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Histiocytic and Dendritic Cell Neoplasms

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Neoplastic Hematopathology

Part of the book series: Contemporary Hematology ((CH))

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This chapter covers tumors of the monocytic and dendritic cell lineage and those that arise from the reticular network of lymph node and extranodal lymphoid tissues (i.e. Waldeyer’s ring and gut lymphoid tissue), including follicular dendritic cell sarcoma and fibroblastic reticular cell sarcoma. Mature/fully-differentiated histiocytic/dendritic cell neoplasms include Langerhans cell histiocytosis, its malignant counterpart Langerhans cell sarcoma, and the related S100-negative histiocytoses. Immature malignancies in this group include myeloid and monocytic leukemia presenting first in extramedullary tissues, and the newly recognized blastic plasmacytoid dendritic cell neoplasm.

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References

  1. Swerdlow SH, Campo E, Harris NL, et al., eds. WHO classification of tumours of hematopoietic and lymphoid tissues. Lyon: IARC, 2008.

    Google Scholar 

  2. Ito T, Liu YJ, Kadowaki N. Functional diversity and plasticity of human dendritic cell subsets. Int J Hematol 2005;81:188-96.

    Article  PubMed  CAS  Google Scholar 

  3. Grouard G, Rissoan MC, Filgueira L, Durand I, Banchereau J, Liu YJ. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med 1997;185:1101-11.

    Article  PubMed  CAS  Google Scholar 

  4. Cella M, Jarrossay D, Facchetti F, et al. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med 1999;5:919-23.

    Article  PubMed  CAS  Google Scholar 

  5. Angel CE, Chen CJ, Horlacher OC, et al. Distinctive localization of antigen-presenting cells in human lymph nodes. Blood 2009;113:1257-67.

    Article  PubMed  CAS  Google Scholar 

  6. Chu T, D’Angio GJ, Favara BE, Ladisch S, Nesbit M, Pritchard J. Histiocytosis syndromes in children. Lancet 1987;2:41-2.

    Article  PubMed  CAS  Google Scholar 

  7. Howarth DM, Gilchrist GS, Mullan BP, Wiseman GA, Edmonson JH, Schomberg PJ. Langerhans cell histiocytosis: diagnosis, natural history, management, and outcome. Cancer 1999;85:2278-90.

    Article  PubMed  CAS  Google Scholar 

  8. Yousem SA, Colby TV, Chen YY, Chen WG, Weiss LM. Pulmonary Langerhans’ cell histiocytosis: molecular analysis of clonality. Am J Surg Pathol 2001;25:630-6.

    Article  PubMed  CAS  Google Scholar 

  9. Pileri SA, Grogan TM, Harris NL, et al. Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology 2002;41:1-29.

    Article  PubMed  CAS  Google Scholar 

  10. Lau SK, Chu PG, Weiss LM. Immunohistochemical expression of Langerin in Langerhans cell histiocytosis and non-Langerhans cell histiocytic disorders. Am J Surg Pathol 2008;32:615-9.

    Article  PubMed  Google Scholar 

  11. Pinkus GS, Lones MA, Matsumura F, Yamashiro S, Said JW, Pinkus JL. Langerhans cell histiocytosis immunohistochemical expression of fascin, a dendritic cell marker. Am J Clin Pathol 2002;118:335-43.

    Article  PubMed  CAS  Google Scholar 

  12. Willman CL, Busque L, Griffith BB, et al. Langerhans’-cell histiocytosis (histiocytosis X) - a clonal proliferative disease. N Engl J Med 1994;331:154-60.

    Article  PubMed  CAS  Google Scholar 

  13. Murakami I, Gogusev J, Fournet JC, Glorion C, Jaubert F. Detection of molecular cytogenetic aberrations in Langerhans cell histiocytosis of bone. Hum Pathol 2002;33:555-60.

    Article  PubMed  CAS  Google Scholar 

  14. Rust R, Kluiver J, Visser L, et al. Gene expression analysis of dendritic/Langerhans cells and Langerhans cell histiocytosis. J Pathol 2006;209:474-83.

    Article  PubMed  CAS  Google Scholar 

  15. Arico M, Girschikofsky M, Genereau T, et al. Langerhans cell histiocytosis in adults. Report from the International Registry of the Histiocyte Society. Eur J Cancer 2003;39:2341-8.

