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Suppressing the Mind pp 81–97Cite as

Anesthetic Modulation of Auditory Perception: Linking Cellular, Circuit, and Behavioral Effects

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Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

The cortical effects of general anesthetics are well characterized at the molecular, synaptic, cellular, and network levels, and several prominent endpoints of anesthetic agents are likely mediated by actions in cerebral cortex, including amnesia and loss of consciousness. However, the links between these different levels of effects and the behavioral endpoints to which they likely contribute are not well understood. Here, we present work from our lab and others’ on the effects of the general anesthetic isoflurane on auditory cortex and sensory processing. Our goal is to create an experimental and theoretical framework for understanding how the effects of isoflurane on synaptic physiology, network firing activity, and sensory processing may be related and may yield insights into the normal functioning of the brain.

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References

  • Alain, C. 2007. Breaking the wave: effects of attention and learning on concurrent sound perception. Hear Res 229(1–2):225–236.

    Article  PubMed  Google Scholar 

  • Alain, C., and A. Izenberg. 2003. Effects of attentional load on auditory scene analysis. J Cogn Neurosci 15(7):1063–1073.

    Article  PubMed  Google Scholar 

  • Alkire, M. T., A. G. Hudetz, and G. Tononi. 2008. Consciousness and anesthesia. Science 322(5903):876–880.

    Article  CAS  PubMed  Google Scholar 

  • Antkowiak, B. 2001. How do general anaesthetics work? Naturwissenschaften 88(5):201–213.

    Article  CAS  PubMed  Google Scholar 

  • Antkowiak, B., and H. Hentschke. 1997. Cellular mechanisms of gamma rhythms in rat neocortical brain slices probed by the volatile anaesthetic isoflurane. Neurosci Lett 231(2):87–90.

    Article  CAS  PubMed  Google Scholar 

  • Banks, M. I., and R. A. Pearce. 1999. Dual actions of volatile anesthetics on GABA(A) IPSCs: dissociation of blocking and prolonging effects. Anesthesiology 90(1):120–134.

    Article  CAS  PubMed  Google Scholar 

  • Beierlein, M., J. R. Gibson, and B. W. Connors. 2000. A network of electrically coupled interneurons drives synchronized inhibition in neocortex. Nat Neurosci 3(9):904–910.

    Article  CAS  PubMed  Google Scholar 

  • Belelli, D., J. J. Lambert, J. A. Peters, K. Wafford, and P. J. Whiting. 1997. The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid. Proc Natl Acad Sci USA 94(20):11031–11036.

    Article  CAS  PubMed  Google Scholar 

  • Bergles, D. E., V. A. Doze, D. V. Madison, and S. J. Smith. 1996. Excitatory actions of norepinephrine on multiple classes of hippocampal CA1 interneurons. J Neurosci 16(2):572–585.

    CAS  PubMed  Google Scholar 

  • Budd, J. M. 1998. Extrastriate feedback to primary visual cortex in primates: a quantitative analysis of connectivity. Proc Biol Sci 265(1400):1037–1044.

    Article  CAS  PubMed  Google Scholar 

  • Burlingame, R. H., S. Shrestha, M. R. Rummel, and M. I. Banks. 2007. Subhypnotic doses of isoflurane impair auditory discrimination in rats. Anesthesiology 106(4):754–762.

    Article  CAS  PubMed  Google Scholar 

  • Buzsaki, G. 2006. Rhythms of the brain. Oxford: Oxford University Press.

    Book  Google Scholar 

  • Caraiscos, V. B., E. M. Elliott, K. E. You-Ten, V. Y. Cheng, D. Belelli, J. G. Newell, M. F. Jackson, J. J. Lambert, T. W. Rosahl, K. A. Wafford, J. F. MacDonald, and B. A. Orser. 2004. Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci USA 101(10):3662–3667.

    Article  CAS  PubMed  Google Scholar 

  • Cauller, L. 1995. Layer I of primary sensory neocortex: where top-down converges upon bottom-up. Behav Brain Res 71(1–2):163–170.

    Article  CAS  PubMed  Google Scholar 

  • Cauller, L. J., and A. T. Kulics. 1991. The neural basis of the behaviorally relevant N1 component of the somatosensory-evoked potential in SI cortex of awake monkeys: evidence that backward cortical projections signal conscious touch sensation. Exp Brain Res 84(3):607–619.

