Genetic Risk Factors in Chronic Tinnitus

Keypoints

  1. 1.

    Individual susceptibility to chronic tinnitus is shaped by the interplay of genetic and environmental factors.

     
  2. 2.

    Whereas many environmental risks including noise trauma and medication side effects are already well understood, heritable risks remain to be specified.

     
  3. 3.

    Pilot biometric studies in twins have produced heritability estimates of up to 0.39 in subgroups of affected patients but are still burdened with confounders.

     
  4. 4.

    The current review addresses the quest for molecular genetic biomarkers of tinnitus and the candidate genes examined so far.

     
  5. 5.

    Of these, genes encoding neurotrophic factors BDNF and GDNF give promising results that warrant further study.

     
  6. 6.

    Public attitude toward advances in genetic testing for tinnitus is as yet unexplored and deserves consideration in future research.

     

Keywords

Tinnitus Association study Familial clustering Genetic risk Heritability Mutation screening Tinnitus susceptibility 

Abbreviations

BDNF

brain-derived neurotrophic factor

CNTF

ciliary neurotrophic factor

GDNF

glial cell-derived neurotrophic factor

HTTLPR

serotonin transporter gene length polymorphic region

HTR1A

serotonin receptor 1A

HTR3A

serotonin receptor 3A

HUNT-II

North-Trøndelag Health Study II (1995–1997)

PRNP

Prion protein

SLC6A4 (5-HTT)

solute carrier 6A4 (serotonin transporter)

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of PsychiatryUniversity of RegensburgRegensburgGermany

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