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Centrosomes in Checkpoint Responses

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Checkpoint Controls and Targets in Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Centrosomes consist of a pair of barrel-shaped centrioles, surrounded by a pericentriolar matrix. Their best characterized function is to organize both interphase microtubule arrays and the mitotic spindle, which mediates the strictly bipolar separation of chromosomes during cell division. In addition, centrosomes have come into focus as part of a network that integrates cell cycle arrest and repair signals in response to genotoxic stress. Recent evidence suggests that centrosomes are involved in both, regulation of the G2/M transition in response to DNA damage and induction of cell death via centrosome amplification and mitotic catastrophe as a backup mechanism for the elimination of cells that evade DNA damage checkpoints operating earlier during the cell cycle. While other aspects of the G2/M checkpoint are described elsewhere, this chapter will focus on the emerging role of centrosomes as regulators and effectors of DNA damage at mitotic entry.

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  1. Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center and Department of Internal Medicine V, University of Heidelberg, 69120, Heidelberg, Germany

    Alwin Krämer

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  1. M.D. Anderson Cancer Center, University of Texas, Holcombe Blvd. 1515, Houston, 77030, U.S.A.

    Zahid H. Siddik

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Krämer, A. (2010). Centrosomes in Checkpoint Responses. In: Siddik, Z. (eds) Checkpoint Controls and Targets in Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-60761-178-3_4

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