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Public Health Benefits of Preventive Nutrition

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Preventive Nutrition

Part of the book series: Nutrition and Health ((NH))

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Key Points

  • Staying lean and physically active throughout adult life has major health benefits.

  • Diets low in the percentage of energy from fat have not been associated with lower risks of heart disease, cancer, or better long-term weight control.

  • Avoiding industrially produced trans fat, keeping saturated fat low, and emphasizing unsaturated fats will minimize risks of heart disease and type 2 diabetes.

  • Consuming grains in their original high fiber/whole grain form is likely to reduce risk of type 2 diabetes and heart disease. Consumption of sugary beverages increases risk of type 2 diabetes and probably heart disease. High intake of fruits and vegetables will help prevent risks of cardiovascular disease, but the benefits for cancer reduction appear modest.

  • High consumption of alcohol and alcoholism have many adverse health and social consequences, and intakes as low as one drink per day or less are associated with greater risks of breast cancer. In contrast, moderate consumption of alcohol reduces risks of coronary heart disease and type 2 diabetes.

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References

  1. Puska P, Vartiainen E, Tuomilehto J, Salomaa V, Nissinen A. Changes in premature deaths in Finland: successful long-term prevention of cardiovascular diseases. Bull World Health Organ 1998;76:419–425.

    CAS  PubMed  Google Scholar 

  2. Bosetti C, Malvezzi M, Chatenoud L, Negri E, Levi F, La Vecchia C. Trends in colorectal cancer mortality in Japan, 1970–2000. Int J Cancer 2005;113:339–341.

    Article  CAS  PubMed  Google Scholar 

  3. Ludwig DS. Childhood obesity—the shape of things to come. N Engl J Med 2007;357:2325–2327.

    Article  CAS  PubMed  Google Scholar 

  4. Willett WC. Balancing life-style and genomics research for disease prevention. Science. 2002;296:695–698.

    Article  CAS  PubMed  Google Scholar 

  5. World Health Organization, FAO. Diet, nutrition and the prevention of chronic diseases: report of a joint WHO/FAO expert consultation (Report 916). World Health Organization, Geneva, 2003.

    Google Scholar 

  6. Willett WC. Nutritional Epidemiology, 2nd Ed. Oxford University Press, New York, 1998.

    Google Scholar 

  7. Department of Health and Human Services. The Surgeon General’s Report on Nutrition and Health, Government Printing Office, Washington, DC (DHHS publication [PHS] 50210), 1988.

    Google Scholar 

  8. U.S. Department of Agriculture, U.S. Department of Health and Human Services. Nutrition and Your Health: Dietary Guidelines for Americans, 5th Ed. U.S. Government Printing Office, Washington, DC, 2000.

    Google Scholar 

  9. World Health Organization. Obesity: preventing and managing the global epidemic. WHO Technical Report Series no 894. ISBN no. 92 4 120894 5Geneva, 3–5 June 1997. World Health Organization, Geneva 2000.

    Google Scholar 

  10. Keys A. Serum-cholesterol response to dietary cholesterol. Am J Clin Nutr 1984;40:351–359.

    CAS  PubMed  Google Scholar 

  11. Hegsted DM. Serum-cholesterol response to dietary cholesterol: a re-evaluation. Am J Clin Nutr 1986;44:299–305.

    CAS  PubMed  Google Scholar 

  12. Castelli WP, Abbott RD, McNamara PM. Summary estimates of cholesterol used to predict coronary heart disease. Circulation 1983;67:730–734.

    CAS  PubMed  Google Scholar 

  13. Ginsberg HN, Barr SL, Gilbert A, et al. Reduction of plasma cholesterol levels in normal men on an American Heart Association Step 1 diet or a Step 1 diet with added monounsaturated fat. N Engl J Med 1990;322:574–579.

    Article  CAS  PubMed  Google Scholar 

  14. Mensink RP, Zock PL, Kester AD, Katan MB. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 2003;77:1146–1155.

    CAS  PubMed  Google Scholar 

  15. Garg A, Grundy SM, Koffler M. Effect of high carbohydrate intake on hyperglycemia, islet cell function, and plasma lipoproteins in NIDDM. Diabetes Care 1992;15:1572–1580.

    Article  CAS  PubMed  Google Scholar 

  16. Brinton EA, Eisenberg S, Breslow JL. Increased apo A-I and apo A-II fractional catabolic rate in patients with low high density lipoprotein-cholesterol levels with or without hypertriglyceridemia. J Clin Invest 1991;87:536–544.

    Article  CAS  PubMed  Google Scholar 

  17. Sacks FM, Willett WC. More on chewing the fat—the good fat and the good cholesterol. N Engl J Med 1991;325: 1740–1742.

    Article  CAS  PubMed  Google Scholar 

  18. Mänttäri M, Huttunen JK, Koskinen P, et al. Lipoproteins and coronary heart disease in the Helsinki Heart Study. Eur Heart J 1990;11:26 h–31 h.

    Google Scholar 

  19. Mensink RP, Katan MB. Effect of dietary fatty acids on serum lipids and lipoproteins: a meta-analysis of 27 trials. Arterioscler Thromb 1992;12:911–919.

    CAS  PubMed  Google Scholar 

  20. Denke MA, Grundy SM. Effects of fats high in stearic acid on lipid and lipoprotein concentrations in men. Am J Clin Nutr 1991;54:1036–1040.

    CAS  PubMed  Google Scholar 

  21. Hu FB, Stampfer MJ, Manson JE, et al. Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women. Am J Clin Nutr 1999;70:1001–1008.

