Skip to main content

Peyronie’s Disease: Surgical Therapy

  • Chapter
  • First Online:
Contemporary Treatment of Erectile Dysfunction

Part of the book series: Contemporary Endocrinology ((COE))

  • 1028 Accesses

Abstract

Peyronie’s disease (PD) is characterized by scarring and alteration of the intricate architecture of the tunica albuguinea of the penis. This anatomic deformity may cause an abnormal penile curvature toward the site of scarring, cosmetic displease, painful erections during the active phase, and erectile dysfunction (ED) that in some may preclude sexual intercourse. The earliest descriptions of the condition in the Western literature are attributed to Guilielmus of Saliceto (1210–1276) and Theodoricus Borgognoni (1205–1298) who are said to have described penile curvature in medical and anatomical textbooks. The symptomatic incidence of PD is estimated at 1–5% while the asymptomatic incidence is at 0.4–1%, mostly affecting men 45–60 years of age with an average age of 53 years. To date, most medical and herbal therapies have achieved suboptimal penile straightening and satisfaction rates in the vast majority of patients. In those with failed medical or conservative therapies, surgical interventions have shown great promise with excellent results.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Musitelli, S., Bossi, M., & Jallous, H. (2008). A brief historical survey of “Peyronie’s disease”. The Journal of Sexual Medicine, 5(7), 1737–1746.

    Article  PubMed  Google Scholar 

  2. Peyronie, F., de la. (1743). Sur quelques obstacles qui s’opposent a l’ejaculation naturelle de la semence. Memoires de l’Academie de Chirurgie, 1, 318.

    Google Scholar 

  3. Schwarzer, U., Sommer, F., Klotz, T., Braun, M., Reifenrath, B., & Engelmann, U. (2001). The prevalence of Peyronie’s disease: Results of a large survey. BJU International, 88(7), 727–730.

    Article  CAS  PubMed  Google Scholar 

  4. Gelbard, M. K., Dorey, F., & James, K. (1990). The natural history of Peyronie’s disease. Journal d’Urologie, 144(6), 1376–1379.

    CAS  Google Scholar 

  5. Fitkin, J., & Ho, G. T. (1999). Peyronie’s disease: Current management. American Family Physician, 60(2), 549–552, 554.

    CAS  PubMed  Google Scholar 

  6. Devine, C. J., Somers, K. D., Jordan, S. G., & Schlossberg, S. M. (1997). Proposal: Trauma as the cause of the Peyronie’s lesion. Journal d’Urologie, 157, 285–290.

    Google Scholar 

  7. Carson, C. C., Jordan, G. H., & Gelbard, M. K. (1999). Peyronie’s disease: New concepts in etiology, diagnosis and treatment. Contemporary Urology, 11, 44–64.

    Google Scholar 

  8. Pryor, J. P., & Farrell, C. R. (1983). Controlled clinical trial of vitamin E in Peyronie’s disease. Program in Reproductive Biology and Medicine, 9, 41–45.

    Google Scholar 

  9. Akkus, E., Carrier, S., Rehman, J., et al. (1994). Is colchicine effective in Peyronie’s disease? A pilot study. Urology, 44, 291–295.

    Article  CAS  PubMed  Google Scholar 

  10. Hasche-Klunder, R. (1978). Treatment of Peyronie’s disease with para-aminobenzoacidic potassium (Potaba). Urology, 17, 224–227.

    CAS  Google Scholar 

  11. Weidner, W., Hauck, E. W., & Schnitker, J. (2005). Peyronie’s disease Study Group of Andrological Group of German Urologists: Potassium paraaminobenzoate (POTABA) in the treatment of Peyronie’s disease – A prospective, placebo-controlled, randomized study. European Urology, 47, 530–536.

    Article  CAS  PubMed  Google Scholar 

  12. Biagiotti, G., & Cavallini, G. (2001). Acetyl-l-carnitine vs tamoxifen in the oral therapy of Peyronie’s disease: A preliminary report. BJU International, 88, 63–67.

    Article  CAS  PubMed  Google Scholar 

  13. Cavallini, G., Biagiotti, G., Koverech, A., & Vitali, G. (2002). Oral propionyl-l-carnitine and intraplaque verapamil in the therapy of advanced and resistant Peyronie’s disease. BJU International, 89, 895–900.

    Article  CAS  PubMed  Google Scholar 

  14. Levine, L. A., Goldman, K. E., & Greenfield, J. M. (2002). Experience with intraplaque injection of verapamil for Peyronie’s disease. Journal d’Urologie, 168, 621–625. Discussion 625–626.

    CAS  Google Scholar 

  15. Gelbard, M. K., James, K., Riach, J. N., & Dorey, F. (1993). Collagenase versus placebo in the treatment of Peyronie’s disease: A double-blind study. Journal d’Urologie, 149, 56–58.

    CAS  Google Scholar 

  16. Jordan, G. H. (2007). The use of intralesional clostridial collagenase injection therapy for Peyronie’s disease: A prospective, single center, non-placebo-controlled study. The Journal of Sexual Medicine, 5(1), 180–187.

    Article  Google Scholar 

  17. Hakim, L. S., & Khater, U. (2004). Non-surgical management of Peyronie’s curvature: Experience using intralesional Intron-A therapy [abstract 72]. The Journal of Sexual Medicine, 1, 51.

    Google Scholar 

  18. Bodner, H., Howard, A. H., & Kaplan, J. H. (1954). Peyronie’s disease: Cortisone-hyaluronidase-hydrocortisone therapy. Journal d’Urologie, 72, 400–403.

