Neuroblastoma is a malignant neoplasm of neural crest lineage, most often arising in the adrenal medulla, paraganglia, or sympathetic chain. Cutaneous neuroblastoma usually represents metastasis from a visceral primary. However, rare cutaneous neuroblastoma may develop de novo without an identifiable visceral tumor, possibly from heterotopic neural crest cells. Neuroblastoma represents the most primitive form in a family of neoplasms, which includes ganglioneuroma at the opposite, mature end of the spectrum.
Cutaneous neuroblastic and ganglionic tumors Definition Classification Histogenesis Diagnostic features Differential diagnosis neuroblastoma Ganglioneuroma Ganglion cell choristoma
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