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Functional Tissue Reconstruction with the Use of Biologic Scaffolds

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Stem Cell Therapy for Diabetes

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Biologic scaffold materials derived from the extracellular matrix (ECM) of intact mammalian tissues are recognized as possessing constructive remodeling properties and have been used successfully in a variety of tissue engineering and regenerative medicine applications in both preclinical studies and clinical practice. This chapter provides an overview of the composition and structure of selected ECM scaffold materials, the effects of manufacturing methods upon the structural properties and resulting mechanical behavior of the scaffold materials, and the in-vivo degradation and remodeling of ECM scaffolds. Finally, the potential application of ECM scaffold materials to regeneration of endocrine tissues is discussed.

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Authors and Affiliations

  1. Departments of Surgery and Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA

    Stephen F. Badylak, Jennifer B. Ogilvie & Thomas W. Gilbert

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  1. Stephen F. Badylak
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  2. Jennifer B. Ogilvie
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  3. Thomas W. Gilbert
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Correspondence to Stephen F. Badylak .

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  1. Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel

    Shimon Efrat

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Badylak, S.F., Ogilvie, J.B., Gilbert, T.W. (2010). Functional Tissue Reconstruction with the Use of Biologic Scaffolds. In: Efrat, S. (eds) Stem Cell Therapy for Diabetes. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-60761-366-4_11

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