Abstract
Shelterin, the telomere-secific protein complex, is essential for genome stability and cell viability. Shelterin accumulates at telomeres and transforms chromosome ends into specialized structures that evade recognition by the DNA damage signaling and repair machineries and are maintained through consecutive cell divisions. Shelterin accomplishes these tasks through its ability to remodel the telomeric DNA into a protected structure and to locally inhibit the activation of the DNA damage response. Furthermore, shelterin plays an essential role in controlling telomere length homeostasis by suppressing excessive nuclease activity at the chromosome terminus and by regulating telomerase. The capacities of the telomere-binding proteins to prevent genome instability and to influence telomere length make shelterin an essential factor in both normal cell growth and tumorigenesis.
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Dimitrova, N. (2009). Telomere-Binding Proteins in Humans. In: Hiyama, K. (eds) Telomeres and Telomerase in Cancer. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-60327-879-9_2
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