Behavioral Animal Models of Tinnitus, Pharmacology, and Treatment
Tinnitus research on humans is difficult, primarily because the pathophysiology of tinnitus is still not well understood.
A number of animal models have been developed in order to study conditions that may lead to tinnitus and evaluate treatments for efficacy and safety before being used in human trials.
- 3.Current tinnitus animal models fall into five general subtypes:
Startle reflex models
- 4.Animal models have evaluated tinnitus induced primarily by:
High doses of sodium salicylate
High doses of quinine
High-level noise exposure
- 5.A number of tinnitus treatments that target specific mechanisms have been proposed and tested in animal models. These include:
Calcium channel antagonists
Potassium channel modulators
Transcranial magnetic stimulation
Tinnitus animal models provide important guidance in the development of new drug therapies.
KeywordsAnimal models Drug therapy Startle reflex Tinnitus
Gap prepulse inhibition of the acoustic startle
Narrow band noise
Noise burst prepulse inhibition of the acoustic startle
Repeated transcranial magnetic stimulation
Schedule induced polydipsia avoidance conditioning
- 2.Jastreboff PJ (1994) Instrumentation and tinnitus: A neurophysiological approach. Hear Instrum 45:7–11.Google Scholar
- 3.Hazell J and JB Sheldrake. The Tinnitus and Hyperacusis Centre [website]. [cited 2006 15 April]; Available from: http://www.tinnitus.org.
- 10.Turner JG, (2006) Gap detection as a high throughput, objective behavioral screen for tinnitus, in The future treatment of tinnitus: First Tinnitus Research Initiative meeting 27–29 July 2006. 2006: Regensburg, Salzstadel, Germany.Google Scholar