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Management of Prostate Cancer pp 1–11Cite as

Epidemiology and Risk Factors

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Part of the book series: Current Clinical Urology ((CCU))

Abstract

Prostate cancer (PCa) is the second leading cause of cancer-related death in men in the United States. The incidence and mortality of PCa vary widely among different countries in the world, with an overall steady rise in incidence and fall in mortality. However, the disparity between reported incidence and mortality rates since the initiation of screening with PSA is strongly suggestive of an overtreatment of the disease. The growing evidence from genetic studies points to the multiple gene loci rather than specific susceptibility genes to play a major role in inheritable familial predisposition to PCa. Apart from family history, age, and ethnicity, exposure to different environmental factors such as diet, different chemicals, and infections contributes significantly to the risk of development of PCa.

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Authors and Affiliations

  1. Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue/Q10-1, Cleveland, OH, 44195, USA

    Ranko Miocinovic

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  1. Ranko Miocinovic
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Correspondence to Ranko Miocinovic .

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Editors and Affiliations

  1. , Glickman Urological and Kidney, Cleveland Clinic, 9500 Euclid Ave, Cleveland, 44195, Ohio, USA

    Eric A. Klein

  2. Cleveland Clinic, Cleveland Clinic Lerner College of Medic, Department of Regional Urology, at Case Western Reserve, Cleveland, 44195, Ohio, USA

    J. Stephen Jones

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Miocinovic, R. (2012). Epidemiology and Risk Factors. In: Klein, E., Jones, J. (eds) Management of Prostate Cancer. Current Clinical Urology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-259-9_1

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  • DOI: https://doi.org/10.1007/978-1-60761-259-9_1

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  • Publisher Name: Humana Press, Totowa, NJ

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