Abstract
Neurofibroma (NF) is one of the most commonly encountered benign peripheral nerve sheath tumors in the skin (Fig.a, b for line drawing). Because NF is composed of each element of the peripheral nerve, it most likely represents a hamartoma. Some authors, however, contend NF is a neoplasm as it is associated with mutation in the neurofibromatosis type 1 (NF1) gene. Furthermore, neurofibroma may undergo malignant transformation to malignant peripheral nerve sheath tumor. This occurs most often in patients with NF1.
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Additional Reading
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Argenyi, Z., Jokinen, C.H. (2011). Benign Cutaneous Neoplasms with Peripheral Nerve Differentiation. In: Cutaneous Neural Neoplasms. Current Clinical Pathology. Humana Press. https://doi.org/10.1007/978-1-60327-582-8_4
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