Abstract
ApoE mimetic peptide possesses the putative receptor binding domain 141–150 (LRKLRKRLLR) of apoE covalently linked to the class A amphipathic helical peptide 18A. It dramatically reduces plasma cholesterol in dyslipidemic mouse and rabbit models. Recycling of apoE mimetic peptide increases the duration of preβ-HDL formation leading to extended anti-inflammatory and atheroprotective properties.
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Datta, G., M. Chaddha, D.W.Garber, B.H.Chung, E.M.Tytler, N. Dashti, W.A.Bradley, S.H.Gianturco, and G.M.Anantharamaiah. 2000. The receptor binding domain of apolipoprotein E, linked to a model class A amphipathic helix, enhances internalization and degradation of LDL by fibroblasts. Biochemistry 39: 213–220
Garber, D.W., S.Handattu, I. Aslan, G.Datta, M. Chaddha, and G.M.Anantharamaiah. 2003. Effect of an arginine-rich helical peptide on plasma cholesterol in dyslipidemic mice. Atherosclerosis 168: 229–237
Gupta, H., C.R. White, S. Handattu, D.W. Garber, G. Datta, M. Chaddha, L. Dai, S.H. Gianturco, W.A. Bradley, and G.M. Anantharamaiah. 2005. Apolipoprotein E mimetic peptide dramatically lowers plasma cholesterol and restores endothelial function in Watanabe Heritable Hyperlipidemic rabbits. Circulation 111: 3112–3118
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Datta, G. et al. (2010). ApoE Mimetic Peptide Reduces Plasma Lipid Hydroperoxide Content with a Concomitant Increase in HDL Paraoxonase Activity. In: Reddy, S. (eds) Paraoxonases in Inflammation, Infection, and Toxicology. Advances in Experimental Medicine and Biology, vol 660. Humana Press. https://doi.org/10.1007/978-1-60761-350-3_1
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DOI: https://doi.org/10.1007/978-1-60761-350-3_1
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