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Excessive Daytime Sleepiness in Parkinson’s Disease

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Parkinson’s Disease and Nonmotor Dysfunction

Part of the book series: Current Clinical Neurology ((CCNEU))

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Abstract

Much has been written about sleep issues associated with Parkinson’s disease (PD), including excessive daytime sleepiness (EDS). This chapter enumerates these issues related to the disease itself, whether directly or indirectly. Secondary causes of EDS, as well as recognition and management of EDS, will be addressed. We also examine some of the possible mechanisms involved and highlight some unique aspects

The term, EDS, refers to the inappropriate propensity for, as well as the actual inappropriate occurrence of, sleep during normal waking hours. EDS is a real and serious component of PD. Since the recognition of EDS years ago there have been a plethora of articles, research, and observations on sleep in patients with PD and sleep issues have been incorporated into the rubric of what constitutes PD. In the last decade, new scales have been developed (e.g., the SCOPA scale, the Pittsburgh Sleepiness Quality Index, and the Parkinson’s Disease Sleep Scales 1 and 2). More telling perhaps, the revised Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) includes questions regarding nocturnal and daytime sleep.

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References

  1. Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P, Poewe W, Sampaio C, Stern MB, Dodel R, Dubois B, Holloway R, Jankovic J, Kulisevsky J, Lang AE, Lees A, Leurgans S, LeWitt PA, Nyenhuis D, Olanow CW, Rascol O, Schrag A, Teresi JA, van Hilten JJ, LaPelle N, Movement Disorder Society UPDRS Revision Task Force. Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord. 2008;23(15):2129–70.

    Article  PubMed  Google Scholar 

  2. Tandberg E, Larsen JP, Karlsen K. A community-based study of sleep disorders in patients with Parkinson’s disease. Mov Disord. 1998;13(6):895–9.

    Article  PubMed  CAS  Google Scholar 

  3. Menza M, Dobkin RD, Marin H, Bienfait K. Sleep disturbances in Parkinson’s disease. Mov Disord. 2010;25:S117–22.

    Article  PubMed  Google Scholar 

  4. Singh R, Pentland B, Hunter J, Provan F. Parkinson’s disease and driving ability. J Neurol Neurosurg Psychiatry. 2007;78:363–6.

    Article  PubMed  Google Scholar 

  5. Uc EY, Rizzo M, Johnson AM, Emerson JL, Liu D, Mills ED, Anderson SW, Dawson JD. Real life driving outcomes in Parkinson’s disease. Neurology. 2011;76(22):1894–902.

    Article  PubMed  CAS  Google Scholar 

  6. Petit D, Gagnon JF, Fantini ML, Ferini-Strambi L, Montplaisir J. Sleep and quantitative EEG in neurodegenerative disorders. J Psychosom Res. 2004;56(5):487–96.

    Article  PubMed  Google Scholar 

  7. Diederich NJ, Valliant M, Leischen M, Mancuso G, Golinval S, et al. Sleep apnea syndrome in Parkinson’s disease. Mov Disord. 2005;20:1413–8.

    Article  PubMed  Google Scholar 

  8. Yong M, Fook-Chong S, Pavanni R, Lim LL, Tan EK. Case control polysomnography studies of sleep disorders in Parkinson’s disease. PLoS One. 2011;6(7): e22511.1–7.

    Article  CAS  Google Scholar 

  9. Stavitsky K, McNamara P, Durso R, Harris E, Auerbach S, Cronin Golomb A. Hallucination, dreaming and frequent dozing in Parkinson’s disease: impact of right hemisphere neural networks. Cogn Behav Neurol. 2008;21(3):143–9.

    Article  PubMed  Google Scholar 

  10. Kato S, Watanabe H, Senda J, Hirayama M, Ito M, Atsuta N, Kaga T, Katsuno M, Naganawa S, Sobue G. Widespread cortical and subcortical brain atrophy in Parkinson’s disease with excessive daytime sleepiness. J Neurol. 2012;259(2):318–26.

    Article  PubMed  CAS  Google Scholar 

  11. Stockner H, Iranzo A, Seppi K, Serradell M, Gschliesser V, Sojer M, Valldeoriola F, Molinuevo JL, Frauscher B, Santamaria J, Hogl B, Tolosa E, Poewe W, SINBAR (Sleep Innsbruck Barcelona) Group. Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder. Mov Disord. 2009;24(13):1906–9.

    Article  PubMed  Google Scholar 

  12. Iranzo A, Valldeoriola F, Lomena F, Molinuevo JL, Serradell M, Slamero M, Cot A, Ros D, Pavia J, Santamaria J, Tolosa E. Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid eye movement sleep behavior disorder: a prospective study. Lancet Neurol. 2011;10(9):797–805.

    Article  PubMed  CAS  Google Scholar 

  13. Saper CB, Lu J, Chou TC, Gooley J. The hypothalamic integrator for circadian rhythms. Trends Neurosci. 2005;28:152–7.

    Article  PubMed  CAS  Google Scholar 

  14. Braak H, Rub U, Gai WP, Del Tredici K. Idiopathic Parkinson’s disease: possible routes by which vulnerable types may be subject to neuroinvasion by an unknown pathogen. J Neural Trans. 2003;110: 517–36.

    Article  CAS  Google Scholar 

  15. Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging. 2003;24(2):197–211.

