Abstract
Stevens–Johnson syndrome and toxic epidermal necrolysis are variants of a single disease because of their manifestations and pathomechanisms. Stevens–Johnson syndrome/toxic epidermal necrolysis is a severe condition within the spectrum of diseases, including erythema multiforme major, toxic epidermal necrolysis, and Stevens–Johnson syndrome, and it is characterized by extensive epidermal death and widespread blisters and erosive lesions. Two challenging cases of toxic and epidermal necrolysis and several case study questions of the Stevens–Johnson syndrome/toxic epidermal necrolysis disease spectrum are discussed.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Parrillo SJ. Stevens-Johnson syndrome and toxic epidermal necrolysis. Curr Allergy Asthma Rep. 2007;7(4):243–7.
Hillebrand-Haverkort ME, Budding AE, bij de Vaate LA, van Agtmael MA. Mycoplasma pneumoniae infection with incomplete Stevens-Johnson syndrome. Lancet Infect Dis. 2008;8(10):586–7.
Mockenhaupt M, Messenheimer J, Tennis P, et al. Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics. Neurology. 2005;64(7):1134–8.
Halevy S, Ghislain PD, Mockenhaupt M, Fagot JP, Bouwes Bavinck JN, Sidoroff A, et al. Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel. J Am Acad Dermatol. 2008;58(1):25–32.
Roujeau JC. The spectrum of Stevens Johnson syndrome and toxic epidermal necrolysis: a clinical classification. J Invest Dermatol. 1994; 102(1): 28S–30S.
Bastuji-Garin S, Fouchard N, Bertocchi M, et al. SCORTEN: a severity-of-illness score for toxic epidermal necrolysis. J Invest Dermatol. 2000;115(2):149–53.
Gambichler T, Al-Muhammadi R, Boms S. Immunologically mediated photodermatoses: diagnosis and treatment. Am J Clin Dermatol. 2009;10(3):169–80.
Redondo P, Vicente J, España A, Subira ML, De Felipe I, Quintanilla E. Photo-induced toxic epidermal necrolysis caused by clobazam. Br J Dermatol. 1996; 135(6):999–1002.
Paul C, Wolkenstein P, Adle H, Wechsler J, Garchon HJ, Revuz J, Roujeau JC. Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis. Br J Dermatol. 1996;134(4):710–4.
Prins C, Kerdel FA, Padilla RS, Hunziker T, Chimenti S, Viard I, Mauri DN, Flynn K, Trent J, Margolis DJ, Saurat JH, French LE; TEN-IVIG Study Group. Toxic epidermal necrolysis-intravenous immunoglobulin. Treatment of toxic epidermal necrolysis with high-dose intravenous immunoglobulins: multicenter retrospective analysis of 48 consecutive cases. Arch Dermatol. 2003;139(1):26–32.
Tristani-Firouzi P, Petersen MJ, Saffle JR, Morris SE, Zone JJ. Treatment of toxic epidermal necrolysis with intravenous immunoglobulin in children. J Am Acad Dermatol. 2002; 47(4):548–52.
Bachot N, Revuz J, Roujeau JC. Intravenous immunoglobulin treatment for Stevens-Johnson syndrome and toxic epidermal necrolysis: a prospective noncomparative study showing no benefit on mortality or progression. Arch Dermatol. 2003;139(1):33–6.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Yoshida, S. (2010). Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis. In: Mahmoudi, M. (eds) Challenging Cases in Allergic and Immunologic Diseases of the Skin. Springer, New York, NY. https://doi.org/10.1007/978-1-60761-296-4_6
Download citation
DOI: https://doi.org/10.1007/978-1-60761-296-4_6
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-60761-295-7
Online ISBN: 978-1-60761-296-4
eBook Packages: MedicineMedicine (R0)