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Structural and Electrophysiological Remodeling of the Failing Heart

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Renin Angiotensin System and Cardiovascular Disease

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

The influence of the renin angiotensin aldosterone system on the structural and electrophysiological remodeling of the failing heart is discussed including changes in cell communication, impulse propagation, and the generation of cardiac arrhythmias. Particular attention was given to the harmful effects of angiotensin II and the beneficial influence of ACE inhibitors, AT1 receptor blockers, and angiotensin [1–7] on cardiac function and cardiac remodeling. Finally, the role of the renin angiotensin aldosterone system on the regulation of cell volume in the failing heart was discussed and evidence was provided that the intracrine RAS plays an important role in the regulation of cell volume. Pathophysiological implications of the change in cell volume are discussed.

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  1. School of Medicine, Medical Sciences Campus, UPR, San Juan, PR, USA

    Walmor C. DeMello MD, PhD

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Correspondence to Walmor C. DeMello MD, PhD .

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Editors and Affiliations

  1. Department of Pharmacology, University of Puerto Rico, San Juan, 00936, U.S.A.

    Walmor C. DeMello

  2. Ochsner Clinic Foundation, Jefferson Highway 1514 , New Orleans, 70121, U.S.A.

    Edward D. Frohlich

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DeMello, W.C. (2009). Structural and Electrophysiological Remodeling of the Failing Heart. In: DeMello, W., Frohlich, E. (eds) Renin Angiotensin System and Cardiovascular Disease. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-60761-186-8_7

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  • DOI: https://doi.org/10.1007/978-1-60761-186-8_7

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