    Article  PubMed  Google Scholar 

  16. Braak H, Bohl JR, Muller CM, Rub U, De Vos RA, Tredici K. Stanley Fahn Lecture 2005: the staging procedure for the inclusion body pathology associated with sporadic Parkinson’s disease reconsidered. Mov Disord. 2006;21(12):2042–51.

    Article  PubMed  Google Scholar 

  17. Borbely AA. A two process model of sleep regulation. Hum Neurobiol. 1982;1:195–204.

    PubMed  CAS  Google Scholar 

  18. Cai Y, Liu S, Sothern RB, Xu S, Chan P. Expression of clock genes Per1, and Bam1 in total leukocytes in health and Parkinson’s disease. Eur J Neurol. 2010;17:550–4.

    Article  PubMed  CAS  Google Scholar 

  19. Hilker R, Razai N, Ghaemi M, Weisenbach S, Rudolf J, Szelies B, Heiss WD. [18F] fluorodopa uptake in the upper brainstem measured with positron emission tomography correlates with decreased REM sleep duration in early Parkinson’s disease. Clin Neurol Neurosurg. 2003;10(4):262–9.

    Article  Google Scholar 

  20. Srinivasan V, Cardinali D, Srinivsan US, Kaur C, Brown GM, Spence WD, Hardeland R, Pandi-Perumal SR. Therapeutic potential of melatonin and its analogs in Parkinson’s disease; focus on sleep and neuroprotection. Ther Adv Neurol Disord. 2011;4(5): 297–317.

    Article  PubMed  CAS  Google Scholar 

  21. Adi N, Mash D, Ali Y, Singer C, Shehadeh L, Papapetropoulos S. Melatonin MT1 and MT2 receptor expression in Parkinson’s disease. Med Sci Monit. 2010;16:BR61–7.

    PubMed  CAS  Google Scholar 

  22. Bordet R, Devos D, Brique S, Touitou Y, Guieu JD, Libersa C, et al. Study of circadian melatonin secretion pattern at different stages of Parkinson’s disease. Clin Neuropharmacol. 2003;26:65–72.

    Article  PubMed  CAS  Google Scholar 

  23. Fertl E, Auff E, Doppelbauer A, Waldhauser F. Circadian secretion pattern of melatonin in Parkinson’s disease. J Neural Transm Park Dis Dement Sect. 1991;3:41–7.

    Article  PubMed  CAS  Google Scholar 

  24. Fertl E, Auff E, Dopplebauer A, Waldhauser F. Circadian secretion pattern of melatonin in de novo parkinsonian patients: evidence for phase shifting properties of l-dopa. J Neural Transm Park Dis Dement Sect. 1993;5:227–34.

    Article  PubMed  CAS  Google Scholar 

  25. Mena-Segovia J, Cintra L, Prospero-Garcia O, Giordano M. Changes in sleep-waking cycle after striatal excitotoxic lesions. Behav Brain Res. 2002;136:475–81.

    Article  PubMed  Google Scholar 

  26. Antolin I, Mayo JC, Sainz RM, del Brio ML, Herrera F, Martin V, et al. Protective effect of melatonin in a chronic experimental model of Parkinson’s disease. Brain Res. 2002;943:163–73.

    Article  PubMed  CAS  Google Scholar 

  27. Hardeland R, Cardinali DP, Srinivasan V, Spence DW, Brown GM, Pandi-Perumal SR. Melatonin – a pleotropic, orchestrating regulator molecule. Progr Neurobiol. 2011;93:350–84.

    Article  CAS  Google Scholar 

  28. Dowling GA, Mastick J, Colling E, Carter JH, Singer CM, Aminoff MJ. Melatonin for sleep disorders in Parkinson’s disease. Sleep Med. 2005;6:459–66.

    Article  PubMed  Google Scholar 

  29. Mederios CA, Carvalhedo de Bruin PF, Lopes LA, Magalhaes MC, de Lourdes Seabra M, de Bruin VM. Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson’s disease. A randomized, double blind, placebo-controlled study. J Neurol. 2007;25(4):459–64.

    Article  CAS  Google Scholar 

  30. Boeve BF, Silber MH, Ferman TJ. Melatonin for treatment of REM sleep behavior disorder in neurologic disorders; results in 14 patients. Sleep Med. 2003;4:281–4.

    Article  PubMed  Google Scholar 

  31. Decker M, et al. Parkinsonian like sleep-wake architecture in rats with bilateral striatal 6-OHDA lesion. Soc Neurosci Abstr. 2000;26:1514. Abstract.

    Google Scholar 

  32. Daley J, Turner RS, Bliwise DL, Rye DB. Nocturnal sleep and daytime alertness in the MPTP-treated primate. Sleep. 1999;22(Suppl):S218–9.

    Google Scholar 

  33. Rye DB, Jankovic J. Emerging views of dopamine in modulating sleep/wake state from an unlikely source: PD. Neurology. 2002;58:341–6.

    Article  PubMed  Google Scholar 

  34. van Hilten B, Hoff JI, Middlekoop HA, van der Velde EA, Kerkhof GA. Sleep disruption in Parkinson’s disease; assessment by continuous activity monitoring. Acta Neurol. 1994;51:922–8.

    Google Scholar 

  35. Tosini G, Pozdeyev N, Sakamoto K, Iuvone PM. The circadian clock system in the mammalian retina. Bioessays. 2008;l30(7):624–33.

