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Membrane Receptors, Channels and Transporters in Pulmonary Circulation pp 221–235Cite as

Hypoxic Regulation of Ion Channels and Transporters in Pulmonary Vascular Smooth Muscle

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Part of the book series: Advances in Experimental Medicine and Biology ((volume 661))

Abstract Exposure to prolonged alveolar hypoxia, as occurs with many chronic lung diseases or residence at high altitude, results in the development of pulmonary hypertension, significantly worsening patient prognosis. While the structural and functional changes that occur in the pulmonary vasculature in response to chronic hypoxia have been well characterized, less is known regarding the cellular mechanisms underlying this process. The use of animals models of hypoxic pulmonary hypertension have provided important insights into the changes that occur in the pulmonary vascular smooth muscle cells and some of the mediators involved. In this chapter, the effect of chronic hypoxia on various pulmonary arterial smooth muscle cell ion channels and transporters, and the role of the transcription factor, hypoxia-inducible factor 1, in regulating these changes, will be discussed.

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Acknowledgments

This work could not have been performed without the help of my colleagues at Johns Hopkins School of Medicine: Drs. Jim Sylvester, Jian Wang, and Gregg Semenza. In addition, it is imperative to acknowledge the technical support of Eon Rios, Michele Fallon, Letitia Weigand, and Sarah Pisarcik. Due to space restrictions, it was not possible to cite all of the excellent studies that have been published with respect to the research described in this chapter; our apologies to those whose studies were not cited.

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Authors and Affiliations

  1. Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA

    Larissa A. Shimoda

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  1. Larissa A. Shimoda
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Editors and Affiliations

  1. Departments of Medicine and Pharmacology, University of Illinois at Chicago, Chicago, 60612, USA

    Jason X. -J. Yuan

  2. Guy’s Hospital Campus, Dept. Physiology, King’s College London, London, SE1 1UL, United Kingdom

    Jeremy P. T. Ward

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Shimoda, L.A. (2010). Hypoxic Regulation of Ion Channels and Transporters in Pulmonary Vascular Smooth Muscle. In: Yuan, JJ., Ward, J. (eds) Membrane Receptors, Channels and Transporters in Pulmonary Circulation. Advances in Experimental Medicine and Biology, vol 661. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-500-2_14

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