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Brain Hypoxia and Ischemia pp 43–52Cite as

Brain Ischemia and Neuronal Excitability

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Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

Selective neuronal death in certain brain regions has long been recognized as a consequence of transient cerebral ischemia; however, its mechanisms remain unclear. Growing evidence indicates that an increase in neuronal excitability may contribute to this process. Both excitatory synaptic inputs and voltage-dependent potassium currents are important for regulating neuronal excitability. Recent studies demonstrate that the activities of excitatory synaptic inputs and potassium channels are differentially altered in ischemia-sensitive and ischemia-resistant neurons after ischemic insults. It is suggested that a suppression of excitatory neurotransmission or an enhancement of voltage-dependent potassium currents may protect neurons against cerebral ischemia.

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Author information

Authors and Affiliations

  1. Department of Anatomy and Cell Biology, Indiana University School of Medicine, IN 46202, Indianapolis, USA

    Ping Deng & Zao C. Xu

Authors
  1. Ping Deng
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  2. Zao C. Xu
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Editors and Affiliations

  1. University of California, San Diego, CA

    Gabriel G. Haddad

  2. Rady Children's Hospital, San Diego, CA

    Gabriel G. Haddad

  3. Emory University, Atlanta, GA

    Shan Ping Yu

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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Deng, P., Xu, Z.C. (2009). Brain Ischemia and Neuronal Excitability. In: Haddad, G.G., Yu, S.P. (eds) Brain Hypoxia and Ischemia. Contemporary Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-60327-579-8_3

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