Cutaneous Neuroblastic and Ganglion Cell Proliferations

  • Zsolt ArgenyiEmail author
  • Chris H. Jokinen
Part of the Current Clinical Pathology book series (CCPATH)


Neuroblastoma is a malignant neoplasm of ­neural crest lineage, most often arising in the adrenal medulla, paraganglia, or sympathetic chain. Cutaneous neuroblastoma usually represents metastasis from a visceral primary. However, rare cutaneous neuroblastoma may develop de novo without an identifiable visceral tumor, possibly from heterotopic neural crest cells. Neuroblastoma represents the most primitive form in a family of neoplasms, which includes ganglioneuroma at the opposite, mature end of the spectrum.


Cutaneous neuroblastic and ganglionic tumors Definition Classification Histogenesis Diagnostic features Differential diagnosis neuroblastoma Ganglioneuroma Ganglion cell choristoma 

Additional Reading

  1. Furmanczyk PS, Hughes SR, Walsh JS, Bass J, McFarlane JR, Argenyi ZB. Cutaneous ganglioneuroma associated with overlying hyperkeratotic epidermal changes: a report of 2 cases. Am J Dermatopathol. 2008;30:600–3.CrossRefPubMedGoogle Scholar
  2. Wallace CA, Hallman JR, Sangueza OP. Primary cutaneous ganglioneuroma: a report of two cases and literature review. Am J Dermatopathol. 2003;25:239–42.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.SeattleUSA
  2. 2.Department of PathologyEssentia Health, Duluth ClinicDuluthUSA

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