    Article  CAS  PubMed  Google Scholar 

  • Davis, M. H., and I. S. Johnsrude. 2007. Hearing speech sounds: top-down influences on the interface between audition and speech perception. Hear Res 229(1–2):132–147.

    Article  PubMed  Google Scholar 

  • Detsch, O., E. Kochs, M. Siemers, B. Bromm, and C. Vahle-Hinz. 2002. Increased responsiveness of cortical neurons in contrast to thalamic neurons during isoflurane-induced EEG bursts in rats. Neurosci Lett 317(1):9–12.

    Article  CAS  PubMed  Google Scholar 

  • Di Garbo, A., M. Barbi, and S. Chillemi. 2002. Synchronization in a network of fast-spiking interneurons. Biosystems 67(1–3):45–53.

    Article  PubMed  Google Scholar 

  • Dickinson, R., S. Awaiz, M. A. Whittington, W. R. Lieb, and N. P. Franks. 2003. The effects of general anaesthetics on carbachol-evoked gamma oscillations in the rat hippocampus in vitro. Neuropharmacology 44(7):864–872.

    Article  CAS  PubMed  Google Scholar 

  • Drummond, J. C. 2000. Monitoring depth of anesthesia: with emphasis on the application of the bispectral index and the middle latency auditory evoked response to the prevention of recall. Anesthesiology 93(3):876–882.

    Article  CAS  PubMed  Google Scholar 

  • Dueck, M. H., F. Petzke, H. J. Gerbershagen, M. Paul, V. Hesselmann, R. Girnus, B. Krug, B. Sorger, R. Goebel, R. Lehrke, V. Sturm, and U. Boerner. 2005. Propofol attenuates responses of the auditory cortex to acoustic stimulation in a dose-dependent manner: a FMRI study. Acta Anaesthesiol Scand 49(6):784–791.

    Article  CAS  PubMed  Google Scholar 

  • Engel, A. K., P. Fries, and W. Singer. 2001. Dynamic predictions: oscillations and synchrony in top-down processing. Nat Rev Neurosci 2(10):704–716.

    Article  CAS  PubMed  Google Scholar 

  • Faulkner, H. J., R. D. Traub, and M. A. Whittington. 1998. Disruption of synchronous gamma oscillations in the rat hippocampal slice: a common mechanism of anaesthetic drug action. Br J Pharmacol 125(3):483–492.

    Article  CAS  PubMed  Google Scholar 

  • Felleman, D. J., and D. C. Van Essen. 1991. Distributed hierarchical processing in the primate cerebral cortex. Cereb Cortex 1(1):1–47.

    Article  CAS  PubMed  Google Scholar 

  • Fisahn, A., F. G. Pike, E. H. Buhl, and O. Paulsen. 1998. Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro. Nature 394(6689):186189.

    Article  Google Scholar 

  • Franks, N. P. 2008. General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal. Nat Rev Neurosci 9(5):370–386.

    Article  CAS  PubMed  Google Scholar 

  • Franks, N. P., and W. R. Lieb. 1994. Molecular and cellular mechanisms of general anaesthesia. Nature 367(6464):607–614.

    Article  CAS  PubMed  Google Scholar 

  • Fritz, J. B., M. Elhilali, S. V. David, and S. A. Shamma. 2007. Auditory attention–focusing the searchlight on sound. Curr Opin Neurobiol 17(4):437–455.

    Article  CAS  PubMed  Google Scholar 

  • Fritz, J. B., M. Elhilali, and S. A. Shamma. 2007. Adaptive changes in cortical receptive fields induced by attention to complex sounds. J Neurophysiol 98(4):2337–2346.

    Article  PubMed  Google Scholar 

  • Grasshoff, C., U. Rudolph, and B. Antkowiak. 2005. Molecular and systemic mechanisms of general anaesthesia: the ‘multi-site and multiple mechanisms’ concept. Curr Opin Anaesthesiol 18(4):386–391.

    Article  PubMed  Google Scholar 

  • Haist, F., A. W. Song, K. Wild, T. L. Faber, C. A. Popp, and R. D. Morris. 2001. Linking sight and sound: fMRI evidence of primary auditory cortex activation during visual word recognition. Brain Lang 76(3):340–350.

    Article  CAS  PubMed  Google Scholar 

  • Hameroff, S. R. 2006. The entwined mysteries of anesthesia and consciousness: is there a common underlying mechanism? Anesthesiology 105(2):400–412.

    Article  PubMed  Google Scholar 

  • Hecht, D., M. Reiner, and A. Karni. 2008. Enhancement of response times to bi- and tri-modal sensory stimuli during active movements. Exp Brain Res 185(4):655–665.

    Article  PubMed  Google Scholar 

  • Heinke, W., and C. Schwarzbauer. 2001. Subanesthetic isoflurane affects task-induced brain activation in a highly specific manner: a functional magnetic resonance imaging study. Anesthesiology 94(6):973–981.

    Article  CAS  PubMed  Google Scholar 

  • Hemmings, H. C. 2009. Molecular targets of general anesthetics in the nervous system. In Suppressing the mind: anesthetic modulation of memory and consciousness, edited by A. G. Hudetz and R. A. Pearce. New York City: Springer.

    Google Scholar 

  • Hudetz, A. G., and O. A. Imas. 2007. Burst activation of the cerebral cortex by flash stimuli during isoflurane anesthesia in rats. Anesthesiology 107(6):983–991.

    Article  CAS  PubMed  Google Scholar 

  • Imas, O. A., K. M. Ropella, B. D. Ward, J. D. Wood, and A. G. Hudetz. 2005. Volatile anesthetics enhance flash-induced gamma oscillations in rat visual cortex. Anesthesiology 102(5):937–947.

    Article  CAS  PubMed  Google Scholar 

  • Imas, O. A., K. M. Ropella, J. D. Wood, and A. G. Hudetz. 2006. Isoflurane disrupts anterio-posterior phase synchronization of flash-induced field potentials in the rat. Neurosci Lett 402(3):216–221.

    Article  CAS  PubMed  Google Scholar 

  • Jenkins, A., E. P. Greenblatt, H. J. Faulkner, E. Bertaccini, A. Light, A. Lin, A. Andreasen, A. Viner, J. R. Trudell, and N. L. Harrison. 2001. Evidence for a common binding cavity for three general anesthetics within the GABAA receptor. J Neurosci 21(6):RC136.

    CAS  PubMed  Google Scholar 

  • John, E. R., and L. S. Prichep. 2005. The anesthetic cascade: a theory of how anesthesia suppresses consciousness. Anesthesiology 102(2):447–471.

    Article  PubMed  Google Scholar 

  • John, E. R., L. S. Prichep, W. Kox, P. Valdes-Sosa, J. Bosch-Bayard, E. Aubert, M. Tom, F. di Michele, and L. D. Gugino. 2001. Invariant reversible QEEG effects of anesthetics. Conscious Cogn 10(2):165–183.

    Article  CAS  PubMed  Google Scholar 

  • Jones, M. V., and N. L. Harrison. 1993. Effects of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons. J Neurophysiol 70(4):1339–1349.

    CAS  PubMed  Google Scholar 

  • Kerssens, C., S. Hamann, S. Peltier, X. P. Hu, M. G. Byas-Smith, and P. S. Sebel. 2005. Attenuated brain response to auditory word stimulation with sevoflurane: a functional magnetic resonance imaging study in humans. Anesthesiology 103(1):11–19.

    Article  CAS  PubMed  Google Scholar 

  • Kisley, M. A., and G. L. Gerstein. 1999. Trial-to-trial variability and state-dependent modulation of auditory-evoked responses in cortex. J Neurosci 19(23):10451–10460.

    CAS  PubMed  Google Scholar 

  • Krupa, D. J., M. C. Wiest, M. G. Shuler, M. Laubach, and M. A. Nicolelis. 2004. Layer-specific somatosensory cortical activation during active tactile discrimination. Science 304(5679):1989–1992.

    Article  CAS  PubMed  Google Scholar 

  • Lamme, V. A., K. Zipser, and H. Spekreijse. 1998. Figure-ground activity in primary visual cortex is suppressed by anesthesia. Proc Natl Acad Sci USA 95(6):3263–3268.

