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CTLA-4 Blockade for Prostate Cancer Treatment

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Drug Management of Prostate Cancer

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Abstract

The immune system has demonstrated the ability to participate in cancer surveillance, but its role in promoting anticancer activity has only begun to be harnessed. Advances over the last 10 years have made the possibility of immunotherapy for the treatment of cancer a more realistic possibility. Prostate cancer is an ideal target for immunotherapy given its relatively slow growth rate and the time required to generate immune responses. This chapter will discuss an antibody to cytotoxic T lymphocyte antigen-4 (CTLA-4), which can dampen the restraints on T-cell activity to incite a T cell response to tumor, resulting in immune-mediated tumor regression, and the experience with this mechanism in treating advanced prostate cancer.

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Authors and Affiliations

  1. Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA, USA

    Andrea L. Harzstark

Authors
  1. Andrea L. Harzstark
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  2. Lawrence Fong
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Corresponding author

Correspondence to Andrea L. Harzstark .

Editor information

Editors and Affiliations

  1. Medical Oncology Branch, NIH National Cancer Institute, Rockville Pike 9000, Bethesda, 20892, Maryland, USA

    William D. Figg

  2. Medical Oncology Branch, NIH National Cancer Institute, Rockville Pike 9000, Bethesda, 20892, Maryland, USA

    Cindy H. Chau

  3. School of Medicine, Dept. Urology, University of California, San Francisco, Divisadero Street 1600, San Francisco, 94115, California, USA

    Eric J. Small

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Harzstark, A.L., Fong, L. (2010). CTLA-4 Blockade for Prostate Cancer Treatment. In: Figg, W., Chau, C., Small, E. (eds) Drug Management of Prostate Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-60327-829-4_30

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  • DOI: https://doi.org/10.1007/978-1-60327-829-4_30

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-60327-831-7

  • Online ISBN: 978-1-60327-829-4

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