    CAS  PubMed  Google Scholar 

  22. Kabagambe EK, Baylin A, Siles X, Campos H. Individual saturated fatty acids and nonfatal acute myocardial infarction in Costa Rica. Eur J Clin Nutr 2003;57:1447–1457.

    Article  CAS  PubMed  Google Scholar 

  23. Sundram K, Karupaiah T, Hayes KC. Stearic acid-rich interesterified fat and trans-rich fat raise the LDL/HDL ratio and plasma glucose relative to palm olein in humans. Nutr Metab (Lond) 2007;4:3.

    Article  CAS  Google Scholar 

  24. Welsch CW. Relationship between dietary fat and experimental mammary tumorigenesis: a review and critique. Cancer Res 1992;52(Suppl. 7):2040S–2048S.

    CAS  PubMed  Google Scholar 

  25. Renaud S, Kuba K, Goulet C, Lemire Y, Allard C. Relationship between fatty-acid composition of platelets and platelet aggregation in rat and man. Relation to thrombosis. Circ Res 1970;26:553–564.

    CAS  PubMed  Google Scholar 

  26. Leaf A, Weber PC. Cardiovascular effects of n-3 fatty acids. N Engl J Med 1988;318:549–557.

    Article  CAS  PubMed  Google Scholar 

  27. Keys A. Seven Countries: A Multivariate Analysis of Death and Coronary Heart Disease. Harvard University Press, Cambridge, MA, 1980.

    Google Scholar 

  28. Verschuren WM, Jacobs DR, Bloemberg BP, et al. Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five-year follow-up of the Seven Countries Study. J Am Med Assoc 1995;274: 131–136.

    Article  CAS  Google Scholar 

  29. Shekelle RB, Shryock AM, Paul O, et al. Diet, serum cholesterol, and death from coronary heart disease: The Western Electric Study. N Engl J Med 1981;304:65–70.

    Article  CAS  PubMed  Google Scholar 

  30. Hu F, Stampfer MJ, Manson JE, et al. Dietary fat intake and the risk of coronary heart disease in women. N Engl J Med 1997;337:1491–1499.

    Article  CAS  PubMed  Google Scholar 

  31. Shekelle RB, Stamler J. Dietary cholesterol and ischemic heart disease. Lancet 1989;1:1177–1179.

    Article  CAS  PubMed  Google Scholar 

  32. Multiple Risk Factor Intervention Trial Research Group. Multiple Risk Factor Intervention Trial: risk factor changes and mortality results. J Am Med Assoc 1982;248:1465–1477.

    Google Scholar 

  33. Stamler J, Wentworth D, Neaton JD. Is the relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT). JAMA 1986;256:2823–2828.

    Article  CAS  PubMed  Google Scholar 

  34. Frantz IDJ, Dawson EA, Ashman PL, et al. Test of effect of lipid lowering by diet on cardiovascular risk: the Minnesota Coronary Survey. Arteriosclerosis 1989;9:129–135.

    PubMed  Google Scholar 

  35. Sacks F. Dietary fats and coronary heart disease. Overview. J Cardiovascular Risk 1994;1:3–8.

    Article  CAS  Google Scholar 

  36. Howard BV, Van Horn L, Hsia J, et al. Low-fat dietary pattern and risk of cardiovascular disease: the Women’s Health Initiative Randomized Controlled Dietary Modification Trial. JAMA 2006;295:655–666.

    Article  CAS  PubMed  Google Scholar 

  37. Mozaffarian D, Abdollahi M, Campos H, Houshiarrad A, Willett WC. Consumption of trans fats and estimated effects on coronary heart disease in Iran. Eur J Clin Nutr 2007;61:1004–1010.

    Article  CAS  PubMed  Google Scholar 

  38. Booyens J, Louwrens CC. The Eskimo diet. Prophylactic effects ascribed to the balanced presence of natural cis unsaturated fatty acids and to the absence of unnatural trans and cis isomers of unsaturated fatty acids. Med Hypotheses 1986;21:387–408.

    Article  CAS  PubMed  Google Scholar 

  39. Mensink RPM, Katan MB. Effect of dietary trans-fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects. N Engl J Med 1990;323:439–445.

    Article  CAS  PubMed  Google Scholar 

  40. Zock PL, Katan MB. Hydrogenation alternatives: effects of trans fatty acids and stearic acid versus linoleic acid on serum lipids and lipoproteins in humans. J Lipid Res 1992;33:399–410.

    CAS  PubMed  Google Scholar 

  41. Judd JT, Clevidence BA, Muesing RA, Wittes J, Sunkin ME, Podczasy JJ. Dietary trans fatty acids: effects of plasma lipids and lipoproteins on healthy men and women. Am J Clin Nutr 1994;59:861–868.

    CAS  PubMed  Google Scholar 

  42. Nestel P, Noakes M, Belling Bea. Plasma lipoprotein and Lp[a] changes with substitution of elaidic acid for oleic acid in the diet. J Lipid Res 1992;33:1029–1036.

    CAS  PubMed  Google Scholar 

  43. Sundram K, Ismail A, Hayes KC, Jeyamalar R, Pathmanathan R. Trans (elaidic) fatty acids adversely affect the lipoprotein profile relative to specific saturated fatty acids in humans. J Nutr 1997;127:514S–520S.

    CAS  PubMed  Google Scholar 

  44. Mozaffarian D, Katan MB, Ascherio A, Stampfer MJ, Willett WC. Trans fatty acids and cardiovascular disease. N Engl J Med 2006;354:1601–1613.

    Article  CAS  PubMed  Google Scholar 

  45. Mensink RP, Zock PL, Katan MB, Hornstra G. Effect of dietarycis and trans fatty acids on serum lipoprotein [a] levels in humans. J Lipid Res 1992;33:1493–1501.

    CAS  PubMed  Google Scholar 

  46. Mozaffarian D, Willett WC. Trans fatty acids and cardiovascular risk: a unique cardiometabolic imprint? Curr Atheroscler Rep 2007;9:486–493.

    Article  CAS  PubMed  Google Scholar 

  47. Kromhout D, Menotti A, Bloemberg B, et al. Dietary saturated and trans fatty acids and cholesterol and 25-year mortality from coronary heart disease: the Seven Countries Study. Prev Med 1995;24:308–315.

    Article  CAS  PubMed  Google Scholar 

  48. Hu FB, Manson JE, Stampfer MJ, et al. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 2001;345:790–797.

    Article  CAS  PubMed  Google Scholar 

  49. Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. Long-term intake of trans-fatty acids and risk of gallstone disease in men. Arch Intern Med 2005;165:1011–1015.

    Article  CAS  PubMed  Google Scholar 

  50. Morris MC, Evans DA, Bienias JL, Tangney CC, Wilson RS. Dietary fat intake and 6-year cognitive change in an older biracial community population. Neurology 2004;62:1573–1579.

    CAS  PubMed  Google Scholar 

  51. Field AE, Willett WC, Lissner L, Colditz GA. Dietary fat and weight gain among women in the Nurses’ Health Study. Obesity (Silver Spring) 2007;15:967–976.

    Article  Google Scholar 

  52. Kavanagh K, Jones KL, Sawyer J, et al. Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys. Obesity (Silver Spring) 2007;15:1675–1684.

    Article  CAS  Google Scholar 

  53. Bonaa KH, Bzerve KS, Staume B, Gram IT, Thelle D. Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension: a population-based intervention trial from the Tromso study. N Engl J Med 1990;322: 795–801.

    Article  CAS  PubMed  Google Scholar 

  54. Kestin M, Clifton P, Belling GB, Nestel PJ. N-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. Am J Clin Nutr 1990;51: 1028–1034.

    CAS  PubMed  Google Scholar 

  55. Kromhout D, Bosscheiter EB, de Lezenne Coulander C. The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med 1985;312:1205–1209.

    Article  CAS  PubMed  Google Scholar 

  56. Burr ML, Fehily AM, Gilbert JF, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 1989;2:757–761.

    Article  CAS  PubMed  Google Scholar 

  57. Vollset SE, Heuch I, Bjelke E. Fish consumption and mortality from coronary heart disease (letter). N Engl J Med 1985;313:820–821.

    Article  Google Scholar 

  58. Ascherio A, Rimm EB, Stampfer MJ, Giovannucci E, Willett WC. Dietary intake of marine n-3 fatty acids, fish intake and the risk of coronary disease among men. N Engl J Med 1995;332:977–982.

    Article  CAS  PubMed  Google Scholar 

  59. Morris MC, Manson JE, Rosner B, Buring JE, Willett WC, Hennekens CH. Fish consumption and cardiovascular disease in the Physicians’ Health Study: a prospective study. Am J Epidemiol 1995;142:166–175.

    CAS  PubMed  Google Scholar 

  60. de Lorgeril M, Renaud S, Mamelle N, et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease [Erratum in: Lancet 1995;345:738]. Lancet 1994;343:1454–1459.

    Article  PubMed  Google Scholar 

  61. Leaf A. Omega-3 fatty acids and prevention of ventricular fibrillation. Prostaglandins Leukot Essent Fatty Acids 1995;52:197–198.

    Article  CAS  PubMed  Google Scholar 

  62. GISSI-Prevention Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999;354:447–455.

    Google Scholar 

  63. Campos H, Baylin A, Willett WC. Alpha-linolenic acid and risk of nonfatal acute myocardial infarction. Circulation 2008;118:339–345.

    Article  CAS  PubMed  Google Scholar 

  64. Zatonski W, Campos H, Willett W. Rapid declines in coronary heart disease mortality in Eastern Europe are associated with increased consumption of oils rich in alpha-linolenic acid. Eur J Epidemiol 2008;23:3–10.

    Article  CAS  PubMed  Google Scholar 

  65. National Research Council—Committee on Diet and Health. Diet and Health: Implications for Reducing Chronic Disease Risk, National Academy Press, Washington, DC. 1989.

    Google Scholar 

  66. Prentice RL, Sheppard L. Dietary fat and cancer. Consistency of the epidemiologic data, and disease prevention that may follow from a practical reduction in fat consumption. Cancer Causes Control 1990;1:81–97.

    Article  CAS  PubMed  Google Scholar 

  67. Armstrong B, Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer 1975;15:617–631.

    Article  CAS  PubMed  Google Scholar 

  68. Ip C. Quantitative assessment of fat and calorie as risk factors in mammary carcinogenesis in an experimental model. In: Mettlin CJ, Aoki K, eds. Recent Progress in Research on Nutrition and Cancer: Proceedings of a Workshop Sponsored by the International Union Against Cancer, Held in Nagoya, Japan, November 1–3, 1989. Wiley-Liss, Inc., New York, 1990, pp. 107–117.

    Google Scholar 

  69. Freedman LS, Clifford C, Messina M. Analysis of dietary fat, calories, body weight, and the development of mammary tumors in rats and mice: a review. Cancer Res 1990;50:5710–5719.

    CAS  PubMed  Google Scholar 

  70. Appleton BS, Landers RE. Oil gavage effects on tumor incidence in the National Toxicology Program’s 2-year carcinogenesis bioassay. Adv Exp Med Biol 1986;206:99–104.

