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Cancer and IgE pp 13–36Cite as

The Biology of IgE: Molecular Mechanism Restraining Potentially Dangerous High Serum IgE Titres In Vivo

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Abstract

Our knowledge about the regulation of the expression of IgE and its biological function is at best limited. We do, however, know that the production of IgE is tightly regulated which is reflected by the fact that the steady-state serum levels of IgE in mice and humans are 3–4 orders of magnitude lower if compared to IgG1, which is an immunoglobulin isotype expressed in response to the same cytokine milieu. What are the rate-limiting steps responsible for this discrepancy? In the following chapter six molecular mechanisms restraining IgE levels will be discussed in detail. The understanding of these mechanisms, combined with the analysis of the biological function of the IgE molecule during an immune response, is the prerequisite for the establishment of new systemic IgE-targeted therapeutic strategies in the future.

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Acknowledgements

Experimental work and publication charges were supported by the Austrian Science Foundation (P19017-B13), the Austrian National Bank (OENB grant: 11710) and the Christian Doppler Laboratory for Allergy Diagnosis and Therapy.

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Authors and Affiliations

  1. Department of Molecular Biology, University of Salzburg, Salzburg, Austria

    Gernot Achatz, Gertrude Achatz-Straussberger, Stefan Feichtner, Sebastian Koenigsberger, Stefan Lenz, Doris Peckl-Schmid & Nadja Zaborsky

  2. Max Planck Institute for Immunobiology, Freiburg, Germany

    Marinus Lamers

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  1. Gernot Achatz
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Correspondence to Gernot Achatz .

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  1. David Geffen School of Medicine, University of California, Los Angeles, Le Conte Ave. 10833, Los Angeles, 90095, U.S.A.

    Manuel L. Penichet

  2. Zentrum für Physiologie,, Medizinische Universität Wien, Währinger Gürtel 18-20, Wien, 1090, Austria

    Erika Jensen-Jarolim

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Achatz, G. et al. (2010). The Biology of IgE: Molecular Mechanism Restraining Potentially Dangerous High Serum IgE Titres In Vivo. In: Penichet, M., Jensen-Jarolim, E. (eds) Cancer and IgE. Humana Press. https://doi.org/10.1007/978-1-60761-451-7_2

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