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Colorectal Cancer Pathways

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Colorectal Cancer Screening

Part of the book series: Clinical Gastroenterology ((CG))

Abstract

Genomic instability is a hallmark of colorectal cancer. Progressive accumulation of mutations leads to deregulation of cellular events, acquired growth advantage, and clonal expansion of abnormal cells. Subsequently, these cells become more susceptible to mutations increasing the likelihood of critical mutations and giving rise to histopathologically identifiable neoplastic growth and metastatic behavior.

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Author information

Authors and Affiliations

  1. Department of Medicine, Division of Digestive Diseases, Yale University and VA Connecticut Healthcare System, West Haven Campus, 333 Cedar Street, 208056, New Haven, CT, 06520-8056, USA

    Petr Protiva

Authors
  1. Petr Protiva
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Correspondence to Petr Protiva .

Editor information

Editors and Affiliations

  1. Division of Gastroenterology, University of Connecticut, 263 Farmington Avenue, Farmington, 06030, USA

    Joseph Anderson, MD

  2. Indiana University School of Medicine, 1481 W 10th street, 111G, Indianapolis, 46202, USA

    Charles Kahi, MD

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Protiva, P. (2011). Colorectal Cancer Pathways. In: Anderson, MD, J., Kahi, MD, C. (eds) Colorectal Cancer Screening. Clinical Gastroenterology. Humana Press. https://doi.org/10.1007/978-1-60761-398-5_1

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  • DOI: https://doi.org/10.1007/978-1-60761-398-5_1

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-397-8

  • Online ISBN: 978-1-60761-398-5

  • eBook Packages: MedicineMedicine (R0)

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