    CAS  PubMed  Google Scholar 

  71. Kushi LH, Sellers TA, Potter JD, et al. Dietary fat and postmenopausal breast cancer. J Natl Cancer Inst 1992;84: 1092–1099.

    Article  CAS  PubMed  Google Scholar 

  72. Howe GR, Friedenreich CM, Jain M, Miller AB. A cohort study of fat intake and risk of breast cancer. J Natl Cancer Inst 1991;83:336–340.

    Article  CAS  PubMed  Google Scholar 

  73. Graham S, Zielezny M, Marshall J, et al. Diet in the epidemiology of postmenopausal breast cancer in the New York State cohort. Am J Epidemiol 1992;136:1327–1337.

    CAS  PubMed  Google Scholar 

  74. Van den Brandt PA, Van’t Veer P, Goldbohm RA, et al. A prospective cohort study on dietary fat and the risk of postmenopausal breast cancer. Cancer Res 1993;53:75–82.

    PubMed  Google Scholar 

  75. Smith-Warner SA, Spiegelman D, Adami HO, et al. Types of dietary fat and breast cancer: a pooled analysis of cohort studies. Int J Cancer 2001;92:767–774.

    Article  CAS  PubMed  Google Scholar 

  76. Kim EH, Willett WC, Colditz GA, et al. Dietary fat and risk of postmenopausal breast cancer in a 20-year follow-up. Am J Epidemiol 2006;164:990–997.

    Article  PubMed  Google Scholar 

  77. Thiebaut A, Kipnis V, Chang S-C, et al. Dietary fat and postmenopausal invasive breast cancer in the National Institutes of Health—AARP Diet and Health Study Cohort. J Natl Cancer Inst 2007;99:451–462.

    Article  PubMed  Google Scholar 

  78. Holmes MD, Hunter DJ, Colditz GA, et al. Association of dietary intake of fat and fatty acids with risk of breast cancer. JAMA 1999;281:914–920.

    Article  CAS  PubMed  Google Scholar 

  79. Prentice RL, Thomson CA, Caan B, et al. Low-fat dietary pattern and cancer incidence in the Women’s Health Initiative Dietary Modification Randomized Controlled Trial. J Natl Cancer Inst 2007;99:1534–1543.

    Article  PubMed  Google Scholar 

  80. Cho E, Spiegelman D, Hunter DJ, et al. Premenopausal fat intake and risk of breast cancer. J Natl Cancer Inst 2003;95:1079–1085.

    Article  PubMed  Google Scholar 

  81. W.C.R.F./A.I.C.R. Second Expert Report: Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective, 2007.

    Google Scholar 

  82. Willett WC, Stampfer MJ, Colditz GA, Rosner BA, Speizer FE. Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women. N Engl J Med 1990;323:1664–1672.

    Article  CAS  PubMed  Google Scholar 

  83. Giovannucci E, Rimm EB, Ascherio A, Stampfer MJ, Colditz GA, Willett WC. Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst 1995;87:265–273.

    Article  CAS  PubMed  Google Scholar 

  84. Norat T, Lukanova A, Ferrari P, Riboli E. Meat consumption and colorectal cancer risk: dose-response meta-analysis of epidemiological studies. Int J Cancer 2002;98:241–256.

    Article  CAS  PubMed  Google Scholar 

  85. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003;348:1625–1638.

    Article  PubMed  Google Scholar 

  86. Seidell JC, Derenberg I. Obesity in Europe—prevalences and consequences for use of medical care. Pharmacoeconomics 1994;5(Suppl. 1):38–44.

    Article  CAS  PubMed  Google Scholar 

  87. Chen X, Yang GQ, Chen J, Chen X, Wen Z, Ge K. Studies on the relations of selenium and Keshan disease. Biol Trace Elem Res 1980;2:91–107.

    Article  CAS  Google Scholar 

  88. Willett WC, Leibel RL. Dietary fat is not a major determinant of body fat. Am J Med 2002;113(Suppl. 9B):47S–59S.

    Article  PubMed  Google Scholar 

  89. Dansinger ML, Gleason JA, Griffith JL, Selker HP, Schaefer EJ. Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA 2005;293:43–53.

    Article  CAS  PubMed  Google Scholar 

  90. Shai I, Schwarzfuchs D, Henkin Y, et al. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med 2008;359:229–241.

    Article  CAS  PubMed  Google Scholar 

  91. Shintani TT, Hughes CK, Beckman S, O’Connor HK. Obesity and cardiovascular risk intervention through the ad libitum feeding of a traditional Hawaiian diet. Am J Clin Nutr 1991;6:1647 s–1651 s.

    Google Scholar 

  92. Hung HC, Joshipura KJ, Jiang R, et al. Fruit and vegetable intake and risk of major chronic disease. J Natl Cancer Inst 2004;96:1577–584.

    Article  PubMed  Google Scholar 

  93. Block G, Patterson B, Subar A. Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 1992;18:1–29.

    Article  CAS  PubMed  Google Scholar 

  94. Steinmetz KA, Potter JD. Vegetables, fruit and cancer. I. Epidemiology. Cancer Causes Control 1991;2:325– 357.

    Article  CAS  PubMed  Google Scholar 

  95. Michels KB, Giovannucci E, Joshipura KJ, et al. Fruit and vegetable consumption and colorectal cancer incidence. IARC Sci Publ 2002;156:139–140.

    CAS  PubMed  Google Scholar 

  96. Smith-Warner SA, Spiegelman D, Yaun SS, et al. Intake of fruits and vegetables and risk of breast cancer: a pooled analysis of cohort studies. JAMA 2001;285:769–776.

    Article  CAS  PubMed  Google Scholar 

  97. Block G, Abrams B. Vitamin and mineral status of women of childbearing potential. Ann N Y Acad Sci 1993;678: 244–254.

    Article  CAS  PubMed  Google Scholar 

  98. Giovannucci E, Stampfer MJ, Colditz GA, et al. Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst 1993;85:875–884.

    Article  CAS  PubMed  Google Scholar 

  99. Sacks FM, Obarzanek E, Windhauser MM, et al. Rationale and design of the Dietary Approaches to Stop Hypertension Trial (DASH)—A multicenter controlled-feeding study of dietary patterns to lower blood pressure. Annu Epidemiol 1995;5:108–118.

    Article  CAS  Google Scholar 

  100. Sacks FM, Willett WC, Smith A, Brown LE, Rosner B, Moore TJ. Effect on blood pressure of potassium, calcium, and magnesium in women with low habitual intake. Hypertension 1998;31:131–138.

    CAS  PubMed  Google Scholar 

  101. Stampfer MJ, Malinow MR, Willett WC, et al. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. J Am Med Assoc 1992;268:877–881.

    Article  CAS  Google Scholar 

  102. Kang SS, Wong PWK, Norusis M. Homocysteinemia due to folate deficiency. Metabolism 1987;36:458–462.

    Article  CAS  PubMed  Google Scholar 

  103. Selhub J, Jacques PF, Bostom AG, et al. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med 1995;332:286–291.

    Article  CAS  PubMed  Google Scholar 

  104. Kang SS, Wong PWK, Cook HY, Norusis M, Messer JV. Protein bound homocyst(e)ine—a possible risk factor for coronary artery disease. J Clin Invest 1986;77:1482–1486.

    Article  CAS  PubMed  Google Scholar 

  105. Wilcken DEL, Dudman NPB, Tyrrell PA. Homocystinuria due to cystathionine B-synthase deficiency—the effects of betaine treatment in pyridoxine-responsive patients. Metabolism 1985;34:1115–1121.

    Article  CAS  PubMed  Google Scholar 

  106. Wang X, Qin X, Demirtas H, et al. Efficacy of folic acid supplmentation in stroke prevention: a meta-analysis. Lancet 2007;369:1876–1882.

    Article  CAS  PubMed  Google Scholar 

  107. Wald DS, Wald NJ, Morris JK, Law M. Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence. BMJ 2006;333:1114–1117.

    Article  CAS  PubMed  Google Scholar 

  108. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991;338:131–137.

    Google Scholar 

  109. Werler MM, Shapiro S, Mitchell AA. Periconceptional folic acid exposure and risk of occurrent neural tube defects. JAMA 1993;269:1257–1261.

    Article  CAS  PubMed  Google Scholar 

  110. van der Put NM, Steegers-Theunissen RP, Frosst P, et al. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 1995;346:1070–1071.

    Article  PubMed  Google Scholar 

  111. Jacques PF, Hartz SC, Chylack LT, McGandy RB, Sadowski JA. Nutritional status in persons with and without senile cataract: blood vitamin and mineral levels. Am J Clin Nutr 1988;48:152–158.

    CAS  PubMed  Google Scholar 

  112. Hankinson SE, Stampfer MJ, Seddon JM, et al. Nutrient intake and cataract extraction in women: a prospective study. Br Med J 1992;305:335–339.

    Article  CAS  Google Scholar 

  113. Chasan-Taber L, Willett WC, Seddon JM, et al. A propective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509–516.

    CAS  PubMed  Google Scholar 

  114. Hankinson SE, Willett WC, Colditz GA, et al. A prospective study of smoking and risk of cataract surgery in women. J Am Med Assoc 1992;268:994–998.

    Article  CAS  Google Scholar 

  115. Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. J Am Med Assoc 1994;272:1413–1420.

    Article  CAS  Google Scholar 

  116. Schalch W. Carotenoids in the retina: a review of their possible role in preventing or limiting damage caused by light and oxygen. In: Emerit I, Chance B, eds. Free Radicals and Aging. Birkhauser Verlag, Basel, Switzerland, 1992, pp. 280–298.

    Google Scholar 

  117. Jeppesen J, Hollenbeck CB, Zhou MY, et al. Relation between insulin resistance, hyperinsulemia, postheparin plasma lipoprotein lipase activity, and postprandial lipemia. Arterioscler Thromb Vasc Biol 1995;15:320–324.

    CAS  PubMed  Google Scholar 

  118. Jeppesen J, Chen YDI, Zhou MY, Schaaf P, Coulston A, Reaven GM. Postprandial triglyceride and retinyl ester responses to oral fats effects of fructose. Am J Clin Nutr 1995;61:787–791.

    CAS  PubMed  Google Scholar 

  119. Shai I, Jiang R, Manson JE, et al. Ethnicity, obesity, and risk of type 2 diabetes in women: a 20-year follow-up study. Diabetes Care 2006;29:1585–1590.

    Article  PubMed  Google Scholar 

  120. Jenkins DJ, Wolever TM, Taylor RH, et al. Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr 1981;34:362–366.

    CAS  PubMed  Google Scholar 

  121. Salmeron J, Manson JE, Stampfer MJ, Colditz GA, Wing AL, Willett WC. Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. JAMA 1997;277:472–477.

    Article  CAS  PubMed  Google Scholar 

  122. Salmeron J, Ascherio A, Rimm EB, et al. Dietary fiber, glycemic load, and risk of NIDDM in Men. Diabetes Care 1997;20:545–550.

    Article  CAS  PubMed  Google Scholar 

  123. Liu S, Willett WC, Stampfer MJ, et al. A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women. Am J Clin Nutr 2000;71:1455–1461.

    CAS  PubMed  Google Scholar 

  124. Morris JN, Marr JW, Clayton DG. Diet and heart: a postscript. Br Med J 1977;2:1307–1314.

    Article  CAS  PubMed  Google Scholar 

  125. Khaw KT, Barrett-Connor E. Dietary fiber and reduced ischemic heart disease mortality rates in men and women: a 12-year prospective study. Am J Epidemiol 1987;126:1093–1102.

    CAS  PubMed  Google Scholar 

  126. Hu FB, Willett WC. Optimal diets for prevention of coronary heart disease. JAMA 2002;288:2569–2578.

    Article  CAS  PubMed  Google Scholar 

  127. Rimm EB, Ascherio A, Giovannucci E, Spiegelman D, Stampfer MJ, Willett WC. Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men. J Am Med Assoc 1996;275:447–451.

    Article  CAS  Google Scholar 

  128. Willett W. The search for the causes of breast and colon cancer. Nature 1989;338:389–394.

    Article  CAS  PubMed  Google Scholar 

  129. Fuchs CS, Colditz GA, Stampfer MJ, et al. Dietary fiber and the risk of colorectal cancer and adenoma in women. N Engl J Med 1999;340:169–176.

    Article  CAS  PubMed  Google Scholar 

  130. Terry P, Giovannucci E, Michels KB, et al. Fruit, vegetables, dietary fiber, and risk of colorectal cancer. J Natl Cancer Inst 2001;93:525–533.

    Article  CAS  PubMed  Google Scholar 

  131. Jenkins DJ, Wolever TM, Rao AV, et al. Effect of blood lipids of very high intakes of fiber in diets low in saturated fat and cholesterol. N Engl J Med 1993;329:21–26.

    Article  CAS  PubMed  Google Scholar 

  132. Brown L, Rosner B, Willett WC, Sacks FM. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr 1999;69:30–42.

    CAS  PubMed  Google Scholar 

  133. Schroeder HA. Losses of vitamins and trace minerals resulting from processing and preservation of foods. Am J Clin Nutr 1971;24:562–573.

    CAS  PubMed  Google Scholar 

  134. Mason JB. Folate and colonic carcinogenesis: searching for a mechanistic understanding. J Nutr Biochem 1994;5: 170–175.

    Article  CAS  Google Scholar 

  135. Popkin BM, Armstrong LE, Bray GM, Caballero B, Frei B, Willett WC. A new proposed guidance system for beverage consumption in the United States. Am J Clin Nutr 2006;83:529–542.

    CAS  PubMed  Google Scholar 

  136. Schulze MB, Manson JE, Ludwig DS, et al. Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. JAMA 2004;292:927–934.

    Article  CAS  PubMed  Google Scholar 

  137. Lutz J, Linkswiler HM. Calcium metabolism in postmenopausal women and osteoporotic women consuming two levels of dietary protein. Am J Clin Nutr 1981;34:2178–2186.

    CAS  PubMed  Google Scholar 

  138. Gruberg ER, Raymond SA. Beyond Cholesterol. St. Martin’s, New York, 1981.

    Google Scholar 

  139. Youngman LD, Campbell TC. The sustained development of preneoplastic lesions depends on high protein intake. Nutr Cancer 1992;18:131–142.

    Article  CAS  PubMed  Google Scholar 

  140. Halton TL, Willett WC, Liu S, et al. Low-carbohydrate-diet score and the risk of coronary heart disease in women. N Engl J Med 2006;355:1991–2002.

    Article  CAS  PubMed  Google Scholar 

  141. Welsh S, Davis C, Shaw A. Development of the food guide pyramid. Nutr Today 1992;27:12–23.

    Article  Google Scholar 

  142. Chapuy MC, Arlof ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med 1992;327:1637–1642.

    Article  CAS  PubMed  Google Scholar 

  143. Heaney RP. Thinking straight about calcium. N Engl J Med 1993;328:503–504.

    Article  CAS  PubMed  Google Scholar 

  144. Bischoff-Ferrari HA, Dawson-Hughes B, Baron JA, et al. Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials. Am J Clin Nutr 2007;86:1780–1790.

    CAS  PubMed  Google Scholar 

  145. Institute of Medicine. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D, Fluoride. National Academy Press, Washington, DC, 1997.

    Google Scholar 

  146. Hegsted DM. Calcium and osteoporosis. J Nutr 1986;116:2316–2319.

    CAS  PubMed  Google Scholar 

  147. Holbrook TL, Barrett-Conner E, Wingard DL. Dietary calcium and risk of hip fracture: 14-year prospective population study. Lancet 1988;2:1046–1049.

    Article  CAS  PubMed  Google Scholar 

  148. Feskanich D, Willett WC, Colditz GA. Calcium, vitamin D, milk consumption, and hip fractures: a prospective study among postmenopausal women. Am J Clin Nutr 2003;77:504–11.

    CAS  PubMed  Google Scholar 

  149. Michaelsson K, Melhus H, Bellocco R, Wolk A. Dietary calcium and vitamin D intake in relation to osteoporotic fracture risk. Bone 2003;32:694–703.

    Article  CAS  PubMed  Google Scholar 

  150. Feskanich D, Willett WC, Colditz GA. Walking and leisure-time activity and risk of hip fracture in postmenopausal women. JAMA 2002;288:2300–2306.

    Article  PubMed  Google Scholar 

  151. Wickham CAC, Walsh K, Cooper C, et al. Dietary calcium, physical activity, and risk of hip fracture: a prospective study. Br Med J 1989;299:889–892.

    Article  CAS  Google Scholar 

  152. Michaelsson K, Holmberg L, Mallmin H, et al. Diet and hip fracture risk: a case-control study. Intl J Epidemiol 1995;24:771–782.

    Article  CAS  Google Scholar 

  153. Feskanich D, Willett WC, Stampfer MJ, Colditz GA. Milk, dietary calcium, bone fractures in women: a 12-year prospective study. Am J Public Health 1997;87:992–997.

    Article  CAS  PubMed  Google Scholar 

  154. Cho E, Smith-Warner S, Spiegelman D, et al. Dairy foods and calcium and colorectal cancer: a pooled analysis of 10 cohort studies. J Natl Cancer Inst 2004:96: 1015–1022.

    Google Scholar 

  155. Baron JA, Beach M, Mandel JS, et al. Calcium supplements for the prevention of colorectal adenomas. The Calcium Polyp Prevention Study Group. N Engl J Med 1999;340:101–107.

    Article  CAS  PubMed  Google Scholar 

  156. Giovannucci E, Rimm EB, Wolk A, et al. Calcium and fructose intake in relation to risk of prostate cancer. Cancer Res 1998;58:442–447.

    CAS  PubMed  Google Scholar 

  157. Giovannucci E. Nutritional and environmental epidemiology of prostate cancer. In: Kantoff PW, Carroll PR, D’Amico AV, eds. Prostate Cancer: Principles and Practice. Lippincott Williams & Wilkins, Philadelphia, PA, 2002, pp. 117–139.

    Google Scholar 

  158. Giovannucci E, Liu Y, Stampfer MJ, Willett WC. A prospective study of calcium intake and incident and fatal prostate cancer. Cancer Epidemiol Biomarkers Prev 2006;15:203–210.

    Article  CAS  PubMed  Google Scholar 

  159. Genkinger JM, Hunter DJ, Spiegelman D, et al. Dairy products and ovarian cancer: a pooled analysis of 12 cohort studies. Cancer Epidemiol Biomarkers Prev 2006;15:364–372.

    Article  PubMed  Google Scholar 

  160. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 2006;84:18–28.

    CAS  PubMed  Google Scholar 

  161. Giovannucci E. The epidemiology of vitamin D and cancer incidence and mortality: a review. Cancer Causes Control 2005:16: 83–95.

    Google Scholar 

  162. Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006;296:2832–2838.

    Article  CAS  PubMed  Google Scholar 

  163. Munger KL, Zhang SM, O'Reilly E, et al. Vitamin D intake and incidence of multiple sclerosis. Neurology 2004;62: 60–65.

    CAS  PubMed  Google Scholar 

  164. Broe KE, Chen TC, Weinberg J, Bischoff-Ferrari HA, Holick MF, Kiel DP. A higher dose of vitamin D reduces the risk of falls in nursing home residents: a randomized, multiple-dose study. J Am Geriatr Soc 2007;55:234–239.

    Article  PubMed  Google Scholar 

  165. Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med 2008;168:1174–1180.

    Article  CAS  PubMed  Google Scholar 

  166. Law MR, Frost CD, Wald NJ. By how much does dietary salt reduction lower blood pressure? III-Analysis of data from trials of salt reduction. Br Med J 1991;302:819–824.

    Article  CAS  Google Scholar 

  167. Correa P, Fontham E, Pickle LW, Chen V, Lin Y, Haenszel W. Dietary determinants of gastric cancer in south Louisiana inhabitants. J Natl Cancer Inst 1985;75:645–654.

    CAS  PubMed  Google Scholar 

  168. Willett WC, Dietz WH, Colditz GA. Guidelines for healthy weight. N Engl J Med 1999;341:427–434.

    Article  CAS  PubMed  Google Scholar 

  169. Garrison RJ, Kannel WB. A new approach for estimating healthy body weights. Int J Obesity 1993;17:417–423.

    CAS  Google Scholar 

  170. Lew EA, Garfinkel L. Variations in mortality by weight among 750,000 men and women. J Chronic Dis 1979;32: 563–576.

    Article  CAS  PubMed  Google Scholar 

  171. Willett WC, Manson JE, Stampfer MJ, et al. Weight, weight change, and coronary heart disease in women: risk within the “normal” weight range. J Am Med Assoc 1995;273:461–465.

    Article  CAS  Google Scholar 

  172. Colditz GA, Willett WC, Stampfer MJ, et al. Relative weight and increased risk of diabetes in a cohort of US women (abstract). Am J Epidemiol 1987;126:750–751.

    Google Scholar 

  173. Witteman JC, Willett WC, Stampfer MJ, et al. Relation of moderate alcohol consumption and risk of systemic hypertension in women. Am J Cardiol 1990;65:633–637.

    Article  CAS  PubMed  Google Scholar 

  174. International Agency for Research on Cancer. Weight Control and Physical Activity. IARCPress, Lyon, 2002.

    Google Scholar 

  175. Maclure KM, Hayes KC, Colditz GA, Stampfer MJ, Speizer FE, Willett WC. Weight, diet and risk of symptomatic gallstones in middle-aged women. N Engl J Med 1989;321:563–569.

    Article  CAS  PubMed  Google Scholar 

  176. Manson JE, Willett WC, Stampfer MJ, et al. Body weight and mortality among women. N Engl J Med 1995;333: 677–685.

    Article  CAS  PubMed  Google Scholar 

  177. van Dam RM, Seidell JC. Carbohydrate intake and obesity. Eur J Clin Nutr 2007;61 Suppl 1:S75–S99.

