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Biology of Stem Cells and the Molecular Basis of the Stem State pp 177–216Cite as

The Stem State: Stemness as a State in the Cell’s Life Cycle

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

The stem state is characterized by pluripotency that entails a genome-wide gene expression. New cells may be recruited into the stem cell pool, following selfrenewal divisions of cells existing in the stem state. The stem cell niche enforces the process of self-renewal. An alternative path leading to the stem state is dedifferentiation of cells, at later stages of the differentiation cascade. Thus, cellular plasticity entailing dedifferentiation and transdifferentiation, governed by reprogramming through epigenetic modulations, form the basis of stemness.

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  1. Department of Molecular Cell Biology, Weizmann Institute of Science, 76 100, Rehovot, Israel

    Dov Zipori

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Correspondence to Dov Zipori .

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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Zipori, D. (2009). The Stem State: Stemness as a State in the Cell’s Life Cycle. In: Biology of Stem Cells and the Molecular Basis of the Stem State. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-60761-130-1_6

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