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Endocrinologic Sequelae of Anorexia Nervosa

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Pediatric Endocrinology

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

Anorexia nervosa (AN) is a severe psychiatric and medical condition once described as the “relentless pursuit of thinness.” Eighty-five percent of patients with AN present between the ages of 13 and 20 years during a critical period for growth, pubertal development, and maximal bone accretion that culminates in peak bone mass. The disorder can result in a compromise in each of these important endocrinologic events, with lifelong sequelae. Recent trends demonstrate an earlier age of onset of AN, and it is recognized that onset at a younger age is associated with poorer growth and bone health outcomes. Patients with AN also have a characteristic clinical picture of endocrine dysfunction, including amenorrhea, abnormal temperature regulation, elevated growth hormone (GH) levels, hypercortisolemia, and abnormal eating suggestive of hypothalamic or pituitary dysfunction. Therefore, endocrine function has been studied extensively in these patients. The multiple endocrine abnormalities appear to represent an adaptation to the starvation state.

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Authors and Affiliations

  1. Division of Endocrinology, Boston Children’s Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA

    Lisa Swartz Topor M.D., M.M.Sc.

  2. Divisions of Adolescent Medicine and Endocrinology, Hasbro Children’s Hospital, Alpert Medical School of Brown University, Providence, RI, USA

    Catherine M. Gordon M.D., M.M.Sc.

  3. Research Associate, Boston Children’s Hospital, Boston, MA, USA

    Catherine M. Gordon M.D., M.M.Sc.

  4. Adolescent Medicine, Boston Children’s Hospital, Boston, MA, USA

    Estherann Grace M.D.

Authors
  1. Lisa Swartz Topor M.D., M.M.Sc.
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  2. Catherine M. Gordon M.D., M.M.Sc.
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  3. Estherann Grace M.D.
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Corresponding author

Correspondence to Lisa Swartz Topor M.D., M.M.Sc. .

Editor information

Editors and Affiliations

  1. School of Medicine, Department of Pediatrics, The Johns Hopkins University, 600 North Wolfe St., Baltimore, 21287, Maryland, USA

    Sally Radovick

  2. , Department of Pediatrics, Children's Hospital of Buffalo, 219 Bryant St., Buffalo, 14222, New York, USA

    Margaret H. MacGillivray

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Topor, L.S., Gordon, C.M., Grace, E. (2013). Endocrinologic Sequelae of Anorexia Nervosa. In: Radovick, S., MacGillivray, M. (eds) Pediatric Endocrinology. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-395-4_11

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  • DOI: https://doi.org/10.1007/978-1-60761-395-4_11

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