    Article  CAS  Google Scholar 

  36. Nguyen-Legros J, Harnois C, Di Paolo T, Simon A. The retinal dopamine system in Parkinson’s disease. Clin Vis Sci. 1993;8(1):1–12.

    Google Scholar 

  37. Inzelberg R, Ramirez JA, Nisipeanu P, Ophir A. Retinal nerve fiber layer thinning in Parkinson’s disease. Vision Res. 2004;44(24):2793–7.

    Article  PubMed  Google Scholar 

  38. Willis GL, Turner EJ. Primary and secondary features of Parkinson’s disease improved with strategic exposure to bright light: a case series study. Chronobiol Int. 2007;24(3):521–37.

    Article  PubMed  Google Scholar 

  39. Paus S, Schimtz-Hubsch T, Wullner U, Vogel A, Klockgether T, Abele M. Bright light therapy in Parkinson’s disease: a pilot study. Mov Disord. 2007;22(10):1495–8.

    Article  PubMed  Google Scholar 

  40. Arnulf I, Konofal E, Merino-Andreu M, Hoeuto JL, Mesnage V, Welter ML, Lacoblez L, Golmard JL, Derenne JP, Agid Y. Parkinson’s disease and sleepiness: an integral part of PD. Neurology. 2002;68(7): 1019–24.

    Article  Google Scholar 

  41. Fronczek R, Overeem S, Lee SYY, Hegeman IM, van Pelt J, van Duinen SG, Lammers GJ, Swaab DF. Hypocretin (orexin) loss in Parkinson’s disease. Brain. 2007;130:1577–85.

    Article  PubMed  Google Scholar 

  42. Asai H, Hirano M, Furiya Y, Udaka F, Morikawa M, Kabayashi T, Shimizu T, Uenu S. Cerebrospinal fluid-orexin levels and sleep attacks in four patients with Parkinson’s disease. Clin Neurol Neurosurg. 2009;111(4):341–4.

    Article  PubMed  Google Scholar 

  43. Lessig S, Ubhi K, Galasko D, Adame A, Phan E, Remidios K, Chang M, Hansen LA, Masliah E. Reduced hypocretin (orexin) levels in dementia with Lewy bodies. Neuroreport. 2010;21(11):756–60.

    Article  PubMed  Google Scholar 

  44. Overeem S, van Hilten JJ, Ripley BS, et al. Normal hypocretin-1 levels in Parkinson’s disease patients with excessive daytime sleepiness. Neurology. 2002;58:494–8.

    Article  Google Scholar 

  45. Baumann C, Ferini-Strambi L, Waldvogel D, Werth E, Bassetti CL. Parkinsonism with excessive daytime sleepiness – a narcolepsy-like disorder? J Neurol. 2005;252(2):139–45.

    Article  PubMed  Google Scholar 

  46. Compta Y, Santamaria J, Ratti L, Tolosa E, Iranzo A, Munoz E, et al. Cerebrospinal hypocretin, daytime sleepiness, and sleep architecture in Parkinson’s disease dementia. Brain. 2009;132:3308–17.

    Article  PubMed  Google Scholar 

  47. Lu J, Zhang YH, Chou TC, Gaus SE, Elmquist JK, Shiromani P, Sapir CB. Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation. J Neurosci. 2001;21: 4864–74.

    PubMed  CAS  Google Scholar 

  48. Moorman DE, Aston-Jones G. Orexin/hypocretin modulates response of ventral tegmental dopamine neurons in prefrontal activation: diurnal influences. J Neurosci. 2010;30(46):1–18.

    Article  CAS  Google Scholar 

  49. Senthilvel E, Auckley D, Dasarathy J. Evaluation of sleep disorders in the primary care setting: history taking compared for questionnaires. J Clin Sleep Med. 2011;7(1):41–8.

    PubMed  Google Scholar 

  50. Shapira AHV. Sleep attacks (sleep episodes) with pergolide. Lancet. 2000;355:1331–2.

    Article  Google Scholar 

  51. Ferriera JJ, Galitsky M, Montastruc JL, Rascol O. Sleep attacks and disease treatment. Lancet. 2000;355:1333–4.

    Article  Google Scholar 

  52. Tan EK, Lum SY, Fook-Chong SMC, et al. Evaluating of somnolence in Parkinson’s disease: comparison with age and sex matched controls. Neurology. 2002;58:465–8.

    Article  PubMed  CAS  Google Scholar 

  53. Hogl B, Arnulf I, Comella C, et al. Scales to assess sleep impairment in Parkinson’s disease: critique and recommendations. Mov Disord. 2010;25(16):2706–16.

    Article  Google Scholar 

  54. Trenkwalder C, Kohnen R, Hogl B, Metta V, Sixel-Doring F, Fruascher B, Hulsmann J, Martinez-Martin P, Chaudhuri KR. Parkinson’s disease sleep scale – validation of the revised version PDSS-2. Mov Disord. 2011;26(4):644–52.

    Article  PubMed  Google Scholar 

  55. Stavitsky K, Saurman JL, McNamara P, Cronin-Golomb A. Sleep in Parkinson’s disease: a comparison of actigraphy and subjective measures. Parkinsonism Relat Disord. 2010;16(4):280–3.

