Skip to main content
SpringerLink
Log in

Classification of T-cell and NK-cell Malignancies

  • Chapter
  • First Online:
Neoplastic Hematopathology

Part of the book series: Contemporary Hematology ((CH))

  • 2341 Accesses

Abstract/Scope of Chapter

This chapter provides an overview of mature T-cell malignancies, including those presenting in lymph nodes (e.g., angioimmunoblastic T-cell lymphoma), extranodal sites (e.g., hepatosplenic T-cell lymphoma), and leukemias (e.g., Sézary syndrome). The role of the two prototypic mature T-cell oncogenes, ALK kinase in anaplastic large cell lymphoma and TCL1 in T-cell prolymphocytic leukemia, is discussed. A general model for T-cell tumor initiation involving canonical and aberrant signaling through the T-cell receptor is presented. The clinical presentation and morphologic range of NK-cell malignancies are also discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 299.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Baleydier F, Decouvelaere AV, Bergeron J, et al. T cell receptor genotyping and HOXA/TLX1 expression define three T lymphoblastic lymphoma subsets which might affect clinical outcome. Clin Cancer Res 2008;14:692-700.

    Article  PubMed  CAS  Google Scholar 

  2. Weng AP, Ferrando AA, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004;306:269-71.

    Article  PubMed  CAS  Google Scholar 

  3. Leich E, Haralambieva E, Zettl A, et al. Tissue microarray-based screening for chromosomal breakpoints affecting the T-cell receptor gene loci in mature T-cell lymphomas. J Pathol 2007;213:99-105.

    Article  PubMed  CAS  Google Scholar 

  4. Armitage J, Vose J, Weisenburger D. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol 2008;26:4124-30.

    Article  PubMed  Google Scholar 

  5. Abouyabis AN, Shenoy PJ, Lechowicz MJ, Flowers CR. Incidence and outcomes of the peripheral T-cell lymphoma subtypes in the United States. Leuk Lymphoma 2008;49:2099-107.

    Article  PubMed  Google Scholar 

  6. Stewart BW, Kleihues P Global burden of cancer. World Cancer Report. Lyon, France: IARC Press, 2003:12-9.

    Google Scholar 

  7. Jones D, Weissmann DJ, Kraus MD, Hasserjian RP, Shahsafaei A, Dorfman DM. Recurrences in nodal T-cell lymphoma. Changes in histologic appearance and immunophenotype over the course of disease. Am J Clin Pathol 2000;114:438-47.

    Article  PubMed  CAS  Google Scholar 

  8. Jones D, Jorgensen JL, Shahsafaei A, Dorfman DM. Characteristic proliferations of reticular and dendritic cells in angioimmunoblastic lymphoma. Am J Surg Pathol 1998;22:956-64.

    Article  PubMed  CAS  Google Scholar 

  9. Grogg KL, Attygalle AD, Macon WR, Remstein ED, Kurtin PJ, Dogan A. Expression of CXCL13, a chemokine highly upregulated in germinal center T-helper cells, distinguishes angioimmunoblastic T-cell lymphoma from peripheral T-cell lymphoma, unspecified. Mod Pathol 2006;19:1101-7.

    PubMed  CAS  Google Scholar 

  10. Dorfman DM, Brown JA, Shahsafaei A, Freeman GJ. Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma. Am J Surg Pathol 2006;30:802-10.

    Article  PubMed  Google Scholar 

  11. Ottaviani G, Bueso-Ramos CE, Seilstad K, Medeiros LJ, Manning JT, Jones D. The role of the perifollicular sinus in determining the complex immunoarchitecture of angioimmunoblastic T-cell lymphoma. Am J Surg Pathol 2004;28:1632-40.

    Article  PubMed  Google Scholar 

  12. Attygalle AD, Kyriakou C, Dupuis J, et al. Histologic evolution of angioimmunoblastic T-cell lymphoma in consecutive biopsies: clinical correlation and insights into natural history and disease progression. Am J Surg Pathol 2007;31:1077-88.

    Article  PubMed  Google Scholar 

  13. Balague O, Martinez A, Colomo L, et al. Epstein-Barr virus negative clonal plasma cell proliferations and lymphomas in peripheral T-cell lymphomas: a phenomenon with distinctive clinicopathologic features. Am J Surg Pathol 2007;31:1310-22.

