Behavioral Animal Models of Tinnitus, Pharmacology, and Treatment
Tinnitus research on humans is difficult, primarily because the pathophysiology of tinnitus is still not well understood.
A number of animal models have been developed in order to study conditions that may lead to tinnitus and evaluate treatments for efficacy and safety before being used in human trials.
- 3.Current tinnitus animal models fall into five general subtypes:
Startle reflex models
- 4.Animal models have evaluated tinnitus induced primarily by:
High doses of sodium salicylate
High doses of quinine
High-level noise exposure
- 5.A number of tinnitus treatments that target specific mechanisms have been proposed and tested in animal models. These include:
Calcium channel antagonists
Potassium channel modulators
Transcranial magnetic stimulation
Tinnitus animal models provide important guidance in the development of new drug therapies.
KeywordsAnimal models Drug therapy Startle reflex Tinnitus
Gap prepulse inhibition of the acoustic startle
Narrow band noise
Noise burst prepulse inhibition of the acoustic startle
Repeated transcranial magnetic stimulation
Schedule induced polydipsia avoidance conditioning
The authors would like to thank Daniel Stolzberg for his important contributions in developing the GPIAS animal model of tinnitus.
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