    Article  PubMed  CAS  Google Scholar 

  56. Morganthaler TI, Lee Chiong T, Alessi C, et al. Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. An American Academy of Sleep Medicine report. Sleep. 2007;30:1445–59.

    Google Scholar 

  57. Taft M. Genetic aspects of normal and disturbed sleep. Sleep Med. 2009;10 Suppl 1:S17–21.

    Article  Google Scholar 

  58. Mignot E. Genetic and familial aspects of narcolepsy. Neurology. 1998;50(2 suppl 1):S16–22.

    Article  PubMed  CAS  Google Scholar 

  59. American Academy of Sleep Medicine. The International Classification of Sleep Disorders, Diagnostic and Coding Manual. 2nd ed. Westchester, IL: American Academy of Sleep Medicine; 2005.

    Google Scholar 

  60. Black J, Pardi D, Hornfeldt CS, Inhaber N. The nightly use of sodium oxybate is associated with a reduction in nocturnal sleep disruption: a double-blind placebo-controlled study in patients with narcolepsy. J Clin Sleep Med. 2010;6(6):596–602.

    PubMed  Google Scholar 

  61. Hogl B, Saletu M, Brandauer E, et al. Modafinil for the treatment of daytime sleepiness in Parkinson’s disease: a double-blind randomized, crossover, placebo-controlled polygraphic trial. Sleep. 2002;25:905–9.

    PubMed  CAS  Google Scholar 

  62. Adler CH, Caviness JN, Hentz JG, Lind M, Tiede J. Randomized trial of modafinil for treating daytime sleepiness in patients with Parkinson’s disease. Mov Disord. 2003;18:287–93.

    Article  PubMed  Google Scholar 

  63. Ondo WG, Fayle R, Atass F, Jankovic J. Modafinil for daytime somnolence in Parkinson’s disease: double blinded placebo controlled parallel trial. J Neurol Neurosurg Psychiatry. 2005;76:1636–9.

    Article  PubMed  CAS  Google Scholar 

  64. Lokk J. Daytime sleepiness in elderly Parkinson’s disease patients and treatment with the psychostimulant modafinil: a preliminary study. Neuropsychiatr Dis Treat. 2010;6:93–7.

    Article  PubMed  Google Scholar 

  65. Lemke MR, Fuchs G, Gemende I, Herting B, Oehlwein C, Reichmann H, Rieke J, Volkmann J. Depression and Parkinson’s disease. J Neurol. 2004;251 Suppl 6:VI/24–7.

    Google Scholar 

  66. Aarsland D, Påhlhagen S, Ballard CG, Ehrt U, Svenningsson P. Depression in Parkinson disease-epidemiology, mechanisms and management. Nat Rev Neurol. 2011;8(1):35–47.

    Article  PubMed  CAS  Google Scholar 

  67. Riedel O, Klotsche J, Spottke A, Deuschl G, Förstl H, Henn F, Heuser I, Oertel W, Reichmann H, Riederer P, Trenkwalder C, Dodel R, Wittchen HU. Cognitive impairment in 873 patients with idiopathic Parkinson’s disease. Results from the German Study on Epidemiology of Parkinson’s Disease with Dementia (GEPAD). J Neurol. 2008;255(2):255–64.

    Article  PubMed  Google Scholar 

  68. Goetz CG, Vogel C, Tanner CM, Stebbins GT. Early dopaminergic drug-induced hallucinations in parkinsonian patients. Neurology. 1998;51(3):811–4.

    Article  PubMed  CAS  Google Scholar 

  69. Nalaka S. Effect of ramelteon for insomnia in older adults with obstructive sleep apnea: a randomized placebo controlled pilot study. J Clin Sleep Med. 2010;6(6):572–80.

    Google Scholar 

  70. Deschenes CL, McCurry S. Current treatments for sleep disturbances in individuals with dementia. Curr Psychiatry Rep. 2009;11(1):20–6.

    Article  PubMed  Google Scholar 

  71. Menza M, Dobkin RD, Marin H, Gara M, Bienfait K, Dicke A, Comella CL, Cantor C, Hyer L. Treatment of insomnia in Parkinson’s disease: a controlled trial of eszopiclone and placebo. Mov Disord. 2010;25(11):1708–14.

    Article  PubMed  Google Scholar 

  72. Ondo WG, Perking T, Swick T, Hull Jr KL, Jimenez JE, Garris TS, Pardi D. Sodium oxybate for excessive daytime sleepiness in Parkinson’s disease: an open label polysomnographic study. Arch Neurol. 2008;65(10):1337–40.

    Article  PubMed  Google Scholar 

  73. Luria A. Obstructive sleep apnea in adults: epidemiology, clinical presentation, and treatment options. Adv Cardiol. 2011;46:1–42.

    Article  Google Scholar 

  74. Diederich NJ, Vaillant M, Leischen M, Mancuso G, Golinval S, Nati R, Schlesser M. Sleep apnea syndrome in Parkinson’s disease; A case-control study in 49 patients. Mov Disord. 2005;20(11):1413–8.

    Article  PubMed  Google Scholar 

  75. Luria A. Cardiovascular disorders associated with obstructive sleep apnea. Adv Cardiol. 2011;46:197–266.

    Article  Google Scholar 

  76. Beebe DW, Groesz L, Wells C, Nichols A, McGree K. The neuropsychological effects of obstructive sleep apnea: a meta- analysis of norm-referenced and case controlled data. Sleep. 2003;26:298–307.