    PubMed  Google Scholar 

  178. Gortmaker SL, Dietz WH, Cheung LW. Inactivity, diet, and the fattening of America. J Am Diet Assoc 1990;90: 1247–1252.

    CAS  PubMed  Google Scholar 

  179. Klatsky AL, Armstrong MA, Friedman GD. Risk of cardiovascular mortality in alcohol drinkers, ex-drinkers, and nondrinkers. Am J Cardiol 1990;66:1237–1242.

    Article  CAS  PubMed  Google Scholar 

  180. Rimm EB, Giovannucci EL, Willett WC, et al. Prospective study of alcohol consumption and risk of coronary disease in men. Lancet 1991;338:464–468.

    Article  CAS  PubMed  Google Scholar 

  181. Rimm EB, Klatsky A, Grobbee D, Stampfer MJ. Review of moderate alcohol consumpton and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits? Br Med J 1996;312:731–736.

    CAS  Google Scholar 

  182. Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary disease. Lancet 1992;339:1523–1526.

    Article  CAS  PubMed  Google Scholar 

  183. Maclure M. Demonstration of deductive meta-analysis: ethanol intake and risk of myocardial infarction. Epidemiol Rev 1993;15:328–351.

    CAS  PubMed  Google Scholar 

  184. Mukamal KJ, Conigrave KM, Mittleman MA, et al. Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. N Engl J Med 2003;348:109–118.

    Article  PubMed  Google Scholar 

  185. Smith-Warner SA, Spiegelman D, Yaun S-S, et al. Alcohol and breast cancer in women: a pooled analysis of cohort studies. J Am Med Assoc 1998;279:535–540.

    Article  CAS  Google Scholar 

  186. Reichman ME, Judd JT, Longcope C, et al. Effects of alcohol consumption on plasma and urinary hormone concentrations in premenopausal women. J Natl Cancer Inst 1993;85:722–727.

    Article  CAS  PubMed  Google Scholar 

  187. Hankinson SE, Willett WC, Manson JE, et al. Alcohol, height, and adiposity in relation to estrogen and prolactin levels in postmenopausal women. J Natl Cancer Inst 1995;87:1297–1302.

    Article  CAS  PubMed  Google Scholar 

  188. Zhang S, Hunter DJ, Hankinson SE, et al. A prospective study of folate intake and the risk of breast cancer. JAMA 1999;281:1632–1637.

    Article  CAS  PubMed  Google Scholar 

  189. Boffetta P, Garfinkel L. Alcohol drinking and mortality among men enrolled in a American Cancer Society prospective study. Epidemiology 1990;1:342–348.

    Article  CAS  PubMed  Google Scholar 

  190. Fuchs CS, Stampfer MJ, Colditz GA, et al. Alcohol consumption and mortality among women. N Engl J Med 1995;332:1245–1250.

    Article  CAS  PubMed  Google Scholar 

  191. Willett WC. Folic acid and neural tube defect: can’t we come to closure? Am J Publ Hlth 1992;82:666–668.

    Article  CAS  Google Scholar 

  192. Giovannucci E. Epidemiologic studies of folate and colorectal neoplasia: a review. Journal of Nutrition 2002;132:2350S–2355S.

    CAS  PubMed  Google Scholar 

  193. Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med 1993;328:1444–1449.

    Article  CAS  PubMed  Google Scholar 

  194. Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993;328:1450–1456.

    Article  CAS  PubMed  Google Scholar 

  195. Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000;342:154–160.

    Article  CAS  PubMed  Google Scholar 

  196. Enstrom JE, Kanim LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population. Epidemiology 1992;3:194–202.

    Article  CAS  PubMed  Google Scholar 

  197. Osganian SK, Stampfer MJ, Rimm E, et al. Vitamin C and risk of coronary heart disease in women. J Am Coll Cardiol 2003;42:246–252.

    Article  CAS  PubMed  Google Scholar 

  198. Feskanich D, Singh V, Willett WC, Colditz GA. Vitamin A intake and hip fractures among postmenopausal women. Jama 2002;287:47–54.

    Article  CAS  PubMed  Google Scholar 

  199. Melhus H, Michaelsson K, Kindmark A, et al. Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture. Ann Intern Med 1998;129:770–778.

    CAS  PubMed  Google Scholar 

  200. Caire-Juvera G, Ritenbaugh C, Wactawski-Wende J, Snetselaar LG, Chen Z. Vitamin A and retinol intakes and the risk of fractures among participants of the Women's Health Initiative Observational Study. Am J Clin Nutr 2009;89: 323–330.

    Article  CAS  PubMed  Google Scholar 

  201. Ballew C, Galuska D, Gillespie C. High serum retinyl esters are not associated with reduced bone mineral density in the Third National Health And Nutrition Examination Survey, 1988–1994. J Bone Miner Res 2001;16:2306–2312.

    Article  CAS  PubMed  Google Scholar 

  202. Blot WJ, Li JY, Taylor PR, et al. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 1993;85:1483–1492.

    Article  CAS  PubMed  Google Scholar 

  203. Stampfer MJ, Hu FB, Manson JE, Rimm EB, Willett WC. Primary prevention of coronary heart disease in women through diet and lifestyle. N Engl J Med 2000;343:16–22.

    Article  CAS  PubMed  Google Scholar 

  204. Rothman KJ, Moore LL, Singer MR, et al. Teratogenicity of high vitamin A intake. N Engl J Med 1995;333: 1369–1373.

    Article  CAS  PubMed  Google Scholar 

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Willett, W.C. (2010). Public Health Benefits of Preventive Nutrition. In: Bendich, A., Deckelbaum, R. (eds) Preventive Nutrition. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-60327-542-2_1

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