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Mammalian Brain Development pp 171–192Cite as

In Vivo Imaging of Brain Development: Technologies, Models, Applications, and Impact on Understanding the Etiology of Mental Retardation

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Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

Development of the mammalian brain proceeds in a precisely controlled sequence of cell divisions, migration, differentiation, and synaptogenesis. It is a process of precise dynamic assembly, and time lapse in vivo imaging of these processes is fundamental for the multidisciplinary endeavor to merge and understand the morphological, physiological, and regulatory processes of neurogenesis.

Modern optical and non-optical imaging technologies enable us to achieve 5-dimensional (5D) imaging of neurogenesis: 3-dimensional (3D) images of neuronal structures, collected over time (4D) in the living tissue or specimen, with simultaneous spectral information and data indicating specific structures, cellular phenotypes, functions, or genes expression patterns (5D). These imaging technologies make it possible to simultaneously monitor structure and function in vivo and merge morphological and physiological perspectives on brain development.

Modern in vivo imaging technologies combined with advances in molecular biology definitely have the potential to unravel basic mechanisms of neurogenesis. Further advances will enable these technologies to elucidate the pathogenesis of developmental neurological disorders and eventually make critical steps of neurogenesis clinically detectable and therapeutically approachable.

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  1. Section of Neurosurgery, The University of Chicago Medical Center, University of Chicago, 5841 South Maryland Avenue, Chicago, IL, 60637, USA

    Vicko Gluncic MD, PhD

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    Gluncic, V. (2009). In Vivo Imaging of Brain Development: Technologies, Models, Applications, and Impact on Understanding the Etiology of Mental Retardation. In: Janigro, D. (eds) Mammalian Brain Development. Contemporary Neuroscience. Humana Press. https://doi.org/10.1007/978-1-60761-287-2_9

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