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Marginal Zone Lymphomas

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Neoplastic Hematopathology

Part of the book series: Contemporary Hematology ((CH))

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Marginal zone lymphoma (MZL) encompasses a heterogeneous group of small B-cell lymphomas, characterized by a predominance of tumor cells with a phenotype, homing pattern, and occasionally the appearance of the nonneoplastic marginal zone B cells that surround germinal centers and populate the white pulp of the spleen. Covered in this chapter are extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), nodal marginal zone lymphoma (NMZL), and splenic B-cell marginal zone lymphoma (SMZL). Although the different subtypes of MZL share histologic and immunophenotypic features, they have divergent etiologies, molecular genetics, and clinical presentations. The pathogeneses of NMZL and SMZL are not yet clearly understood. The relationship of SMZL to hairy cell leukemia (HCL) and HCL-variant (HCL-v) is also discussed.

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Authors and Affiliations

  1. Department of Hematopathology, M. D. Anderson Cancer Center, The University of Texas, Houston, TX, USA

    Rachel L. Sargent

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  1. Rachel L. Sargent
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Correspondence to Rachel L. Sargent .

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Editors and Affiliations

  1. M.D. Anderson Cancer Center, The University of Texas, Holcombe Blvd. 1515 , Houston, 77030, U.S.A.

    Dan Jones

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© 2010 Humana Press, a part of Springer Science+Business Media, LLC

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Sargent, R.L. (2010). Marginal Zone Lymphomas. In: Jones, D. (eds) Neoplastic Hematopathology. Contemporary Hematology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-384-8_15

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  • DOI: https://doi.org/10.1007/978-1-60761-384-8_15

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-383-1

  • Online ISBN: 978-1-60761-384-8

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