    Article  CAS  PubMed  Google Scholar 

  • Lewis, T. J., and J. Rinzel. 2003. Dynamics of spiking neurons connected by both inhibitory and electrical coupling. J Comput Neurosci 14(3):283–309.

    Article  PubMed  Google Scholar 

  • Lukatch, H. S., and M. B. MacIver. 1996. Synaptic mechanisms of thiopental-induced alterations in synchronized cortical activity. Anesthesiology 84(6):1425–1434.

    Article  CAS  PubMed  Google Scholar 

  • MacIver, M. B., J. W. Mandema, D. R. Stanski, and B. H. Bland. 1996. Thiopental uncouples hippocampal and cortical synchronized electroencephalographic activity. Anesthesiology 84(6):1411–1424.

    Article  CAS  PubMed  Google Scholar 

  • MacIver, M. B., A. A. Mikulec, S. M. Amagasu, and F. A. Monroe. 1996. Volatile anesthetics depress glutamate transmission via presynaptic actions. Anesthesiology 85(4):823–834.

    Article  Google Scholar 

  • Madler, C., I. Keller, D. Schwender, and E. Poppel. 1991. Sensory information processing during general anaesthesia: effect of isoflurane on auditory evoked neuronal oscillations. Br J Anaesth 66(1):81–87.

    Article  CAS  PubMed  Google Scholar 

  • Makinen, S., K. Hartikainen, J. T. Eriksson, and V. Jantti. 1996. Spontaneous and evoked cortical dynamics during deep anaesthesia. Int J Neural Syst 7(4):481–487.

    Article  CAS  PubMed  Google Scholar 

  • Mashour, G. A. 2006. Integrating the science of consciousness and anesthesia. Anesth Analg 103(4):975–982.

    Article  PubMed  Google Scholar 

  • Massimini, M., F. Ferrarelli, R. Huber, S. K. Esser, H. Singh, and G. Tononi. 2005. Breakdown of cortical effective connectivity during sleep. Science 309 (5744):2228–2232.

    Article  CAS  PubMed  Google Scholar 

  • Merriam, E. B., T. I. Netoff, and M. I. Banks. 2005. Bistable network behavior of layer I interneurons in auditory cortex. J Neurosci 25(26):61756186.

    Article  Google Scholar 

  • Mignard, M., and J. G. Malpeli. 1991. Paths of information flow through visual cortex. Science 251(4998):1249–1251.

    Article  CAS  PubMed  Google Scholar 

  • Mihic, S. J., Q. Ye, M. J. Wick, V. V. Koltchine, M. D. Krasowski, S. E. Finn, M. P. Mascia, C. F. Valenzuela, K. K. Hanson, E. P. Greenblatt, R. A. Harris, and N. L. Harrison. 1997. Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature 389(6649):385389.

    Google Scholar 

  • Mitani, A., M. Shimokouchi, K. Itoh, S. Nomura, M. Kudo, and N. Mizuno. 1985. Morphology and laminar organization of electrophysiologically identified neurons in the primary auditory cortex in the cat. J Comp Neurol 235(4):430–447.

    Article  CAS  PubMed  Google Scholar 

  • Otis, T. S., and I. Mody. 1992. Modulation of decay kinetics and frequency of GABAA receptor-mediated spontaneous inhibitory postsynaptic currents in hippocampal neurons. Neuroscience 49(1):13–32.

    Article  CAS  PubMed  Google Scholar 

  • Pack, C. C., V. K. Berezovskii, and R. T. Born. 2001. Dynamic properties of neurons in cortical area MT in alert and anaesthetized macaque monkeys. Nature 414(6866):905–908.

    Article  CAS  PubMed  Google Scholar 

  • Perouansky, M., D. Baranov, M. Salman, and Y. Yaari. 1995. Effects of halothane on glutamate receptor-mediated excitatory postsynaptic currents. A patch-clamp study in adult mouse hippocampal slices. Anesthesiology 83(1):109–119.

    Article  CAS  PubMed  Google Scholar 

  • Peters, J. H., S. J. McDougall, D. Mendelowitz, D. R. Koop, and M. C. Andresen. 2008. Isoflurane differentially modulates inhibitory and excitatory synaptic transmission to the solitary tract nucleus. Anesthesiology 108(4):675–683.