    Article  PubMed  Google Scholar 

  14. Rudiger T, Ichinohasama R, Ott MM, et al. Peripheral T-cell lymphoma with distinct perifollicular growth pattern: a distinct subtype of T-cell lymphoma? Am J Surg Pathol 2000;24:117-22.

    Article  PubMed  CAS  Google Scholar 

  15. Rudiger T, Geissinger E, Muller-Hermelink HK. ‘Normal counterparts’ of nodal peripheral T-cell lymphoma. Hematol Oncol 2006;24:175-80.

    Article  PubMed  Google Scholar 

  16. Jiang L, Jones D, Medeiros LJ, Orduz YR, Bueso-Ramos CE. Peripheral T-cell lymphoma with a “follicular” pattern and the perifollicular sinus phenotype. Am J Clin Pathol 2005;123:448-55.

    Article  PubMed  Google Scholar 

  17. Medeiros LJ, Elenitoba-Johnson KS. Anaplastic large cell lymphoma. Am J Clin Pathol 2007;127:707-22.

    Article  PubMed  Google Scholar 

  18. D’Amore E, Menin A, Bonoldi E, et al. Anaplastic large cell lymphomas: a study of 75 pediatric patients. Pediatr Dev Pathol 2007;10(3):181-91.

    Article  PubMed  Google Scholar 

  19. Falini B, Pileri S, Zinzani PL, et al. ALK+ lymphoma: clinico-pathological findings and outcome. Blood 1999;93:2697-706.

    PubMed  CAS  Google Scholar 

  20. Kinney MC, Collins RD, Greer JP, Whitlock JA, Sioutos N, Kadin ME. A small-cell-predominant variant of primary Ki-1 (CD30)+ T-cell lymphoma. Am J Surg Pathol 1993;17:859-68.

    Article  PubMed  CAS  Google Scholar 

  21. ten Berge RL, Oudejans JJ, Ossenkoppele GJ, Meijer CJ. ALK-negative systemic anaplastic large cell lymphoma: differential diagnostic and prognostic aspects - a review. J Pathol 2003;200:4-15.

    Article  PubMed  Google Scholar 

  22. Zettl A, Ott G, Makulik A, et al. Chromosomal gains at 9q characterize enteropathy-type T-cell lymphoma. Am J Pathol 2002;161:1635-45.

    Article  PubMed  CAS  Google Scholar 

  23. Dogan A, Morice WG. Bone marrow histopathology in peripheral T-cell lymphomas. Br J Haematol 2004;127:140-54.

    Article  PubMed  Google Scholar 

  24. Massimino M, Gasparini M, Giardini R. Ki-1 (CD30) anaplastic large-cell lymphoma in children. Ann Oncol 1995;6:915-20.

    PubMed  CAS  Google Scholar 

  25. Vega F, Medeiros LJ, Bueso-Ramos C, et al. Hepatosplenic gamma/delta T-cell lymphoma in bone marrow. A sinusoidal neoplasm with blastic cytologic features. Am J Clin Pathol 2001;116:410-9.

    Article  PubMed  CAS  Google Scholar 

  26. Grewal JS, Smith LB, Winegarden JD 3rd, Krauss JC, Tworek JA, Schnitzer B. Highly aggressive ALK-positive anaplastic large cell lymphoma with a leukemic phase and multi-organ involvement: a report of three cases and a review of the literature. Ann Hematol 2007;86:499-508.

    Article  PubMed  Google Scholar 

  27. Osuji N, Beiske K, Randen U, et al. Characteristic appearances of the bone marrow in T-cell large granular lymphocyte leukaemia. Histopathology 2007;50:547-54.

    Article  PubMed  CAS  Google Scholar 

  28. Huh YO, Medeiros LJ, Ravandi F, Konoplev S, Jorgensen JL, Miranda RN. T-cell large granular lymphocyte leukemia associated with myelodysplastic syndrome: a clinicopathologic study of nine cases. Am J Clin Pathol 2009;131:347-56.

    Article  PubMed  CAS  Google Scholar 

  29. Wlodarski MW, Nearman Z, Jankowska A, et al. Phenotypic differences between healthy effector CTL and leukemic LGL cells support the notion of antigen-triggered clonal transformation in T-LGL leukemia. J Leukoc Biol 2008;83:589-601.