    PubMed  Google Scholar 

  77. Tregear S, Reston J, Schoellles K, Phillips B. Obstructive sleep apnea and risk of motor vehicle crash: systematic review and meta-analysis. J Clin Sleep Med. 2009;5(6):573–81.

    PubMed  Google Scholar 

  78. Aloia MS, Ilniczky N, Di Dio P, Perlis ML, Greenblatt DW, Giles DF. Neuropsychological changes and treatment compliance in older adults with sleep apnea. J Psychosom Res. 2003;54:71–6.

    Article  PubMed  Google Scholar 

  79. George CF. Reduction in motor vehicle collisions following treatment of sleep apnoea with nasal CPAP. Thorax. 2001;56(7):508–12.

    Article  PubMed  CAS  Google Scholar 

  80. Tregear S, Reston J, Schoelles K, Phillips B. Continuous positive airway pressure reduces risk of motor vehicle crash among drivers with obstructive sleep apnea: systematic review and meta-analysis. Sleep. 2010;33(10):1373–80.

    PubMed  Google Scholar 

  81. Egea CJ, Aizpuru F, Pinto JA, Ayuela JM, Ballester E, Zamarrón C, Sojo A, Montserrat JM, Barbe F, Alonso-Gomez AM, Rubio R, Lobo JL, Duran-Cantolla J, Zorrilla V, Nuñez R, Cortés J, Jiménez A, Cifrián J, Ortega M, Carpizo R, Sánchez A, Terán J, Iglesias L, Fernández C, Alonso ML, Cordero J, Roig E, Pérez F, Muxi A, Gude F, Amaro A, Calvo U, Masa JF, Utrabo I, Porras Y, Lanchas I, Sánchez E, Spanish Group of Sleep Breathing Disorders. Cardiac function after CPAP therapy in patients with chronic heart failure and sleep apnea: a multicenter study. Sleep Med. 2008;9(6):660–6.

    Article  PubMed  Google Scholar 

  82. Kneisley LW, Rederich GL. Nocturnal stridor in olivopontocerebellar atrophy. Sleep. 1990;13(4):362–8.

    PubMed  CAS  Google Scholar 

  83. Vetrugno R, Liguori R, Cortelli P, et al. Sleep-related stridor due to dystonic vocal cord motion and neurogenic tachypnea/tachycardia in MSA. Mov Disord. 2007;22(5):673–8.

    Article  PubMed  Google Scholar 

  84. Blumin JH, Berke GS. Bilateral vocal fold paresis and multiple system atrophy. Arch Otolaryngol Head Neck Surg. 2002;28(12):404–7.

    Google Scholar 

  85. Philips B, Young T, Finn L, Asher K, Hening WA, Purvis C. Epidemiology of restless legs symptoms in adults. Arch Intern Med. 2000;160(4):2137–41.

    Article  Google Scholar 

  86. Yeh P, Walters AS, Tsuang JW. Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment. Sleep Breath. 2012 doi: 10.1007/S11325-011-0606-X.

    Google Scholar 

  87. Peralta CM, Frauscher B, Seppi K, Wolf E, Wenning GK, Hogl B, Poewe W. Restless legs syndrome in Parkinson’s disease. Mov Disord. 2009;24(14):2076–80.

    Article  PubMed  Google Scholar 

  88. Gjerstad MD, Tysnes OB, Larsen JP. Increased risk of leg motor restlessness but not RLS in early Parkinson’s disease. Neurology. 2011;77(22):1941–6.

    Article  PubMed  CAS  Google Scholar 

  89. Gao X, Schwarzschild MA, O’Reilly EJ, Wang H, Ascherio A. Restless legs syndrome and Parkinson’s disease in men. Mov Disord. 2010;25(15):2654–7.

    Article  PubMed  Google Scholar 

  90. Abetz L, Allen R, Follet A, Washburn T, Earley C, Kirsch J, Knight H. Evaluating the quality of life of patients with restless legs syndrome. Clin Ther. 2004;26(6):925–35.

    Article  PubMed  Google Scholar 

  91. Allen RP, Walters AS, Montplaisir J, Hening W, Myers A, Bell TJ, Ferini-Strambi L. Restless legs syndrome prevalence and impact: REST general population study. Arch Intern Med. 2005;165(11):1286–92.

    Article  PubMed  Google Scholar 

  92. Valko PO, Siccoli MM, Bassetti CL. Unilateral RLS with predominantly ipsilateral PLMS and variable response to dopaminergic drugs: a variant of idiopathic RLS? Eur J Neurol. 2009;16(3):430–2.

    Article  PubMed  CAS  Google Scholar 

  93. Earley CJ, Allen RP, Connor JR, Ferrucci L, Troncoso J. The dopaminergic neurons of the A11 system in RLS autopsy brains appear normal. Sleep Med. 2009;10(10):1155–7.

    Article  PubMed  Google Scholar 

  94. O’Keefe ST, Noel J, Lavan JN. Restless legs syndrome in the elderly. Postgrad Med J. 1993;69:701–3.

    Article  Google Scholar 

  95. Mizuno S, Mihara T, Miyaoka T, Inagaki T, Horiguchi J. CSF iron, ferritin and transferrin levels in restless legs syndrome. J Sleep Res. 2005;14(1):43–7.

