Benign Cutaneous Neoplasms with Peripheral Nerve Differentiation
Neurofibroma (NF) is one of the most commonly encountered benign peripheral nerve sheath tumors in the skin (Fig.a, b for line drawing). Because NF is composed of each element of the peripheral nerve, it most likely represents a hamartoma. Some authors, however, contend NF is a neoplasm as it is associated with mutation in the neurofibromatosis type 1 (NF1) gene. Furthermore, neurofibroma may undergo malignant transformation to malignant peripheral nerve sheath tumor. This occurs most often in patients with NF1.
KeywordsBenign cutaneous neural neoplasms Classification Histogenesis Diagnostic features Differential diagnosis Common neurofibroma Neurofibroma variants Common schwannoma Schwannoma variants Granular cell tumor Nerve sheath myxoma Perineurioma Lipoblastic nerve sheath tumors
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Granular Cell Tumor
Nerve Sheath Myxoma
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