    Article  CAS  PubMed  Google Scholar 

  • Plourde, G., P. Belin, D. Chartrand, P. Fiset, S. B. Backman, G. Xie, and R. J. Zatorre. 2006. Cortical processing of complex auditory stimuli during alterations of consciousness with the general anesthetic propofol. Anesthesiology 104(3):448–457.

    Article  PubMed  Google Scholar 

  • Pockett, S. 1999. Anesthesia and the electrophysiology of auditory consciousness. Conscious Cogn 8(1):45–61.

    Article  CAS  PubMed  Google Scholar 

  • Rabe, L. S., L. Moreno, B. M. Rigor, and N. Dafny. 1980. Effects of halothane on evoked field potentials recorded from cortical and subcortical nuclei. Neuropharmacology 19(9):813–825.

    Article  CAS  PubMed  Google Scholar 

  • Rockland, K. S., and A. Virga. 1989. Terminal arbors of individual “feedback” axons projecting from area V2 to V1 in the macaque monkey: a study using immunohistochemistry of anterogradely transported Phaseolus vulgaris-leucoagglutinin. J Comp Neurol 285(1):54–72.

    Article  CAS  PubMed  Google Scholar 

  • Rudolph, U., and B. Antkowiak. 2004. Molecular and neuronal substrates for general anaesthetics. Nat Rev Neurosci 5(9):709–720.

    Article  CAS  PubMed  Google Scholar 

  • Rummel, M. R., Banks, M. I. 2007. Within-trial correlations across time and frequency in cortical evoked potentials are altered abruptly at anesthetic doses causing loss of consciousness. Soc Neurosci Abstr 33:505.2.

    Google Scholar 

  • Salin, P. A., H. Kennedy, and J. Bullier. 1995. Spatial reciprocity of connections between areas 17 and 18 in the cat. Can J Physiol Pharmacol 73(9):1339–1347.

    CAS  PubMed  Google Scholar 

  • Sandell, J. H., and P. H. Schiller. 1982. Effect of cooling area 18 on striate cortex cells in the squirrel monkey. J Neurophysiol 48(1):38–48.

    CAS  PubMed  Google Scholar 

  • Santarelli, R., E. Arslan, L. Carraro, G. Conti, M. Capello, and G. Plourde. 2003. Effects of isoflurane on the auditory brainstem responses and middle latency responses of rats. Acta Otolaryngol 123(2):176–181.

    Article  CAS  PubMed  Google Scholar 

  • Scheller, B., G. Schneider, M. Daunderer, E. F. Kochs, and B. Zwissler. 2005. High-frequency components of auditory evoked potentials are detected in responsive but not in unconscious patients. Anesthesiology 103(5):944–950.

    Article  PubMed  Google Scholar 

  • Schlame, M., and H. C. Hemmings, Jr. 1995. Inhibition by volatile anesthetics of endogenous glutamate release from synaptosomes by a presynaptic mechanism. Anesthesiology 82(6):1406–1016.

    Article  CAS  PubMed  Google Scholar 

  • Schwender, D., S. Klasing, C. Madler, E. Poppel, and K. Peter. 1993. Depth of anesthesia. Midlatency auditory evoked potentials and cognitive function during general anesthesia. Int Anesthesiol Clin 31(4):89–106.

    Article  CAS  PubMed  Google Scholar 

  • Sharp, A. A., M. B. O'Neil, L. F. Abbott, and E. Marder. 1993. The dynamic clamp: artificial conductances in biological neurons. Trends Neurosci 16(10):389–394.

    Article  CAS  PubMed  Google Scholar 

  • Steriade, M., D. A. McCormick, and T. J. Sejnowski. 1993. Thalamocortical oscillations in the sleeping and aroused brain. Science 262(5134):679–685.

    Article  CAS  PubMed  Google Scholar 

  • Tanelian, D. L., P. Kosek, I. Mody, and M. B. MacIver. 1993. The role of the GABAA receptor/chloride channel complex in anesthesia. Anesthesiology 78(4):757–776.