    Article  PubMed  CAS  Google Scholar 

  30. Lima M, Almeida J, Santos AH, et al. Immunophenotypic analysis of the TCR-Vbeta repertoire in 98 persistent expansions of CD3(+)/TCR-alphabeta(+) large granular lymphocytes: utility in assessing clonality and insights into the pathogenesis of the disease. Am J Pathol 2001;159:1861-8.

    Article  PubMed  CAS  Google Scholar 

  31. Morice WG, Kurtin PJ, Leibson PJ, Tefferi A, Hanson CA. Demonstration of aberrant T-cell and natural killer-cell antigen expression in all cases of granular lymphocytic leukaemia. Br J Haematol 2003;120:1026-36.

    Article  PubMed  CAS  Google Scholar 

  32. Airo P, Rossi G, Facchetti F, et al. Monoclonal expansion of large granular lymphocytes with a CD4+ CD8dim+/- phenotype associated with hairy cell leukemia. Haematologica 1995;80:146-9.

    PubMed  CAS  Google Scholar 

  33. Herling M, Khoury JD, Washington LT, Duvic M, Keating MJ, Jones D. A systematic approach to diagnosis of mature T-cell leukemias reveals heterogeneity among WHO categories. Blood 2004;104:328-35.

    Article  PubMed  CAS  Google Scholar 

  34. Klemke CD, Fritzsching B, Franz B, et al. Paucity of FOXP3+ cells in skin and peripheral blood distinguishes Sezary syndrome from other cutaneous T-cell lymphomas. Leukemia 2006;20:1123-9.

    Article  PubMed  CAS  Google Scholar 

  35. Matutes E, Keeling DM, Newland AC, et al. Sezary cell-like leukemia: a distinct type of mature T cell malignancy. Leukemia 1990;4:262-6.

    PubMed  CAS  Google Scholar 

  36. Mao X, McElwaine S. Functional copy number changes in Sezary syndrome: toward an integrated molecular cytogenetic map III. Cancer Genet Cytogenet 2008;185:86-94.

    Article  PubMed  CAS  Google Scholar 

  37. Karube K, Aoki R, Nomura Y, et al. Usefulness of flow cytometry for differential diagnosis of precursor and peripheral T-cell and NK-cell lymphomas: analysis of 490 cases. Pathol Int 2008;58:89-97.

    Article  PubMed  Google Scholar 

  38. Shimoyama M. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). Br J Haematol 1991;79:428-37.

    Article  PubMed  CAS  Google Scholar 

  39. Matutes E. Adult T-cell leukaemia/lymphoma. J Clin Pathol 2007;60:1373-7.

    Article  PubMed  CAS  Google Scholar 

  40. Tan BT, Seo K, Warnke RA, Arber DA. The frequency of immunoglobulin heavy chain gene and T-cell receptor gamma-chain gene rearrangements and Epstein-Barr virus in ALK+ and ALK- anaplastic large cell lymphoma and other peripheral T-cell lymphomas. J Mol Diagn 2008;10:502-12.

    Article  PubMed  Google Scholar 

  41. Schutzinger C, Esterbauer H, Hron G, et al. Prognostic value of T-cell receptor gamma rearrangement in peripheral blood or bone marrow of patients with peripheral T-cell lymphomas. Leuk Lymphoma 2008;49:237-46.

    Article  PubMed  Google Scholar 

  42. Feldman AL, Law M, Remstein ED, et al. Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas. Leukemia 2009;23(3):574-80.

    Article  PubMed  CAS  Google Scholar 

  43. Macon WR, Levy NB, Kurtin PJ, et al. Hepatosplenic alphabeta T-cell lymphomas: a report of 14 cases and comparison with hepatosplenic gammadelta T-cell lymphomas. Am J Surg Pathol 2001;25:285-96.

    Article  PubMed  CAS  Google Scholar 

  44. Bourgault-Rouxel AS, Loughran TP Jr, Zambello R, et al. Clinical spectrum of gammadelta+ T cell LGL leukemia: analysis of 20 cases. Leuk Res 2008;32:45-8.

