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Heart Failure of Aging: Clinical Considerations

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Book cover Heart Failure

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Although the physiological decline occurring during aging is much more subtle than that observed in young people and adults with cardiac disease, heart failure (HF) is a disease of the elderly. This may be related to a significant loss of cardiac myocytes occurring through apoptosis; this loss may be secondary to mitochondrial dysfunction, probably caused by chronic exposure to ROS, which will result in damaged mtDNA (mutations and deletions) and mitochondrial membranes. In this chapter, we will discuss clinical aspects of HF in the elderly and define their etiology, pathophysiology, clinical presentation, diagnosis and common approaches to therapeutic interventions, including pharmacotherapy, and device and replacement therapies.

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Authors and Affiliations

  1. The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA

    José Marín-García MD (Director)

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  1. José Marín-García MD
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Correspondence to José Marín-García MD .

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Marín-García, J. (2010). Heart Failure of Aging: Clinical Considerations. In: Heart Failure. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-147-9_17

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  • DOI: https://doi.org/10.1007/978-1-60761-147-9_17

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-146-2

  • Online ISBN: 978-1-60761-147-9

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