Antifungal Resistance: Aspergillus

  • P. H. Chandrasekar
  • Elias K. Manavathu
Part of the Infectious Disease book series (ID)

Despite the availability of potent antifungal agents, systemic fungal infections continue to cause signifi cant morbidity and mortality. While candida-related deaths have declined since the late 1980s, those due to aspergillosis remain high. Fifty to ninety percent of patients with invasive aspergillosis (IA) die despite treatment (1–3). Susceptible hosts, particularly cancer patients and transplant recipients, are profoundly immunocompromised with neutropenia and/or impaired monocyte/macrophage dysfunction; there is universal agreement that the outcome of IA is largely dictated by the host immune status (4–6). Regardless of the antifungal drug(s) employed, the poor outcome or failure of antifungal therapy is generally attributed to compromised host defenses and in most cases, not considered to be due to drug resistant fungi. Also, failure of antifungal drugs may be due to inappropriate dose, fungistatic activity, high protein binding, poor absorption/ distribution and metabolism or drug interactions. Until recently, drug resistance in aspergillus was not adequately examined.


Invasive Aspergillosis Antimicrob Agent Aspergillus Fumigatus Antifungal Drug Liposomal Amphotericin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • P. H. Chandrasekar
    • 1
  • Elias K. Manavathu
    • 1
  1. 1.Department of Internal Medicine, Wayne State University School of MedicineHarper University HospitalDetroitUSA

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