    Article  PubMed  CAS  Google Scholar 

  45. Takaku T, Miyazawa K, Sashida G, et al. Hepatosplenic alphabeta T-cell lymphoma with myelodysplastic syndrome. Int J Hematol 2005;82:143-7.

    Article  PubMed  Google Scholar 

  46. Gaulier A, Jary-Bourguignat L, Serna R, Pulik M, Davi F, Raphael M. Occurrence of angioimmunoblastic T cell lymphoma in a patient with chronic myelomonocytic leukemia features. Leuk Lymphoma 2000;40:197-204.

    Article  PubMed  CAS  Google Scholar 

  47. Newrzela S, Cornils K, Li Z, et al. Resistance of mature T cells to oncogene transformation. Blood 2008;112:2278-86.

    Article  PubMed  CAS  Google Scholar 

  48. MacLeod RA, Nagel S, Scherr M, et al. Human leukemia and lymphoma cell lines as models and resources. Curr Med Chem 2008;15:339-59.

    Article  PubMed  CAS  Google Scholar 

  49. Amin HM, Lai R. Pathobiology of ALK+ anaplastic large-cell lymphoma. Blood 2007;110:2259-67.

    Article  PubMed  CAS  Google Scholar 

  50. Turner SD, Yeung D, Hadfield K, Cook SJ, Alexander DR. The NPM-ALK tyrosine kinase mimics TCR signalling pathways, inducing NFAT and AP-1 by RAS-dependent mechanisms. Cell Signal 2007;19:740-7.

    Article  PubMed  CAS  Google Scholar 

  51. Herling M, Patel KA, Teitell MA, et al. High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia. Blood 2008;111:328-37.

    Article  PubMed  CAS  Google Scholar 

  52. Feldman AL, Sun DX, Law ME, et al. Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomas. Leukemia 2008;22:1139-43.

    Article  PubMed  CAS  Google Scholar 

  53. Admirand J, Rassidakis G, Medeiros LJ, Jones D. CD3-independent activation of downstream effectors ZAP-70 and Syk in T-cell lymphomas. Lab Invest 2004;84:237A.

    Google Scholar 

  54. Zhang T, Barber A, Sentman CL. Chimeric NKG2D modified T cells inhibit systemic T-cell lymphoma growth in a manner involving multiple cytokines and cytotoxic pathways. Cancer Res 2007;67:11029-36.

    Article  PubMed  CAS  Google Scholar 

  55. Jones D, Fletcher CD, Pulford K, Shahsafaei A, Dorfman DM. The T-cell activation markers CD30 and OX40/CD134 are expressed in nonoverlapping subsets of peripheral T-cell lymphoma. Blood 1999;93:3487-93.

    PubMed  CAS  Google Scholar 

  56. Jones D, Dorfman DM. Phenotypic characterization of subsets of T cell lymphoma: towards a functional classification of T cell lymphoma. Leuk Lymphoma 2001;40:449-59.

    Article  PubMed  CAS  Google Scholar 

  57. Ballester B, Ramuz O, Gisselbrecht C, et al. Gene expression profiling identifies molecular subgroups among nodal peripheral T-cell lymphomas. Oncogene 2006;25:1560-70.

    Article  PubMed  CAS  Google Scholar 

  58. Martinez-Delgado B. Peripheral T-cell lymphoma gene expression profiles. Hematol Oncol 2006;24:113-9.

    Article  PubMed  CAS  Google Scholar 

  59. de Leval L, Rickman DS, Thielen C, et al. The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells. Blood 2007;109:4952-63.

    Article  PubMed  Google Scholar 

  60. Pitini V, Arrigo C, Altavilla G. Gene expression profiling does not identify molecular subgroup among nodal peripheral T-cell lymphomas. J Clin Oncol 2007;25:4851. author reply 4851-2.

    Article  PubMed  Google Scholar 

  61. Piccaluga PP, Agostinelli C, Califano A, et al. Gene expression analysis of angioimmunoblastic lymphoma indicates derivation from T follicular helper cells and vascular endothelial growth factor deregulation. Cancer Res 2007;67:10703-10.

    Article  PubMed  CAS  Google Scholar 

  62. Booken N, Gratchev A, Utikal J, et al. Sezary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3. Leukemia 2008;22:393-9.

