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Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

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Neoplastic Hematopathology

Part of the book series: Contemporary Hematology ((CH))

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Abstract/Scope of Chapter

This chapter covers chronic lymphocytic leukemia (CLL) and its variants as well as its lymph node counterpart, small lymphocytic lymphoma (SLL). The role of well-established and more experimental immunophenotypic and molecular biomarkers in predicting outcome and need for treatment in CLL/SLL is summarized.

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References

  1. Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 2008;111(12):5446-56.

    Article  PubMed  CAS  Google Scholar 

  2. Frater JL, McCarron KF, Hammel JP, et al. Typical and atypical chronic lymphocytic leukemia differ clinically and immunophenotypically. Am J Clin Pathol 2001;116(5):655-64.

    Article  PubMed  CAS  Google Scholar 

  3. Bennett JM, Catovsky D, Daniel MT, et al. Proposals for the classification of chronic (mature) B and T lymphoid leukaemias. French-American-British (FAB) Cooperative Group. J Clin Pathol 1989;42(6):567-84.

    Article  PubMed  CAS  Google Scholar 

  4. Schwarz J, Mikulenkova D, Cermakova M, et al. Prognostic relevance of the FAB morphological criteria in chronic lymphocytic leukemia: correlations with IgVH gene mutational status and other prognostic markers. Neoplasma 2006;53(3):219-25.

    PubMed  CAS  Google Scholar 

  5. Nola M, Pavletic SZ, Weisenburger DD, et al. Prognostic factors influencing survival in patients with B-cell small lymphocytic lymphoma. Am J Hematol 2004;77(1):31-5.

    Article  PubMed  Google Scholar 

  6. Dohner H, Stilgenbauer S, Dohner K, Bentz M, Lichter P. Chromosome aberrations in B-cell chronic lymphocytic leukemia: reassessment based on molecular cytogenetic analysis. J Mol Med 1999;77(2):266-81.

    Article  PubMed  CAS  Google Scholar 

  7. Muller-Hermelink HK, Montserrat E, Catovsky D, Campo E, Harris NL, Stein H. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC, 2008.

    Google Scholar 

  8. Ripolles L, Ortega M, Ortuno F, et al. Genetic abnormalities and clinical outcome in chronic lymphocytic leukemia. Cancer Genet Cytogenet 2006;171(1):57-64.

    Article  PubMed  CAS  Google Scholar 

  9. Sargent R, Jones D, Abruzzo LV, et al. Customized oligonucleotide array-based comparative genomic hybridization as a clinical assay for genomic profiling of chronic lymphocytic leukemia. J Mol Diagn 2009;11(1):25-34.

    Article  PubMed  CAS  Google Scholar 

  10. Shaffer AL, Rosenwald A, Staudt LM. Lymphoid malignancies: the dark side of B-cell differentiation. Nat Rev 2002;2(12):920-32.

    Article  CAS  Google Scholar 

  11. Fais F, Ghiotto F, Hashimoto S, et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998;102(8):1515-25.

    Article  PubMed  CAS  Google Scholar 

  12. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999;94(6):1848-54.

    PubMed  CAS  Google Scholar 

  13. Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999;94(6):1840-7.

    PubMed  CAS  Google Scholar 

  14. Herling M, Patel KA, Hsi ED, et al. TCL1 in B-cell tumors retains its normal b-cell pattern of regulation and is a marker of differentiation stage. Am J Surg Pathol 2007;31(7):1123-9.

    Article  PubMed  Google Scholar 

  15. Rosenwald A, Alizadeh AA, Widhopf G, et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 2001;194(11):1639-47.

    Article  PubMed  CAS  Google Scholar 

  16. Crespo M, Bosch F, Villamor N, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003;348(18):1764-75.

    Article  PubMed  CAS  Google Scholar 

  17. Rassenti LZ, Huynh L, Toy TL, et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 2004;351(9):893-901.

    Article  PubMed  CAS  Google Scholar 

  18. Herling M, Patel KA, Khalili J, et al. TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state. Leukemia 2006;20(2):280-5.

    Article  PubMed  CAS  Google Scholar 

  19. Rawstron AC, Villamor N, Ritgen M, et al. International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia. Leukemia 2007;21(5):956-64.

    PubMed  CAS  Google Scholar 

  20. Hamblin TJ. Richter’s syndrome - the downside of fludarabine? Leuk Res 2005;29(10):1103-4.

    Article  PubMed  Google Scholar 

  21. Rossi D, Cerri M, Capello D, et al. Biological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndrome. Br J Haematol 2008.

    Google Scholar 

  22. Thornton PD, Bellas C, Santon A, et al. Richter’s transformation of chronic lymphocytic leukemia. The possible role of fludarabine and the Epstein-Barr virus in its pathogenesis. Leuk Res 2005;29(4):389-95.

    Article  PubMed  CAS  Google Scholar 

  23. Ansell SM, Li CY, Lloyd RV, Phyliky RL. Epstein-Barr virus infection in Richter’s transformation. Am J Hematol 1999;60(2):99-104.

    Article  PubMed  CAS  Google Scholar 

  24. Keating MJ, O’Brien S, Lerner S, et al. Long-term follow-up of patients with chronic lymphocytic leukemia (CLL) receiving fludarabine regimens as initial therapy. Blood 1998;92(4):1165-71.

    PubMed  CAS  Google Scholar 

  25. Timar B, Fulop Z, Csernus B, et al. Relationship between the mutational status of VH genes and pathogenesis of diffuse large B-cell lymphoma in Richter’s syndrome. Leukemia 2004;18(2):326-30.

    Article  PubMed  CAS  Google Scholar 

  26. Stilgenbauer S, Dohner H. Molecular genetics and its clinical relevance. Hematol Oncol Clin North Am 2004;18(4):827-48. viii.

    Article  PubMed  Google Scholar 

  27. Thorselius M, Krober A, Murray F, et al. Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status. Blood 2006;107(7):2889-94.

    Article  PubMed  CAS  Google Scholar 

  28. Rassenti LZ, Jain S, Keating MJ, et al. Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia. Blood 2008;112(5):1923-30.

    Article  PubMed  CAS  Google Scholar 

  29. Ibrahim S, Keating M, Do KA, et al. CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia. Blood 2001;98(1):181-6.

    Article  PubMed  CAS  Google Scholar 

  30. Van Bockstaele F, Verhasselt B, Philippe J. Prognostic markers in chronic lymphocytic leukemia: a comprehensive review. Blood Rev 2009;23(1):25-47.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Hematopathology, M. D. Anderson Cancer Center, The University of Texas, Houston, TX, USA

    Ellen Schlette

Authors
  1. Ellen Schlette
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Corresponding author

Correspondence to Ellen Schlette .

Editor information

Editors and Affiliations

  1. M.D. Anderson Cancer Center, The University of Texas, Holcombe Blvd. 1515 , Houston, 77030, U.S.A.

    Dan Jones

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© 2010 Humana Press, a part of Springer Science+Business Media, LLC

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Schlette, E. (2010). Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma. In: Jones, D. (eds) Neoplastic Hematopathology. Contemporary Hematology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-384-8_14

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  • DOI: https://doi.org/10.1007/978-1-60761-384-8_14

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-383-1

  • Online ISBN: 978-1-60761-384-8

  • eBook Packages: MedicineMedicine (R0)

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