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Immunomodulatory Potential of Conjugated Linolenic Acid

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Dietary Components and Immune Function

Part of the book series: Nutrition and Health ((NH))

Key Points

Conjugated linoleic acid (CLA), isomers of linoleic acid (C18:2) have many biological effects, including potential immunomodulatory potential. CLA is an unrecognized nutrient that significantly protects lymphoidal and nonlymphoidal tissues from lymphoid events during immune stimulation. This protection is through the regulation of lipid eicosanoid mediators while nonlymphoidal tissues prevent their negative feedback on the immune response. With lipid mediator modulation there is enhanced immunity, improved efficiency of feed use, changes in body composition, and decrease in diseases with immune response. With regard to the immune system, it is not clear whether individual isomers of CLA could act similarly or differently. In this chapter, we are trying to uncover most of the fundamental findings to explore the effects of CLA in relation to immunomodulation.

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Author information

Authors and Affiliations

  1. Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Jaipur, India

    Saji Menon

  2. Bio-organic Chemistry Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA

    Shalini Jain

  3. Department of Biotechnology, School of Technology and Science, Lovely Professional University, Phagwara, Punjab, India

    Ravinder Nagpal

  4. Dairy Microbiology Division, National Dairy Research Institute, Karnal, Haryana, India

    Manoj Kumar

  5. Animal Biochemistry Division, National Dairy Research Institute, Karnal, Haryana, India

    Dheeraj Mohania

  6. School of Studies in Biochemistry, Jiwaji University, Gwalior, Madhya Pradesh, India

    Dhananjay Yadav

  7. NEmergency Unit, S. Giuseppe Hosital, Milano, Italy

    Fracesco Marotta

  8. Department of Biotechnology, College of Advanced Studies, Datia, Madhya Pradesh, India

    Mukesh Yadav

  9. Diabetes Branch, Clinical Research Center, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA

    Hariom Yadav

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  1. Saji Menon
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  2. Shalini Jain
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Correspondence to Hariom Yadav .

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Editors and Affiliations

  1. Health Sciences Center, Department of Health Promotion Sciences, University of Arizona, 1295 N. Martin Ave. 1295, Tucson, 85724-5155, USA

    Ronald Ross Watson

  2. Mel & Enid Zuckerman College of, Public Health, University of Arizona, Tucson, 85724-5163, USA

    Sherma Zibadi

  3. Dept. Nutrition & Dietetics, King's College, Stamford St. 150, London, SE1 9NH, United Kingdom

    Victor R. Preedy

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Menon, S. et al. (2010). Immunomodulatory Potential of Conjugated Linolenic Acid. In: Watson, R., Zibadi, S., Preedy, V. (eds) Dietary Components and Immune Function. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-061-8_12

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  • DOI: https://doi.org/10.1007/978-1-60761-061-8_12

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