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The Pharmacologist

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References

  1. Eggermont JJ (2007) Pathophysiology of tinnitus. Prog Brain Res 166:19–35.

    Article  PubMed  CAS  Google Scholar 

  2. Eggermont JJ (2008) Role of auditory cortex in noise- and drug-induced tinnitus. Am J Audiol 17:S162–9.

    Article  PubMed  Google Scholar 

  3. Kaltenbach JA and DA Godfrey (2008) Dorsal cochlear nucleus hyperactivity and tinnitus: are they related? Am J Audiol 17:S148–61.

    Article  PubMed  Google Scholar 

  4. Bauer CA, JG Turner, DM Caspary et al (2008) Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma. J Neurosci Res 86:2564–78.

    Article  PubMed  CAS  Google Scholar 

  5. Lanting CP, E De Kleine, H Bartels et al (2008) Functional imaging of unilateral tinnitus using fMRI. Acta Otolaryngol 128:415–21.

    Article  PubMed  CAS  Google Scholar 

  6. Reyes SA, RJ Salvi, RF Burkard et al (2002) Brain imaging of the effects of lidocaine on tinnitus. Hear Res 171:43–50.

    Article  PubMed  CAS  Google Scholar 

  7. Melcher JR, IS Sigalovsky, JJ Guinan, Jr. et al (2000) Lateralized tinnitus studied with functional magnetic resonance imaging: abnormal inferior colliculus activation. J Neurophysiol 83:1058–72.

    PubMed  CAS  Google Scholar 

  8. Schlee W, T Hartmann, B Langguth et al (2009) Abnormal resting-state cortical coupling in chronic tinnitus. BMC Neurosci 10:11.

    Article  PubMed  Google Scholar 

  9. Smits M, S Kovacs, D de Ridder et al (2007) Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus. Neuroradiology 49:669–79.

    Article  PubMed  Google Scholar 

  10. Lambert RC, T Bessaih and N Leresche (2006) Modulation of neuronal T-type calcium channels. CNS Neurol Disord Drug Targets 5:611–27.

    Article  PubMed  CAS  Google Scholar 

  11. Surmeier DJ, J Ding, M Day et al (2007) D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons. Trends Neurosci 30:228–35.

    Article  PubMed  CAS  Google Scholar 

  12. Wonnacott S, J Barik, J Dickinson et al (2006) Nicotinic receptors modulate transmitter cross talk in the CNS: nicotinic modulation of transmitters. J Mol Neurosci 30:137–40.

    Article  PubMed  CAS  Google Scholar 

  13. Slassi A, M Isaac, L Edwards et al (2005) Recent advances in non-competitive mGlu5 receptor antagonists and their potential therapeutic applications. Curr Top Med Chem 5:897–911.

    Article  PubMed  CAS  Google Scholar 

  14. Blank T, I Nijholt, MJ Kye et al (2004) Small conductance Ca2 + -activated K + channels as targets of CNS drug development. Curr Drug Targets CNS Neurol Disord 3:161–7.

    Article  PubMed  CAS  Google Scholar 

  15. Muroi Y and B Chanda (2009) Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol 133:1–15.

    Article  PubMed  CAS  Google Scholar 

  16. Duckert LG and TS Rees (1983) Treatment of tinnitus with intravenous lidocaine: a double-blind randomized trial. Otolaryngol Head Neck Surg 91:550–5.

    PubMed  CAS  Google Scholar 

  17. Israel JM, JS Connelly, ST McTigue et al (1982) Lidocaine in the treatment of tinnitus aurium. A double-blind study. Arch Otolaryngol 108:471–3.

    Article  PubMed  CAS  Google Scholar 

  18. Kalcioglu MT, T Bayindir, T Erdem et al (2005) Objective evaluation of the effects of intravenous lidocaine on tinnitus. Hear Res 199:81–8.

    Article  PubMed  Google Scholar 

  19. Lenarz T (1986) Treatment of tinnitus with lidocaine and tocainide. Scand Audiol Suppl 26:49–51.

    PubMed  CAS  Google Scholar 

  20. Melding PS, RJ Goodey and PR Thorne (1978) The use of intravenous lignocaine in the diagnosis and treatment of tinnitus. J Laryngol Otol 92:115–21.

    Article  PubMed  CAS  Google Scholar 

  21. Merchant SN and N Merchant (1985) Intravenous lignocaine in tinnitus. J Postgrad Med 31:80–2.

    PubMed  CAS  Google Scholar 

  22. Trellakis S, J Lautermann and G Lehnerdt (2007) Lidocaine: neurobiological targets and effects on the auditory system. Prog Brain Res 166:303–22.

