Abstract/Scope of Chapter
The lymph node and other secondary lymphoid tissues, such as the tonsil/Waldeyer’s ring and Peyer’s patches, are the sites in the immune system, where B cells encounter antigen and expand to produce effector and memory B cells and plasma cells, with the assistance of T cells. B-cell expansion and maturation then occurs mainly in the germinal center and T-cell expansion and activation occurs both in the germinal center and the interfollicular or paracortical regions. Reactive lymphadenitis has many causes, with some histologic patterns that may resemble lymphoma. Depending on the inciting cause, one or several lymph node compartments may be expanded with distinctive follicular, paracortical, sinusoidal or medullary, and mixed patterns. For example, expansion of the follicles with prominent germinal centers is due to factors that promote B-cell expansion, whereas progressive transformation of germinal centers and follicular lysis represent follicular expansions associated with dissolution and termination of the germinal center reaction.
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Miranda, R.N. (2010). Lymph Node Biology and Lymphadenitis. In: Jones, D. (eds) Neoplastic Hematopathology. Contemporary Hematology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-384-8_12
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DOI: https://doi.org/10.1007/978-1-60761-384-8_12
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