    Article  PubMed  CAS  Google Scholar 

  16. Gadner H, Grois N, Arico M, et al. A randomized trial of treatment for multisystem Langerhans’ cell histiocytosis. J Pediatr 2001;138:728-34.

    Article  PubMed  CAS  Google Scholar 

  17. Bohn OL, Ruiz-Arguelles G, Navarro L, Saldivar J, Sanchez-Sosa S. Cutaneous Langerhans cell sarcoma: a case report and review of the literature. Int J Hematol 2007;85:116-20.

    Article  PubMed  CAS  Google Scholar 

  18. Ferringer T, Banks PM, Metcalf JS. Langerhans cell sarcoma. Am J Dermatopathol 2006;28:36-9.

    Article  PubMed  Google Scholar 

  19. Gaertner EM, Tsokos M, Derringer GA, Neuhauser TS, Arciero C, Andriko JA. Interdigitating dendritic cell sarcoma. A report of four cases and review of the literature. Am J Clin Pathol 2001;115:589-97.

    Article  PubMed  CAS  Google Scholar 

  20. Pillay K, Solomon R, Daubenton JD, Sinclair-Smith CC. Interdigitating dendritic cell sarcoma: a report of four paediatric cases and review of the literature. Histopathology 2004;44:283-91.

    Article  PubMed  CAS  Google Scholar 

  21. Favara BE, Feller AC, Pauli M, et al. Contemporary classification of histiocytic disorders. The WHO Committee On Histiocytic/Reticulum Cell Proliferations. Reclassification Working Group of the Histiocyte Society. Med Pediatr Oncol 1997;29:157-66.

    Article  PubMed  CAS  Google Scholar 

  22. Weitzman S, Jaffe R. Uncommon histiocytic disorders: the non-Langerhans cell histiocytoses. Pediatr Blood Cancer 2005;45:256-64.

    Article  PubMed  Google Scholar 

  23. Zelger BW, Sidoroff A, Orchard G, Cerio R. Non-Langerhans cell histiocytoses. A new unifying concept. Am J Dermatopathol 1996;18:490-504.

    Article  PubMed  CAS  Google Scholar 

  24. Sun W, Nordberg ML, Fowler MR. Histiocytic sarcoma involving the central nervous system: clinical, immunohistochemical, and molecular genetic studies of a case with review of the literature. Am J Surg Pathol 2003;27:258-65.

    Article  PubMed  Google Scholar 

  25. Chen W, Lau SK, Fong D, et al. High frequency of clonal immunoglobulin receptor gene rearrangements in sporadic histiocytic/dendritic cell sarcomas. Am J Surg Pathol 2009.

    Google Scholar 

  26. Feldman AL, Arber DA, Pittaluga S, et al. Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone. Blood 2008;111:5433-9.

    Article  PubMed  CAS  Google Scholar 

  27. Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity. Arch Pathol 1969;87:63-70.

    PubMed  CAS  Google Scholar 

  28. Paulli M, Rosso R, Kindl S, et al. Immunophenotypic characterization of the cell infiltrate in five cases of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Hum Pathol 1992;23:647-54.

    Article  PubMed  CAS  Google Scholar 

  29. Paulli M, Bergamaschi G, Tonon L, et al. Evidence for a polyclonal nature of the cell infiltrate in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Br J Haematol 1995;91:415-8.

    Article  PubMed  CAS  Google Scholar 

  30. Pulsoni A, Anghel G, Falcucci P, et al. Treatment of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): report of a case and literature review. Am J Hematol 2002;69:67-71.

    Article  PubMed  Google Scholar 

  31. Audouin J, Comperat E, Le Tourneau A, et al. Myeloid sarcoma: clinical and morphologic criteria useful for diagnosis. Int J Surg Pathol 2003;11:271-82.

    Article  PubMed  CAS  Google Scholar 

  32. Pileri SA, Ascani S, Cox MC, et al. Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia 2007;21:340-50.

    Article  PubMed  CAS  Google Scholar 

  33. Jones D, Dorfman DM, Barnhill RL, Granter SR. Leukemic vasculitis: a feature of leukemia cutis in some patients. Am J Clin Pathol 1997;107:637-42.

    PubMed  CAS  Google Scholar 

  34. Herling M, Jones D. CD4+/CD56+ hematodermic tumor: the features of an evolving entity and its relationship to dendritic cells. Am J Clin Pathol 2007;127:687-700.

    Article  PubMed  Google Scholar 

  35. Petrella T, Comeau MR, Maynadie M, et al. ‘Agranular CD4+ CD56+ hematodermic neoplasm’ (blastic NK-cell lymphoma) originates from a population of CD56+ precursor cells related to plasmacytoid monocytes. Am J Surg Pathol 2002;26:852-62.

    Article  PubMed  Google Scholar 

  36. Khoury JD, Medeiros LJ, Manning JT, Sulak LE, Bueso-Ramos C, Jones D. CD56(+) TdT(+) blastic natural killer cell tumor of the skin: a primitive systemic malignancy related to myelomonocytic leukemia. Cancer 2002;94:2401-8.

    Article  PubMed  CAS  Google Scholar 

  37. Chen WC, Jones D, Ho CL, et al. Cytogenetic anomalies in hyaline vascular Castleman disease: report of two cases with reappraisal of histogenesis. Cancer Genet Cytogenet 2006;164:110-7.

    Article  PubMed  CAS  Google Scholar 

  38. Chan JK, Fletcher CD, Nayler SJ, Cooper K. Follicular dendritic cell sarcoma. Clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized. Cancer 1997;79:294-313.

    Article  PubMed  CAS  Google Scholar 

  39. Hollowood K, Stamp G, Zouvani I, Fletcher CD. Extranodal follicular dendritic cell sarcoma of the gastrointestinal tract. Morphologic, immunohistochemical and ultrastructural analysis of two cases. Am J Clin Pathol 1995;103:90-7.

    PubMed  CAS  Google Scholar 

  40. Monda L, Warnke R, Rosai J. A primary lymph node malignancy with features suggestive of dendritic reticulum cell differentiation. A report of 4 cases. Am J Pathol 1986;122:562-72.

    PubMed  CAS  Google Scholar 

  41. Lee IJ, Kim SC, Kim HS, et al. Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma arising from Castleman's tumor. J Am Acad Dermatol 1999;40:294-7.

    Article  PubMed  CAS  Google Scholar 

  42. Grogg KL, Lae ME, Kurtin PJ, Macon WR. Clusterin expression distinguishes follicular dendritic cell tumors from other dendritic cell neoplasms: report of a novel follicular dendritic cell marker and clinicopathologic data on 12 additional follicular dendritic cell tumors and 6 additional interdigitating dendritic cell tumors. Am J Surg Pathol 2004;28:988-98.

    Article  PubMed  Google Scholar 

  43. Jones D, Amin M, Ordonez NG, Glassman AB, Hayes KJ, Medeiros LJ. Reticulum cell sarcoma of lymph node with mixed dendritic and fibroblastic features. Mod Pathol 2001;14:1059-67.

    Article  PubMed  CAS  Google Scholar 

  44. Sander B, Middel P, Gunawan B, et al. Follicular dendritic cell sarcoma of the spleen. Hum Pathol 2007;38:668-72.

    Article  PubMed  CAS  Google Scholar 

  45. Lin O, Frizzera G. Angiomyoid and follicular dendritic cell proliferative lesions in Castleman's disease of hyaline-vascular type: a study of 10 cases. Am J Surg Pathol 1997;21:1295-306.

    Article  PubMed  CAS  Google Scholar 

  46. Soriano AO, Thompson MA, Admirand JH, et al. Follicular dendritic cell sarcoma: a report of 14 cases and a review of the literature. Am J Hematol 2007;82:725-8.

    Article  PubMed  Google Scholar 

  47. Andriko JW, Kaldjian EP, Tsokos M, Abbondanzo SL, Jaffe ES. Reticulum cell neoplasms of lymph nodes: a clinicopathologic study of 11 cases with recognition of a new subtype derived from fibroblastic reticular cells. Am J Surg Pathol 1998;22:1048-58.

    Article  PubMed  CAS  Google Scholar 

  48. Martel M, Sarli D, Colecchia M, et al. Fibroblastic reticular cell tumor of the spleen: report of a case and review of the entity. Hum Pathol 2003;34:954-7.

    Article  PubMed  Google Scholar 

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Correspondence to Kedar V. Inamdar .

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Inamdar, K.V., Jones, D. (2010). Histiocytic and Dendritic Cell Neoplasms. In: Jones, D. (eds) Neoplastic Hematopathology. Contemporary Hematology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-384-8_26

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  • DOI: https://doi.org/10.1007/978-1-60761-384-8_26

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  • Publisher Name: Humana Press, Totowa, NJ

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