    Article  PubMed  CAS  Google Scholar 

  23. Darlington CL and PF Smith (2007) Drug treatments for tinnitus. Prog Brain Res 166:249–62.

    Article  PubMed  CAS  Google Scholar 

  24. Patterson MB and BJ Balough (2006) Review of pharmacological therapy for tinnitus. Int Tinnitus J 12:149–59.

    PubMed  CAS  Google Scholar 

  25. Møller AR (2007) Tinnitus: presence and future. Prog Brain Res 166:3–16.

    Article  PubMed  CAS  Google Scholar 

  26. Levine RA (2006) Typewriter tinnitus: a carbamazepine-responsive syndrome related to auditory nerve vascular compression. ORL J Otorhinolaryngol Relat Spec 68:43–6; discussion 6–7.

    Article  PubMed  CAS  Google Scholar 

  27. Mardini MK (1987) Ear-clicking “tinnitus” responding to carbamazepine. N Engl J Med 317:1542.

    PubMed  CAS  Google Scholar 

  28. Tyler R, C Coelho, P Tao et al (2008) Identifying tinnitus subgroups with cluster analysis. Am J Audiol 17:S176–84.

    Article  PubMed  Google Scholar 

  29. Eggermont JJ (2005) Tinnitus: neurobiological substrates. Drug Discov Today 10:1283–90.

    Article  PubMed  Google Scholar 

  30. Enna SJ and M Williams (2009) Challenges in the search for drugs to treat central nervous system disorders. J Pharmacol Exp Ther. 329: 404–11.

    Article  PubMed  CAS  Google Scholar 

  31. Spedding M, T Jay, J Costa e Silva et al (2005) A pathophysiological paradigm for the therapy of psychiatric disease. Nat Rev Drug Discov 4:467–76.

    Article  PubMed  CAS  Google Scholar 

  32. Henry TR (2003) The history of valproate in clinical neuroscience. Psychopharmacol Bull 37 Suppl 2:5–16.

    PubMed  Google Scholar 

  33. Carpenter WT and JI Koenig (2008) The evolution of drug development in schizophrenia: past issues and future opportunities. Neuropsychopharmacology 33:2061–79.

    Article  PubMed  CAS  Google Scholar 

  34. Johannessen Landmark C (2008) Antiepileptic drugs in non-epilepsy disorders: relations between mechanisms of action and clinical efficacy. CNS Drugs 22:27–47.

    Article  PubMed  Google Scholar 

  35. Bauer CA (2003) Animal models of tinnitus. Otolaryngol Clin North Am 36:267–85.

    Article  PubMed  Google Scholar 

  36. Jastreboff PJ and JF Brennan (1994) Evaluating the loudness of phantom auditory perception (tinnitus) in rats. Audiology 33:202–17.

    Article  PubMed  CAS  Google Scholar 

  37. Turner JG (2007) Behavioral measures of tinnitus in laboratory animals. Prog Brain Res 166:147–56.

    Article  PubMed  Google Scholar 

  38. De Ridder D, H Fransen, O Francois et al (2006) Amygdalohippocampal involvement in tinnitus and auditory memory. Acta Otolaryngol Suppl 556:50–3.

    Article  PubMed  Google Scholar 

  39. Jastreboff PJ and MM Jastreboff (2006) Tinnitus retraining therapy: a different view on tinnitus. ORL J Otorhinolaryngol Relat Spec 68:23–9; discussion 9–30.

    Article  PubMed  Google Scholar 

  40. Bauer CA (2004) Mechanisms of tinnitus generation. Curr Opin Otolaryngol Head Neck Surg 12:413–7.

    Article  PubMed  Google Scholar 

  41. Hurko O and JL Ryan (2005) Translational research in central nervous system drug discovery. NeuroRx 2:671–82.

    Article  PubMed  Google Scholar 

  42. Frankenburg FR and RJ Baldessarini (2008) Neurosyphilis, malaria, and the discovery of antipsychotic agents. Harv Rev Psychiatry 16:299–307.

    Article  PubMed  Google Scholar 

  43. Langguth B, R Goodey, A Azevedo et al (2007) Consensus for tinnitus patient assessment and treatment outcome measurement: Tinnitus Research Initiative meeting, Regensburg, July 2006. Prog Brain Res 166:525–36.

    Article  PubMed  CAS  Google Scholar 

  44. Vio MM and RH Holme (2005) Hearing loss and tinnitus: 250 million people and a US$10 billion potential market. Drug Discov Today 10:1263–5.

    Article  PubMed  Google Scholar 

  45. Plazas PV, J Savino, S Kracun et al (2007) Inhibition of the alpha9alpha10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-D-aspartate receptors. Eur J Pharmacol 566:11–9.

