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Antioxidant and B-vitamins and Atherosclerosis

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Preventive Nutrition

Part of the book series: Nutrition and Health ((NH))

Abstract

Cardiovascular disease (CVD) is the main cause of death in Western countries. It is well accepted that high intake of fruits and vegetables has a significant role in the prevention of many chronic diseases such as CVD, cancer, and degenerative brain disorders (1). Due to the complexity of the nutrient content of fruits and vegetables, identification of specific nutrients responsible for cardioprotection is challenging. Collectively, the likely substances that provide the beneficial effects of fruits and vegetables include antioxidant vitamins and B-vitamins.

Key Points

Atherosclerosis is an interlinked inflammatory free-radical process.

Observational studies suggest that antioxidant and B-vitamins may reduce cardiovascular disease.

Randomized controlled trials have not substantiated a reduction in cardiovascular disease with antioxidant or B-vitamin supplementation.

Randomized controlled trials raise a level of concern for the safety of certain antioxidant vitamin supplementation under certain conditions.

Current data do not support the use of antioxidant or B-vitamin supplementation for the prevention or treatment of cardiovascular disease.

Consumption of fruits and vegetables high in antioxidant and B-vitamins appears to be an important component of a healthy dietary intake and lifestyle.

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Authors and Affiliations

  1. Department of Pharmacology and Pharmaceutical Sciences, Atherosclerosis Research Unit, School of Pharmacy, University of Southern California, 90033, Los Angeles, CA, USA

    Juliana Hwang-Levine PHARM.D

  2. Department of Preventive Medicine, Atherosclerosis Research Unit, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA

    Wendy J. Mack PHD

  3. Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA

    Howard N. Hodis MD

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  1. Juliana Hwang-Levine PHARM.D
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  3. Howard N. Hodis MD
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Correspondence to Juliana Hwang-Levine PHARM.D .

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    Adrianne Bendich

  2. Inst. Human Nutrition, Columbia University, West 168th St. 630 , New York, 10032, U.S.A.

    Richard J. Deckelbaum

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Hwang-Levine, J., Mack, W.J., Hodis, H.N. (2010). Antioxidant and B-vitamins and Atherosclerosis. In: Bendich, A., Deckelbaum, R. (eds) Preventive Nutrition. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-60327-542-2_12

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