    Article  PubMed  CAS  Google Scholar 

  63. Shah MV, Zhang R, Irby R, et al. Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes. Blood 2008;112:770-81.

    Article  PubMed  CAS  Google Scholar 

  64. Cuadros M, Dave SS, Jaffe ES, et al. Identification of a proliferation signature related to survival in nodal peripheral T-cell lymphomas. J Clin Oncol 2007;25:3321-9.

    Article  PubMed  Google Scholar 

  65. Agostinelli C, Piccaluga PP, Went P, et al. Peripheral T cell lymphoma, not otherwise specified: the stuff of genes, dreams and therapies. J Clin Pathol 2008;61:1160-7.

    Article  PubMed  CAS  Google Scholar 

  66. Miyazaki K, Yamaguchi M, Imai H, et al. Gene expression profiling of peripheral T-cell lymphoma including gammadelta T-cell lymphoma. Blood 2009;113:1071-4.

    Article  PubMed  CAS  Google Scholar 

  67. Martinez-Delgado B, Melendez B, Cuadros M, et al. Expression profiling of T-cell lymphomas differentiates peripheral and lymphoblastic lymphomas and defines survival related genes. Clin Cancer Res 2004;10:4971-82.

    Article  PubMed  CAS  Google Scholar 

  68. Rassidakis GZ, Jones D, Thomaides A, et al. Apoptotic rate in peripheral T-cell lymphomas. A study using a tissue microarray with validation on full tissue sections. Am J Clin Pathol 2002;118:328-34.

    Article  PubMed  Google Scholar 

  69. Martinez-Delgado B, Cuadros M, Honrado E, et al. Differential expression of NF-kappaB pathway genes among peripheral T-cell lymphomas. Leukemia 2005;19:2254-63.

    Article  PubMed  CAS  Google Scholar 

  70. Higgins JP, van de Rijn M, Jones CD, Zehnder JL, Warnke RA. Peripheral T-cell lymphoma complicated by a proliferation of large B cells. Am J Clin Pathol 2000;114:236-47.

    Article  PubMed  CAS  Google Scholar 

  71. Huang Q, Chang KL, Gaal KK, Weiss LM. An aggressive extranodal NK-cell lymphoma arising from indolent NK-cell lymphoproliferative disorder. Am J Surg Pathol 2005;29:1540-3.

    Article  PubMed  Google Scholar 

  72. Ng WK, Lee CY, Li AS, Cheung LK. Nodal presentation of nasal-type NK/T-cell lymphoma. Report of two cases with fine needle aspiration cytology findings. Acta Cytol 2003;47:1063-8.

    Article  PubMed  Google Scholar 

  73. Tao J, Shelat SG, Jaffe ES, Bagg A. Aggressive Epstein-Barr virus-associated, CD8+, CD30+, CD56+, surface CD3-, natural killer (NK)-like cytotoxic T-cell lymphoma. Am J Surg Pathol 2002;26:111-8.

    Article  PubMed  Google Scholar 

  74. Wu X, Li P, Zhao J, et al. A clinical study of 115 patients with extranodal natural killer/T-cell lymphoma, nasal type. Clin Oncol (R Coll Radiol) 2008;20:619-25.

    Article  CAS  Google Scholar 

  75. Schwartz EJ, Molina-Kirsch H, Zhao S, Marinelli RJ, Warnke RA, Natkunam Y. Immunohistochemical characterization of nasal-type extranodal NK/T-cell lymphoma using a tissue microarray: an analysis of 84 cases. Am J Clin Pathol 2008;130:343-51.

    Article  PubMed  Google Scholar 

  76. Sawada A, Sato E, Koyama M, et al. NK-cell repertoire is feasible for diagnosing Epstein-Barr virus-infected NK-cell lymphoproliferative disease and evaluating the treatment effect. Am J Hematol 2006;81:576-81.

    Article  PubMed  Google Scholar 

  77. Lehner T. Special regulatory T cell review: the resurgence of the concept of contrasuppression in immunoregulation. Immunology 2008;123:40-4.

    Article  PubMed  CAS  Google Scholar 

  78. Granucci F, Zanoni I, Ricciardi-Castagnoli P. Central role of dendritic cells in the regulation and deregulation of immune responses. Cell Mol Life Sci 2008;65:1683-97.