    Article  PubMed  Google Scholar 

  96. Earley CJ, Connor JR, Beard JL, Clardy SL, Allen RP. Ferritin levels in the cerebrospinal fluid and restless legs syndrome: effects of different clinical phenotypes. Sleep. 2005;28(9):1069–75.

    PubMed  Google Scholar 

  97. Allen RP, Barker PB, Wehrl F, Song HK, Earley CJ. MRI measurement of brain iron in patients with restless legs syndrome. Neurology. 2001;56(2):263–5.

    Article  PubMed  CAS  Google Scholar 

  98. O’Keefe ST, Gavan K, Lavan JN. Iron status and restless leg syndrome in the elderly. Age Ageing. 1994;23(3):200–3.

    Article  Google Scholar 

  99. Early CJ. Clinical practice. Restless legs syndrome. N Engl J Med. 2003;348(21):2103–9.

    Article  Google Scholar 

  100. Lee JE, Shin HW, Kim KS, Sohn YH. Factors contributing to the development of restless legs syndrome in patients with Parkinson’s disease. Mov Disord. 2009;24(4):579–82.

    Article  PubMed  Google Scholar 

  101. Ondo WG, Vuong KD, Jankovic J. Exploring the relationship between Parkinson’s disease and restless legs syndrome. Arch Neurol. 2002;59(3):421–4.

    Article  PubMed  Google Scholar 

  102. Hening WA, Allen RP, Ondo WG, Walters AS, Winkelman JW, Becker P, Bogan R, Fry JM, Kudrow DB, Lesh KW, Fichtner A, Schollmayer E, SP792 Study Group. Rotigotine improves restless legs syndrome: a 6-month randomized, double-blind, placebo-controlled trial in the United States. Mov Disord. 2010;25(11):1675–83.

    Article  PubMed  Google Scholar 

  103. Hauser RA, Schapira AH, Rascol O, Barone P, Mizuno Y, Salin L, Haaksma M, Juhel N, Poewe W. Randomized, double-blind, multicenter evaluation of pramipexole extended release once daily in early Parkinson’s disease. Mov Disord. 2010;25(15):2542–9.

    Article  PubMed  Google Scholar 

  104. Manconi M, Ferri R, Zucconi M, Oldani A, Giarolli L, Bottasini V, Ferini-Strambi L. Pramipexole versus ropinirole: polysomnographic acute effects in restless legs syndrome. Mov Disord. 2011;26(5):892–5.

    Article  PubMed  Google Scholar 

  105. Allen R, Chen C, Soaita A, Wohlberg C, Knapp L, Peterson BT, García-Borreguero D, Miceli J. A randomized, double-blind, 6-week, dose-ranging study of pregabalin in patients with restless legs syndrome. Sleep Med. 2010;11(6):512–9.

    Article  PubMed  Google Scholar 

  106. Winkelman JW, Bogan R, Schmidt MH, Hudson JD, DeRossett SE, Hill-Zabala C. Randomized polysomnography study of gabapentin enacarbil in subjects with restless legs syndrome. Mov Disord. 2011;26(11):2065–72.

    Article  PubMed  Google Scholar 

  107. Walters AS, Winkelman J, Trenkwalder C, Fry JM, Kataria V, Wagner M, Sharma R, Hening W, Li L. Long-term follow up on restless legs syndrome patients treated with opioids. Mov Disord. 2001;16(6):1105–9.

    Article  PubMed  CAS  Google Scholar 

  108. Ondo WG. Methadone for refractory restless legs syndrome. Mov Disord. 2005;20(1):345–8.

    Article  PubMed  Google Scholar 

  109. Covassin N, Neikrug AB, Liu L, Corey-Bloom J, Loredo JS, Palmer BW, Maglione J, Ancoli-Israel S. Clinical correlates of periodic limb movements in sleep in Parkinson’s disease. J Neurol. 2012;316(1–2):131–6. Abstract.

    Google Scholar 

  110. Mahowald MW, Schenck C. REM sleep disorder. In: Kryger M, Roth T, Dement W, editors. Principles and practice in sleep medicine. 2nd ed. Philadelphia, PA: W. B. Saunders; 1994. p. 574–88.

    Google Scholar 

  111. Tison F, Wenning GK, Quinn NP. REM sleep behavior disorder as the presenting symptom of multiple system atrophy. J Neurol Neurosurg Psychiatry. 1995;58:379–80.

    Article  PubMed  CAS  Google Scholar 

  112. Olson EJ, Boeve BF, Silber MH. Rapid eye movement sleep behavior disorder: demographic, clinical and laboratory findings in 93 cases. Brain. 2000;123:331–9.

    Article  PubMed  Google Scholar 

  113. Sixel-Doring F, Trautmann E, Mollenhauer B, Trenkwalder C. Associated factors for REM sleep behavior disorder in Parkinson’s disease. Neurology. 2011;77:1048–54.

    Article  PubMed  CAS  Google Scholar 

  114. Eisensehr I, Lindeiner H, Jager M, Noachtar S. REM sleep behavior disorder in sleep-disordered patients with versus without Parkinson’s disease: is there a need for polysomnography? J Neurol Sci. 2001;1(86):7–11.

    Article  Google Scholar 

  115. Boeve BF. REM behavior sleep disorder: updated review of the core features, the RBD – Neurodegenerative Disease Association, evolving concepts, controversies and future directions. Ann NY Acad Sci. 2010;1184:15–54.

    Article  PubMed  CAS  Google Scholar 

  116. Iranzo A, Valldeoriola F, Santamaria J, Tolosa E, Rumia J. Sleep symptoms and polysomnographic architecture in advanced Parkinson’s disease after chronic bilateral subthalamic stimulation. J Neurol Neurosurg Psychiatry. 2002;72:661–4.

    Article  PubMed  CAS  Google Scholar 

  117. Onofrj M, Luciano AL, Thomas A, Iacono D, D’Andreamatteo G. Mirtazapine induces REM sleep behavior disorder in parkinsonism. Neurology. 2003;60(1):113–5.

    Article  PubMed  CAS  Google Scholar 

  118. Winkelman JW, James L. Serotonergic antidepressants are associated with REM sleep without atonia. Sleep. 2004;27(2):317–21.

    PubMed  Google Scholar 

  119. Frucht S, Rogers JD, Greene PE, et al. Falling asleep at the wheel: motor vehicle mishaps in persons taking pramipexole and ropinirole. Neurology. 1999;52:1908–10.

    Article  PubMed  CAS  Google Scholar 

  120. Korner Y, Meindorfner C, Moller JC, Stiasny-Kolster K, Haja D, Cassel W, Oertel WH, Kruger HP. Predictors of sudden onset of sleep in Parkinson’s disease. Mov Disord. 2004;19(11):1298–305.

    Article  PubMed  Google Scholar 

  121. Hoehn MM. Falling asleep at the wheel: motor vehicle mishaps in people taking pramipexole and ropinirole [comment]. Neurology. 2000;52:275.

    Google Scholar 

  122. Montastruc JL, Brefel-Courbon C, Senard JM, Bagheri H, Ferreira J, Rascol O, Lapeyre-Mestre M. Sleep attacks and antiparkinsonian drugs: a pilot prospective pharmacoepidemiological study. Clin Neuropharmacol. 2001;24:181–3.

    Article  PubMed  CAS  Google Scholar 

  123. Lang AE, Hobson DE, Martin W, Rives J. Excessive daytime sleepiness and sudden onset sleep in Parkinson’s disease: a survey from 16 Canadian movement disorder clinics. Neurology. 2001;56:S40.001.

    Google Scholar 

  124. Ferreira JJ, Desboeuf K, Galitzky M, et al. Sleep disruption, daytime somnolence and “sleep attacks” in Parkinson’s disease: a clinical survey in PD patients and age-matched healthy volunteers. Eur J Neurol. 2006;13:209–14.

    Article  PubMed  CAS  Google Scholar 

  125. Homann CN, Wenzel K, Suppan K, Ivanic G, Kriechbaum N, Crevenna R, Ott E. Sleep attacks in patients taking dopamine agonists: review. BMJ. 2002;324:1483–7.

    Article  PubMed  CAS  Google Scholar 

  126. Rissling I, Geller F, Bandmann O, Stiasny-Kolster K, Korner Y, Meindorfner C, Kruger HP, Oertel WH, Moller JC. Dopamine receptor gene polymorphism in Parkinson’s disease patients reporting “sleep attacks”. Mov Disord. 2004;19(11):1279–84.

    Article  PubMed  Google Scholar 

  127. Paul S, Brecht HM, Koster J, Seeger G, Klockgether T, Wullner U. Sleep attacks, daytime sleepiness, and dopamine agonists in Parkinson’s disease. Mov Disord. 2003;18(6):659–67.

    Article  Google Scholar 

  128. Bares M, Kanovský P, Rektor I. Excessive daytime sleepiness and ‘sleep attacks’ induced by entacapone. Fundam Clin Pharmacol. 2003;17(1):113–6.

    Article  PubMed  CAS  Google Scholar 

  129. George C. Sleep: driving and automobile crashes in patients with obstructive sleep apnea/hypopnea syndrome. Thorax. 2004;59(9):804–7.

    Article  PubMed  CAS  Google Scholar 

  130. Wood JM, Worringham C, Kerr G, Mallon K, Silburn P. Quantitative assessment of driving performance in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2005;76:176–80.

    Article  PubMed  CAS  Google Scholar 

  131. Heikkila VM, Turkka J, Korpelainen J, Kailaranta T, Summala H. Decreased driving ability in people with Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1998;64:325–30.

    Article  PubMed  CAS  Google Scholar 

  132. Uc EY, Rizzo M, Anderson SW, Dastrup E, Sparks JD, Dawson JD. Driving under low-contrast visibility conditions in Parkinson’s disease. Neurology. 2009;73:1103–10.

    Article  PubMed  CAS  Google Scholar 

  133. Nabi H, Gueguen A, Chiron M, Lafont S, Zins M, Lagarde E. Awareness of driving while sleepy and road traffic accidents; prospective study in GAZEL cohort. BMJ. 2006;333(7558):75.

    Article  PubMed  Google Scholar 

  134. Uc EY, Rizzo M, Johnson AM, Datrup E, Anderson SW, Dawson JD. Road safety in drivers with Parkinson’s disease. Neurology. 2009;73:2112–9.

    Article  PubMed  CAS  Google Scholar 

  135. Amara AW, Watts RL, Walker HC. The effects of deep brain stimulation on sleep in Parkinson’s disease. Ther Adv Neurol Dis. 2011;4(1):15–24.

    Article  Google Scholar 

  136. Arnulf I, Bejjani BP, Garma L, Bonnet AM, Houeto JL, Damier P, et al. Improvement of sleep architecture in PD with subthalamic nucleus stimulation. Neurology. 2000;55:1732–4.

    Article  PubMed  CAS  Google Scholar 

  137. Cicolin A, Lopiano L, Zibetti M, Torre E, Tavella A, Guastamacchia G, et al. Effects of deep brain stimulation of the subthalamic nucleus on sleep architecture in Parkinson’s disease. Sleep Med. 2004;5(2):207–10.

    Article  PubMed  Google Scholar 

  138. Lyons KE, Pahwa R. Effects of bilateral subthalamic nucleus stimulation on sleep, daytime sleepiness, and early morning dystonia in patients with Parkinson’s disease. J Neurosurg. 2006;104:502–5.

    Article  PubMed  Google Scholar 

  139. Amara A, Walker H, Guthrie S, Cutter G, Standaert D, Watts RL (2010) Unilateral STN DBS improves sleep in Parkinson’s disease. In American Academy of Neurology annual meeting, 15 Apr 2010. Toronto, ON: American Academy of Neurology.

    Google Scholar 

  140. Rodriguez JP, Walters SE, Watson P, Stell R, Mastaglia FL. Globus pallidus stimulation improves both motor and nonmotor aspects of quality of life in advanced Parkinson’s disease. Mov Disord. 2007;22:1866–70.

    Article  Google Scholar 

  141. Volkmann J, Albanese A, Kulisevsky J, Tornqvist AL, Houeto JL, Pidoux B, et al. Long term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson’s disease. Mov Disord. 2009;24:1154–61.

    Article  PubMed  Google Scholar 

  142. Favre J, Burchiel KJ, Taha JM, Hammerstad J. Outcome of unilateral and bilateral pallidotomy for Parkinson’s disease: patient assessment. Neurosurgery. 2000;46:344–53. Discussion 353–5.

    Article  PubMed  CAS  Google Scholar 

  143. Lim AS, Moro E, Lozano AM, Hamani C, Dostrovsky JO, Hutchison WD, et al. Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human pons. Ann Neurol. 2009;66:110–4.

    Article  PubMed  Google Scholar 

  144. Romigi A, Placidi F, Peppe A, Pierantozzi M, Izzi F, Brusa L. Pedunculopontine nucleus stimulation influences REM sleep in Parkinson’s disease. Eur J Neurol. 2008;15:e64–5.

    Article  PubMed  CAS  Google Scholar 

  145. Alessandro S, Ceravolo R, Brusa L, Pierantozzi M, Costa A, Galati S, et al. Non-motor function in parkinsonian patients implanted in the pedunculopontine nucleus: focus on sleep and cognitive domains. J Neurol Sci. 2010;249:44–8.

    Article  Google Scholar 

  146. Arnulf I, Ferraye M, Fraix V, Benabid AL, Houeto JL, Damier P, et al. Sleep induced by stimulation in the human pedunculopontine nucleus area. Ann Neurol. 2010;67:546–9.

    Article  PubMed  Google Scholar 

  147. van Dijk KD, Most EI, Van Someren EJ, Berendse HW, Van der Werf YD. Beneficial effect of transcranial magnetic stimulation on sleep in Parkinson’s disease. Mov Disord. 2009;24(6):878–84.

    Article  PubMed  Google Scholar 

  148. Shill HA, Obradov S, Katsnelson Y, Pizinger R. A randomized double blind trial of transcranial electrostimulation in early Parkinson’s disease. Mov Disord. 2011;26(8):1477–80.

    Article  PubMed  Google Scholar 

  149. Arias P, Vivas J, Grieve KL, Cudeiro J. Double blind, randomized, placebo controlled trial on the effect of 10 days low frequency rTMS over the vertex on sleep in Parkinson’s disease. Sleep Med. 2010;11(8): 759–65.

    Article  PubMed  Google Scholar 

  150. Shulman LM, Wen X, Weiner WJ, Bateman D, Minagar A, Duncan R, Konefal J. Acupuncture therapy for the symptoms of Parkinson’s disease. Mov Disord. 2002;17:799–802.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Neurology, Department of Medicine, Maimonides Medical Center, Brooklyn, NY, USA

    Daryl J. Victor M.D.

  2. Movement Disorders, Department of Neurology, Mount Sinai Medical Center, 5 East 98th Street, Lobby Level, 1138, New York, NY, 10029, USA

    Steven Frucht M.D.

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  1. Daryl J. Victor M.D.
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  2. Jack Janani M.D.
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  3. Steven Frucht M.D.
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Correspondence to Steven Frucht M.D. .

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Editors and Affiliations

  1. Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA

    Ronald F. Pfeiffer (Professor and Vice Chair) (Professor and Vice Chair)

  2. Parkinson’s Disease and Related Disorders Clinic, SUNY Downstate Medical Center, Brooklyn, NY, USA

    Ivan Bodis-Wollner

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Victor, D.J., Janani, J., Frucht, S. (2013). Excessive Daytime Sleepiness in Parkinson’s Disease. In: Pfeiffer, R.F., Bodis-Wollner, I. (eds) Parkinson’s Disease and Nonmotor Dysfunction. Current Clinical Neurology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-429-6_19

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