    Article  PubMed  CAS  Google Scholar 

  46. Brocco M, A Dekeyne, C Mannoury la Cour et al (2008) Cellular and behavioural profile of the novel, selective neurokinin1 receptor antagonist, vestipitant: a comparison to other agents. Eur Neuropsychopharmacol 18:729–50.

    Article  PubMed  CAS  Google Scholar 

  47. Eggermont JJ and H Komiya (2000) Moderate noise trauma in juvenile cats results in profound cortical topographic map changes in adulthood. Hear Res 142:89-101.

    Article  PubMed  CAS  Google Scholar 

  48. Norena AJ and JJ Eggermont (2003) Changes in spontaneous neural activity immediately after an acoustic trauma: implications for neural correlates of tinnitus. Hear Res 183:137–53.

    Article  PubMed  CAS  Google Scholar 

  49. Norena AJ, M Tomita and JJ Eggermont (2003) Neural changes in cat auditory cortex after a transient pure-tone trauma. J Neurophysiol 90:2387–401.

    Article  PubMed  Google Scholar 

  50. Muhlnickel W, T Elbert, E Taub et al (1998) Reorganization of auditory cortex in tinnitus. Proc Natl Acad Sci USA 95:10340–3.

    Article  PubMed  CAS  Google Scholar 

  51. Norena AJ and JJ Eggermont (2005) Enriched acoustic environment after noise trauma reduces hearing loss and prevents cortical map reorganization. J Neurosci 25:699–705.

    Article  PubMed  CAS  Google Scholar 

  52. Norena AJ and JJ Eggermont (2006) Enriched acoustic environment after noise trauma abolishes neural signs of tinnitus. Neuroreport 17:559–63.

    Article  PubMed  Google Scholar 

  53. Stark H and H Scheich (1997) Dopaminergic and serotonergic neurotransmission systems are differentially involved in auditory cortex learning: a long-term microdialysis study of metabolites. J Neurochem 68:691–7.

    Article  PubMed  CAS  Google Scholar 

  54. Bao S, VT Chan and MM Merzenich (2001) Cortical remodelling induced by activity of ventral tegmental dopamine neurons. Nature 412:79–83.

    Article  PubMed  CAS  Google Scholar 

  55. Kilgard MP and MM Merzenich (1998) Cortical map reorganization enabled by nucleus basalis activity. Science 279:1714–8.

    Article  PubMed  CAS  Google Scholar 

  56. Gritti I, L Mainville and BE Jones (1993) Codistribution of GABA- with acetylcholine-synthesizing neurons in the basal forebrain of the rat. J Comp Neurol 329:438–57.

    Article  PubMed  CAS  Google Scholar 

  57. Gritti I, L Mainville, M Mancia et al (1997) GABAergic and other noncholinergic basal forebrain neurons, together with cholinergic neurons, project to the mesocortex and isocortex in the rat. J Comp Neurol 383:163–77.

    Article  PubMed  CAS  Google Scholar 

  58. Seki S and JJ Eggermont (2003) Changes in spontaneous firing rate and neural synchrony in cat primary auditory cortex after localized tone-induced hearing loss. Hear Res 180:28–38.

    Article  PubMed  Google Scholar 

  59. Lobarinas E, W Dalby-Brown, D Stolzberg et al (2009) Effects of the BK Agonists BMS-204352 and the Enantiomeric Compound (“R-Enantiomer”) on Transient, Salicylate Induced Tinnitus in Rats. Association for Research in Otolarygol Baltimore, MD.

    Google Scholar 

  60. Nardi A and SP Olesen (2008) BK channel modulators: a comprehensive overview. Curr Med Chem 15:1126–46.

    Article  PubMed  CAS  Google Scholar 

  61. Korsgaard MP, BP Hartz, WD Brown et al (2005) Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels. J Pharmacol Exp Ther 314:282–92.

    Article  PubMed  CAS  Google Scholar 

  62. de Lafuente V and R Romo (2005) Neuronal correlates of subjective sensory experience. Nat Neurosci 8:1698–703.

    Article  PubMed  Google Scholar 

  63. de Lafuente V and R Romo (2006) Neural correlate of subjective sensory experience gradually builds up across cortical areas. Proc Natl Acad Sci U S A 103:14266–71.

    Article  PubMed  Google Scholar 

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Correspondence to Ana Belén Elgoyhen .

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Elgoyhen, A.B., Rothlin, C.V. (2011). The Pharmacologist. In: Møller, A.R., Langguth, B., De Ridder, D., Kleinjung, T. (eds) Textbook of Tinnitus. Springer, New York, NY. https://doi.org/10.1007/978-1-60761-145-5_30

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