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Effects of Intermittent Hypoxia on Neurological Function

  • Chapter
Brain Hypoxia and Ischemia

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

Sleep-disordered breathing is a frequent condition across the age spectrum in the clinical setting, and is characterized by recurring episodes of hypoxia during sleep, as well as by disruption of sleep integrity. It has become clear that this highly prevalent condition leads to substantial morbidities primarily affecting the central nervous and cardiovascular systems and is also associated with marked alterations in respiratory patterning. Substantial advances have occurred in the last decade on our understanding of the pathophysiological role played intermittent hypoxia in these altered phenotypes. In this chapter, the current conceptual frameworks on the mechanisms underlying the consequences of episodic hypoxemia during sleep will be reviewed, with particular attention to cognitive deficits and altered neural control of breathing. When appropriate, differences in the response patterns as dictated by developmental stages at which intermittent hypoxia occurs will also be addressed.

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  1. Department of Pediatrics, Comer Children's Hospital, The University of Chicago, 5721 S. Maryland Avenue, MC 8000, Suite K-160, Chicago, IL 60637

    David Gozal

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  1. University of California, San Diego, CA

    Gabriel G. Haddad

  2. Rady Children's Hospital, San Diego, CA

    Gabriel G. Haddad

  3. Emory University, Atlanta, GA

    Shan Ping Yu

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Gozal, D. (2009). Effects of Intermittent Hypoxia on Neurological Function. In: Haddad, G.G., Yu, S.P. (eds) Brain Hypoxia and Ischemia. Contemporary Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-60327-579-8_9

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