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The Evolution of Gammaretrovirus Restriction Factors in the Mouse

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National Institute of Allergy and Infectious Diseases, NIH

Part of the book series: Infectious Disease ((ID))

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Abstract

Mice exposed to infectious retroviruses are subject to virus-induced disease or virus-induced genetic mutations. While mice are protected by the innate and acquired immune systems, they have also evolved numerous constitutively expressed antiviral factors that target various stages of the retroviral life cycle, and these factors have been identified largely in studies with gammaretroviruses, specifically the mouse leukaemia viruses (MLVs). The factors responsible for this intrinsic immunity can block or interfere with different stages in the viral life cycle, namely virus entry, uncoating and reverse transcription, integration, assembly, or release. These host resistance factors can also select for the outgrowth of virus variants able to circumvent those blocks. These evolutionary pressures result in a ratchet-like pattern of sequential mutations in host and virus that, in the critical regions of the responsible genes, generate substantial polymorphism.

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  1. Laboratory of Molecular Microbiology, Division of intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA

    Christine A. Kozak

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  1. Dept. Health & Human Services, National Institute of Health, Rockledge Drive 6610, Bethesda, 20892, Maryland, USA

    Vassil St. Georgiev

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Kozak, C.A. (2010). The Evolution of Gammaretrovirus Restriction Factors in the Mouse. In: Georgiev, V. (eds) National Institute of Allergy and Infectious Diseases, NIH. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-512-5_1

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