D. This receptor is also expressed on subsets of T cells, where it functions to transmit co-stimulatory signals. The fact that viruses and tumors have evolved strategies to evade NKG2D-mediated immune recognition highlights the importance of this receptor in immunity. This article describes the molecular properties of NKG2D; the diverse array of ligands with which it interacts; the biological mechanisms that regulate its cell-surface expression and, very importantly, the role that NKG2D plays in a variety of disease pathologies.

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Authors and Affiliations

  1. Pfizer Global Research and Development, Sandwich, Kent, UK, CT13 9NJ

    Steven J. Burgess

  2. Receptor Cell Biology Section, Laboratory of Immunogenetics, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD, USA

    Sriram Narayanan

  3. Laboratory of Molecular and Develomental Immunology, Division of Monoclonal Antibodies, CDER/FDA, Bethesda, MD, USA

    Francisco Borrego

  4. Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Division of Intramural Research, National Institutes of Health, NIH, Rockville, MD, USA

    John E. Coligan

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  1. Steven J. Burgess
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  2. Sriram Narayanan
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  3. Francisco Borrego
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  4. John E. Coligan
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  1. Dept. Health & Human Services, National Institute of Health, Rockledge Drive 6610, Bethesda, 20892, Maryland, USA

    Vassil St. Georgiev

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Burgess, S.J., Narayanan, S., Borrego, F., Coligan, J.E. (2010). Role of the NKG2D Receptor in Health and Disease. In: Georgiev, V. (eds) National Institute of Allergy and Infectious Diseases, NIH. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-512-5_28

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