    Article  CAS  PubMed  Google Scholar 

  • Taylor, S. R., O. A. Khan, M. L. Swart, G. G. Lockwood, and J. G. Jones. 1998. Effects of a low concentration of isoflurane on contrast sensitivity in volunteers. Br J Anaesth 81(2):176–179.

    CAS  PubMed  Google Scholar 

  • Van Vreeswijk, C., L. F. Abbott, and G. B. Ermentrout. 1994. When inhibition not excitation synchronizes neural firing. J Comput Neurosci 1(4):313–321.

    Article  PubMed  Google Scholar 

  • Verbny, Y. I., E. B. Merriam, and M. I. Banks. 2005. Modulation of gamma-aminobutyric acid type A receptor-mediated spontaneous inhibitory postsynaptic currents in auditory cortex by midazolam and isoflurane. Anesthesiology 102(5):962–969.

    Article  CAS  PubMed  Google Scholar 

  • Wang, X. 2007. Neural coding strategies in auditory cortex. Hear Res 229(1–2):81–93.

    Article  PubMed  Google Scholar 

  • Wang, X. J., and G. Buzsaki. 1996. Gamma oscillation by synaptic inhibition in a hippocampal interneuronal network model. J Neurosci 16(20):6402–6413.

    CAS  PubMed  Google Scholar 

  • Warren, R. M. 1970. Perceptual restoration of missing speech sounds. Science 167(917):392–393.

    Article  CAS  PubMed  Google Scholar 

  • White, J. A., C. C. Chow, J. Ritt, C. Soto-Trevino, and N. Kopell. 1998. Synchronization and oscillatory dynamics in heterogeneous, mutually inhibited neurons. J Comput Neurosci 5(1):5–16.

    Article  CAS  PubMed  Google Scholar 

  • Whittington, M. A., R. D. Traub, and J. G. Jefferys. 1995. Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation. Nature 373(6515):612–615.

    Article  CAS  PubMed  Google Scholar 

  • Whittington, M. A., J. G. Jefferys, and R. D. Traub. 1996. Effects of intravenous anaesthetic agents on fast inhibitory oscillations in the rat hippocampus in vitro. Br J Pharmacol 118(8):1977–1986.

    CAS  PubMed  Google Scholar 

  • Yeung, J. Y., K. J. Canning, G. Zhu, P. Pennefather, J. F. MacDonald, and B. A. Orser. 2003. Tonically activated GABAA receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA. Mol Pharmacol 63(1):2–8.

    Article  CAS  PubMed  Google Scholar 

  • Zeki, S., and S. Shipp. 1988. The functional logic of cortical connections. Nature 335(6188):311–317.

    Article  CAS  PubMed  Google Scholar 

  • Zhu, Y., and J. J. Zhu. 2004. Rapid arrival and integration of ascending sensory information in layer 1 nonpyramidal neurons and tuft dendrites of layer 5 pyramidal neurons of the neocortex. J Neurosci 24(6):1272–1279.

    Article  CAS  PubMed  Google Scholar 

  • Zimmerman, S. A., M. V. Jones, and N. L. Harrison. 1994. Potentiation of gamma-aminobutyric acidA receptor Cl- current correlates with in vivo anesthetic potency. J Pharmacol Exp Ther 270(3):987–991.

    CAS  PubMed  Google Scholar 

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Acknowledgements

Supported by National Institutes of Health (Bethesda, MD, USA) DC006013 (to M. I. Banks) and the Department of Anesthesiology, University of Wisconsin, Madison, WI, USA.

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  1. Department of Anesthesiology, University of Wisconsin, 53706, Madison, WI, USA

    Matthew I. Banks

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  1. Matthew I. Banks
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  1. Dept. Anesthesiology, Medical College of Wisconsin, Watertown Plank Road 8701, Milwaukee, 53226, U.S.A.

    Anthony Hudetz

  2. Dept. Anesthesiology, University of Wisconsin-Madison, University Ave. 1300, Madison, 53706, U.S.A.

    Robert Pearce

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Banks, M.I. (2009). Anesthetic Modulation of Auditory Perception: Linking Cellular, Circuit, and Behavioral Effects. In: Hudetz, A., Pearce, R. (eds) Suppressing the Mind. Contemporary Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-60761-462-3_4

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