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Hematopathology pp 39–78Cite as

Classical and Molecular Cytogenetic Analysis of Hematolymphoid Disorders

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Part of the book series: Molecular and Translational Medicine ((MOLEMED))

Abstract

Non-random chromosomal abnormalities are a common feature of many hematolymphoid disorders and are a key component of their pathogenesis. As such, routine chromosome analysis is critical in the laboratory workup of most known or suspected myelodysplastic/myeloproliferative disorders, leukemias, and lymphomas. Such studies can provide (1) diagnostic confirmation; (2) information useful for classification, staging, and prognostication; (3) information to guide appropriate choice of therapy; and (4) evidence of remission or relapse. In lymph node evaluation, cytogenetics can differentiate a reactive process from a malignant condition.

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Authors and Affiliations

  1. Beaumont Laboratory, Department of Anatomic Pathology, Beaumont Hospitals, 3601 W. Thirteen Mile Rd, Royal Oak, MI, 48073, USA

    Mark A. Micale

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  1. Mark A. Micale
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Correspondence to Mark A. Micale .

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  1. , Department of Clinical Pathology, William Beaumont Hospital, West 13 Mile Road 3601, Royal Oak, 48073-6769, USA

    Domnita Crisan

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© 2011 Humana Press

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Micale, M.A. (2011). Classical and Molecular Cytogenetic Analysis of Hematolymphoid Disorders. In: Crisan, D. (eds) Hematopathology. Molecular and Translational Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-262-9_2

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  • DOI: https://doi.org/10.1007/978-1-60761-262-9_2

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  • Publisher Name: Humana Press, Totowa, NJ

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