    CAS  Google Scholar 

  19. Butz, M., & Teichert, H. M. (1998). Treatment of Peyronie’s disease by extracorporeal shock waves abstract. Journal d’Urologie, 159(Suppl), 118.

    Google Scholar 

  20. Brock, G., Hsu, G., & Nunes, L. (1997). The anatomy of the tunica albuginea in the normal penis and in Peyronie’s disease. Journal d’Urologie, 157, 276–281.

    CAS  Google Scholar 

  21. Moreland, R. B., & Nehra, A. (2002). Pathophysiology of Peyronie’s disease. International Journal of Impotence Research, 14, 406–410.

    Article  CAS  PubMed  Google Scholar 

  22. Van de Water, L. (1997). Mechanisms by which fibrin and fibronectin appear in healing wounds: Implications for Peyronie’s disease. Journal d’Urologie, 157, 306–310.

    Google Scholar 

  23. Somers, K. D., & Dawson, D. M. (1997). Fibrin deposition in Peyronie’s disease plaque. Journal d’Urologie, 157, 311–315.

    Article  CAS  Google Scholar 

  24. Border, W. A., & Noble, N. A. (1994). Transforming growth factor beta in tissue fibrosis. The New England Journal of Medicine, 331, 1286–1292.

    Article  CAS  PubMed  Google Scholar 

  25. Diegelmann, R. F. (1997). Cellular and biochemical aspects of normal and abnormal wound healing: An overview. Journal d’Urologie, 157, 298–302.

    Article  CAS  Google Scholar 

  26. Pryor, J. P., & Ralph, D. J. (2002). Clinical presentation of Peyronie’s disease. International Journal of Impotence Research, 14, 414–417.

    Article  CAS  PubMed  Google Scholar 

  27. Tran, V. Q., Kim, D. H., Lesser, T. F., & Aboseif, S. R. (2008). Review of surgical approaches for Peyronie’s disease: Corporal plication and plaque incision with grafting. Advances in Urology; ID 263450, 4 pages. doi:10.1155/2008/263450.

    Google Scholar 

  28. Pryor, J. P., & Fitzpatrick, J. M. (1979). A new approach to the correction of the penile deformity in Peyronie’s disease. Journal d’Urologie, 122, 622.

    CAS  Google Scholar 

  29. Nesbit, R. M. (1965). Congenital curvature of the phallus: Report of three cases with description of corrective operation. Journal d’Urologie, 93, 230–232.

    CAS  Google Scholar 

  30. Andrews, H. O., Al-Akraa, M., Pryor, J. P., & Ralph, D. J. (2001). The Nesbit operation for Peyronie’s disease: An analysis of the failures. BJU International, 87(7), 658–660.

    Article  CAS  PubMed  Google Scholar 

  31. Licht, M., & Lewis, R. W. (1997). Modified Nesbit procedure for the treatment of Peyronie’s disease: A comparative outcome analysis. Journal d’Urologie, 158, 460–463.

    CAS  Google Scholar 

  32. Essed, E., & Schroeder, F. H. (1985). New surgical treatment for Peyronie’s disease. Urology, 25(6), 582–587.

    Article  CAS  PubMed  Google Scholar 

  33. Lue, T. F., & Deng, D. Y. (2003). The 16-dot procedure for penile placation. Atlas of the Urological Clinics of North America, 11, 65–72.

    Google Scholar 

  34. Kalsi, J., Minhas, S., Christopher, N., & Ralph, D. (2005). The results of plaque incision and venous grafting (Lue procedure) to correct the penile deformity of Peyronie’s disease. BJU International, 95(7), 1029–1033.

    Article  PubMed  Google Scholar 

  35. Montorsi, F., Salonia, A., Maga, T., et al. (2000). Evidence based assessment of long-term results of plaque incision and vein grafting for Peyronie’s disease. Journal d’Urologie, 163(6), 1704–1708.

    CAS  Google Scholar 

  36. Carson, G. C. (2000). Penile prosthesis implantation in the treatment of Peyronie’s disease and erectile dysfunction. International Journal of Impotence Research, 12, S122–S126.

    Article  PubMed  Google Scholar 

  37. Mulcahy, J. J., & Wilson, S. K. (2002). Management of Peyronie’s disease with penile prostheses. International Journal of Impotence Research, 14, 384–388.

    Article  CAS  PubMed  Google Scholar 

  38. Carson, G. C. (1998). Penile prosthesis implantation in the treatment of Peyronie’s disease. International Journal of Impotence Research, 10, 125–128.

    Article  CAS  PubMed  Google Scholar 

  39. Montorsi, F., Guazzoni, G., Barbieri, L., et al. (1996). AMS 700CX in inflatable penile implants for Peyronie’s disease: Functional results, morbidity, and patient-partner satisfaction. International Journal of Impotence Research, 8, 81–85.

    CAS  PubMed  Google Scholar 

  40. Levine, L. A., & Dimitriou, R. J. (2000). A surgical algorithm for penile prosthesis placement in men with erectile failure and Peyronie’s disease. International Journal of Impotence Research, 12, 147–151.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Peter R. Hinds .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Hinds, P.R., Sadeghi-Nejad, H. (2011). Peyronie’s Disease: Surgical Therapy. In: McVary, K. (eds) Contemporary Treatment of Erectile Dysfunction. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-60327-536-1_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-60327-536-1_17

  • Published:

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-535-4

  • Online ISBN: 978-1-60327-536-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics