Special Techniques for the Study of Cutaneous Neural Tumors

  • Zsolt ArgenyiEmail author
  • Chris H. Jokinen
Part of the Current Clinical Pathology book series (CCPATH)


A variety of histochemical and immunohistochemical methods, if employed in the appropriate context and in a suitable combination, are useful for identifying and classifying cutaneous neural tumors.


Diagnostic techniques Special stains Histochemistry Immunohistochemistry Electronmicroscopy Molecular biology Cytogenetics 

Additional Reading

  1. Asthagiri AR, Parry DM, Butman JA, Kim HJ, Tsilou ET, Zhuang Z, et al. Neurofibromatosis type 2. Lancet. 2009;373:1974.CrossRefPubMedGoogle Scholar
  2. Boyd KP, Korf BR, Theos A. Neurofibromatosis type 1. J Am Acad Dermatol. 2009;61:1.CrossRefPubMedGoogle Scholar
  3. Brock JE, Perez-Atayde AR, Kozakewich HP, Richkind KE, Fletcher JA, Vargas SO. Cytogenetic aberrations in perineurioma: variation with subtype. Am J Surg Pathol. 2005;29:1164.CrossRefPubMedGoogle Scholar
  4. De Vitis LR, Tedde A, Vitelli F, Ammannati F, Mennonna P, Bigozzi U, et al. Screening for mutations in the neurofibromatosis type 2 (NF2) gene in sporadic meningiomas. Hum Genet. 1996;97:632.CrossRefPubMedGoogle Scholar
  5. Giannini C, Scheithauer BW, Jenkins RB, Erlandson RA, Perry A, Borell TJ, et al. Soft-tissue perineurioma. Evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature. Am J Surg Pathol. 1997;21:164.CrossRefPubMedGoogle Scholar
  6. Lasota J, Fetsch JF, Wozniak A, Wasag B, Sciot R, Miettinen M. The neurofibromatosis type 2 gene is mutated in perineurial cell tumors: a molecular genetic study of eight cases. Am J Pathol. 2001;158:1223.CrossRefPubMedGoogle Scholar
  7. Mott RT, Goodman BK, Burchette JL, Cummings TJ. Loss of chromosome 13 in a case of soft tissue perineurioma. Clin Neuropathol. 2005;24:69.PubMedGoogle Scholar
  8. Sciot R, Dal Cin P, Hagemeijer A, De Smet L, Van Damme B, Van den Berghe H. Cutaneous sclerosing perineurioma with cryptic NF2 gene deletion. Am J Surg Pathol. 1999;23:849.CrossRefPubMedGoogle Scholar
  9. Twist EC, Ruttledge MH, Rousseau M, Sanson M, Papi L, Merel P, et al. The neurofibromatosis type 2 gene is inactivated in schwannomas. Hum Mol Genet. 1994;3:147.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.SeattleUSA
  2. 2.Department of PathologyEssentia Health, Duluth ClinicDuluthUSA

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