    Article  PubMed  CAS  Google Scholar 

  79. Boyton RJ, Altmann DM. Natural killer cells, killer immunoglobulin-like receptors and human leucocyte antigen class I in disease. Clin Exp Immunol 2007;149:1-8.

    Article  PubMed  CAS  Google Scholar 

  80. Ian MX, Lan SZ, Cheng ZF, Dan H, Qiong LH. Suppression of EBNA1 expression inhibits growth of EBV-positive NK/T cell lymphoma cells. Cancer Biol Ther 2008;7:1602-6.

    Article  PubMed  CAS  Google Scholar 

  81. Kim TM, Lee SY, Jeon YK, et al. Clinical heterogeneity of extranodal NK/T-cell lymphoma, nasal type: a national survey of the Korean Cancer Study Group. Ann Oncol 2008;19:1477-84.

    Article  PubMed  CAS  Google Scholar 

  82. Li YX, Fang H, Liu QF, et al. Clinical features and treatment outcome of nasal-type NK/T-cell lymphoma of Waldeyer ring. Blood 2008;112:3057-64.

    Article  PubMed  CAS  Google Scholar 

  83. Au WY, Weisenburger DD, Intragumtornchai T, et al. Clinical differences between nasal and extranasal NK/T-cell lymphoma: a study of 136 cases from the International Peripheral T-cell Lymphoma Project. Blood 2009;113(17):3931-7.

    Article  PubMed  CAS  Google Scholar 

  84. Na II, Kang HJ, Park YH, et al. Prognostic factors for classifying extranodal NK/T cell lymphoma, nasal type, as lymphoid neoplasia. Eur J Haematol 2007;79:1-7.

    Article  PubMed  Google Scholar 

  85. Suh C, Kang YK, Roh JL, et al. Prognostic value of tumor 18F-FDG uptake in patients with untreated extranodal natural killer/T-cell lymphomas of the head and neck. J Nucl Med 2008;49:1783-9.

    Article  PubMed  Google Scholar 

  86. Yong W, Zheng W, Zhu J, et al. L-Asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type. Ann Hematol 2009;88(7):647-52.

    Article  PubMed  CAS  Google Scholar 

  87. Lee J, Au WY, Park MJ, et al. Autologous hematopoietic stem cell transplantation in extranodal natural killer/T cell lymphoma: a multinational, multicenter, matched controlled study. Biol Blood Marrow Transplant 2008;14:1356-64.

    Article  PubMed  Google Scholar 

  88. Merlo A, Turrini R, Dolcetti R, Zanovello P, Amadori A, Rosato A. Adoptive cell therapy against EBV-related malignancies: a survey of clinical results. Expert Opin Biol Ther 2008;8:1265-94.

    Article  PubMed  CAS  Google Scholar 

  89. Suwiwat S, Pradutkanchana J, Ishida T, Mitarnun W. Quantitative analysis of cell-free Epstein-Barr virus DNA in the plasma of patients with peripheral T-cell and NK-cell lymphomas and peripheral T-cell proliferative diseases. J Clin Virol 2007;40:277-83.

    Article  PubMed  CAS  Google Scholar 

  90. Nakashima Y, Tagawa H, Suzuki R, et al. Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia: different genomic alteration patterns of aggressive NK-cell leukemia and extranodal Nk/T-cell lymphoma, nasal type. Genes Chromosomes Cancer 2005;44:247-55.

    Article  PubMed  CAS  Google Scholar 

  91. Kawamata N, Inagaki N, Mizumura S, et al. Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders. Eur J Haematol 2005;74:424-9.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hematopathology, M. D. Anderson Cancer Center, The University of Texas, Houston, TX, USA

    Dan Jones

Authors
  1. Dan Jones
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dan Jones .

Editor information

Editors and Affiliations

  1. M.D. Anderson Cancer Center, The University of Texas, Holcombe Blvd. 1515 , Houston, 77030, U.S.A.

    Dan Jones

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Humana Press, a part of Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Jones, D. (2010). Classification of T-cell and NK-cell Malignancies. In: Jones, D. (eds) Neoplastic Hematopathology. Contemporary Hematology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-384-8_22

Download citation

  • DOI: https://doi.org/10.1007/978-1-60761-384-8_22

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-383-1

  • Online ISBN: 978-1-60761-384-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation