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The Na + /Ca 2+ Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia

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New Strategies in Stroke Intervention

Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

The Na+/Ca2+ exchanger (NCX) belongs to the superfamily of Ca2+/cation antiporter (CaCA) membrane proteins comprising the following members: (1) the NCX family, which exchanges three Na+ ions for one Ca2+ ion (Reeves and Hale, 1984; Fujioka et al., 2000; Kang and Hilgemann, 2004); (2) the Na+/Ca2+ exchanger K+-dependent family (NCKX), which exchanges four Na+ for one Ca2+ plus one K+ ion [1, 2]; (3) the bacterial family which probably promotes Ca2+/H+ exchange (YRBG) [3]; (4) the nonbacterial Ca2+/H+ exchange family (CAX), which is also the Ca2+ exchanger of yeast vacuoles [4]; and (5) the Ca2+/cation exchanger family (CCX), which contains the partially characterized molecule previously called Na+/Ca2+–Li+ exchanger (NCLX or NCKX6).

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  1. Division Pharmacology, Department of Neuroscience, School of Medicine, “Federico II” University of Naples, Naples, Italy

    Lucio Annunziato, Pasquale Molinaro, Agnese Secondo, Anna Pannaccione, Antonella Scorziello, Giuseppe Pignataro, Ornella Cuomo, Rossana Sirabella, Francesca Boscia, Alessandra Spinali & Gianfranco Di Renzo

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    Lucio Annunziato

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Annunziato, L. et al. (2009). The Na + /Ca 2+ Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia . In: Annunziato, L. (eds) New Strategies in Stroke Intervention. Contemporary Neuroscience. Humana Press. https://doi.org/10.1007/978-1-60761-280-3_5

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