Summary
Chronic diarrhea is defined as passage of loose stools for more than 4 weeks. In most instances the cause of chronic diarrhea can be discovered and treated effectively. A few less common causes also play a role: laxative abuse, small bowel bacterial overgrowth, and even bile acid malabsorption. Rarer syndromes account for a much smaller percentage of chronic diarrheas but may be more difficult to identify and treat. In a small number of patients, a cause for chronic diarrhea cannot be found and they are said to have chronic idiopathic secretory diarrhea, a fairly homogeneous disorder that can be sporadic or epidemic. This disorder can be diagnosed after excluding other causes of chronic diarrhea; it is associated with moderate weight loss and gradually subsides after 1.5–3 years. A sensible approach to the patient with chronic diarrhea of unexplained cause is based on a comprehensive history, focusing on the stool characteristics (watery, bloody, fatty), the occurrence of weight loss, aggravating and mitigating factors (with special emphasis on the diet); on a thorough physical examination and on the careful use of selected laboratory investigations such as complete blood count, comprehensive metabolic panel, thyroid tests, and of course stool tests such as bacterial cultures and extensive search for parasites; electrolytes, pH, occult blood test, leukocytes (or lactoferrin/calprotectin) and fat assessment. Subsequent analysis will depend on the findings from history, physical exam, and stool analysis and may or may not include more aggressive investigations such as CT enterography, small bowel follow-through radiograms, and videocapsule enteroscopy. Additional tests may have to be occasionally utilized, including plasma peptides (chromogranin, gastrin, calcitonin, VIP, somatostatin) and urine chemistry tests (5-HIAA, metanephrines, histamine).
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Fine KD, Schiller LR. AGA technical review on the evaluation and management of chronic diarrhea. Gastroenterology 1999; 116:1464–1486.
Chang JY, Locke GR 3rd, Schleck CO, Zinsmeister AR, Talley NJ. Risk factors for chronic diarrhea in the community in the absence of irritable bowel syndrome. Neurogastroenterol Motil 2009; 21:1060–1087. Epub 2009 May 21.
Hungin APS, Chang L, Locke GR, Dennis EH, Barghout V. Irritable bowel syndrome in the United States: prevalence, symptom patterns and impact. Aliment Pharmacol Ther 2005; 21:1365–1375.
Afzalpurkar RG, Schiller LR, Little KH, Santangelo WC, Fordtran JS. The self-limited nature of chronic idiopathic diarrhea. N Engl J Med 1992; 327:1849–1852.
Wenzl HH, Fine KD, Schiller LR, Fordtran JS. Determinants of decreased fecal consistency in patients with diarrhea. Gastroenterology 1995; 108:1729–1738.
Tucker DM, Sandstead HH, Logan GM jr, Klevay LM, Mahalko J, Johnson LK, Inman L, Inglett GE. Dietary fiber and personality factors as determinants of stool output. Gastroenterology 1981; 81:879–883.
Pawlowski SW, Warren CA, Guerrant R. Diagnosis and treatment of acute or persistent diarrhea. Gastroenterology 2009; 136:1874–1886.
Eherer AJ, Fordtran JS. Fecal osmotic gap and pH in experimental diarrhea of various causes. Gastroenterology 1992; 103:545–51.
Fine KD, Ogunji F. A new method of quantitative fecal fat microscopy and its correlation with chemically measured fecal fat output. Am J Clin Path 2000; 113:528–534.
Schiller LR, Rivera LM, Santangelo WC, Little KH, Fordtran JS. Diagnostic value of fasting plasma peptide concentrations in patients with chronic diarrhea. Dig Dis Sci 1994; 39:2216–2222.
Fernandez-Banares F, Esteve M, Salas A, et al. Systematic evaluation of the causes of chronic watery diarrhea with functional characteristics. Am J Gastroenterol 2007; 102:2520–2528.
Centers for Disease Control. Chronic diarrhea associated with raw milk consumption—Minnesota. MMWR Morb Mortal Wkly Rep 1984; 33:521–522, 527–528.
Osterholm MT, MacDonald KL, White KE, et al. An outbreak of a newly recognized chronic diarrhea syndrome associated with raw milk consumption. JAMA 1986; 256:484–490.
Martin DL, Hoberman LJ. A point source outbreak of chronic diarrhea in Texas: no known exposure to raw milk. JAMA 1986; 256:469.
Parsonnet J, Trock SC, Bopp CA, et al. Chronic diarrhea associated with drinking untreated water. Ann Intern Med 1989; 110:985–991.
Mintz ED, Weber JT, Guris D, et al. An outbreak of Brainerd diarrhea among travelers to the Galapagos Islands. J Infect Dis 1998; 177:1041–1045.
Kimura AC, Mead P, Walsh B, et al. A large outbreak of Brainerd diarrhea associated with a restaurant in the Red River Valley, Texas. Clin Infect Dis 2006; 43:55–61.
Vugia DJ, Abbott S, Mintz ED, et al. A restaurant-associated outbreak of Brainerd diarrhea in California. Clin Infect Dis 2006; 43:62–64.
Schiller LR. Review article: anti-diarrhoeal pharmacology and therapeutics. Aliment Pharmacol Ther 1995; 9:87–106.
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Schiller, L.R. (2010). Chronic Idiopathic Diarrhea. In: Guandalini, S., Vaziri, H. (eds) Diarrhea. Clinical Gastroenterology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-183-7_18
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DOI: https://doi.org/10.1007/978-1-60761-183-7_18
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