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Micro-RNAs in Hematologic Malignancies

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Hematopathology

Part of the book series: Molecular and Translational Medicine ((MOLEMED))

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Abstract

Micro-RNAs (miRNAs) are small noncoding RNAs with gene regulatory functions. Abnormal expression of miRNAs distinguishes normal from tumoral tissues in both solid and hematological malignancies. These aberrations parallel abnormal expression of miRNA target genes, which ultimately are responsible for the development of the malignant phenotype. Intriguingly, miRNAs expression levels are variable during normal hematopoiesis, revealing that their up/downregulation is required during the physiologic differentiation of the hematopoietic multipotent precursor. Therefore, variations in miRNA levels mirror abnormal expression of their target genes and are involved in the development of lymphomas and leukemias. This chapter will describe how miRNAs affect normal hematopoiesis and contribute to the genesis of hematological malignancies, and how they affect the prognosis, and harbor therapeutic implications for patients affected by lymphomas and leukemias.

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Authors and Affiliations

  1. Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, OH, 43210, USA

    Muller Fabbri

  2. Departments of Experimental Therapeutics and Cancer Genetics, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA

    George A. Calin

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Correspondence to Muller Fabbri .

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  1. , Department of Clinical Pathology, William Beaumont Hospital, West 13 Mile Road 3601, Royal Oak, 48073-6769, USA

    Domnita Crisan

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Fabbri, M., Calin, G.A. (2011). Micro-RNAs in Hematologic Malignancies. In: Crisan, D. (eds) Hematopathology. Molecular and Translational Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-262-9_10

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  • DOI: https://doi.org/10.1007/978-1-60761-262-9_10

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