Genetic Risk Factors in Chronic Tinnitus
- Philipp G. SandAffiliated withDepartment of Psychiatry, University of Regensburg Email author
Individual susceptibility to chronic tinnitus is shaped by the interplay of genetic and environmental factors.
Whereas many environmental risks including noise trauma and medication side effects are already well understood, heritable risks remain to be specified.
Pilot biometric studies in twins have produced heritability estimates of up to 0.39 in subgroups of affected patients but are still burdened with confounders.
The current review addresses the quest for molecular genetic biomarkers of tinnitus and the candidate genes examined so far.
Of these, genes encoding neurotrophic factors BDNF and GDNF give promising results that warrant further study.
Public attitude toward advances in genetic testing for tinnitus is as yet unexplored and deserves consideration in future research.
KeywordsTinnitus Association study Familial clustering Genetic risk Heritability Mutation screening Tinnitus susceptibility
- Genetic Risk Factors in Chronic Tinnitus
- Book Title
- Textbook of Tinnitus
- Book Part
- Part I
- pp 47-50
- Print ISBN
- Online ISBN
- Springer New York
- Copyright Holder
- Springer Science+Business Media, LLC
- Additional Links
- Association study
- Familial clustering
- Genetic risk
- Mutation screening
- Tinnitus susceptibility
- Industry Sectors
- eBook Packages
- Editor Affiliations
- 1. School of Behavioral and Brain Sciences, The University of Texas at Dallas
- 2. Department of Psychiatry Psychotherapy and Psychosomatics, University of Regensburg
- 3. BRAI2N/TRI Tinnitus Clinic and Department of Neurosurgery, University Hospital Antwerp
- 4. Department of Otorhinolaryngology, University of Regensburg
- Philipp G. Sand (1)
- Author Affiliations
- 1. Department of Psychiatry, University of Regensburg, Universitaetsstr. 84, 93053, Regensburg, Germany
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