Skip to main content
SpringerLink
Log in
Book cover

Infectious Disease in the Aging pp 435–453Cite as

Vaccinations

  • Chapter
  • First Online:

Part of the book series: Infectious Disease ((ID))

Abstract

People with advanced age experience greater morbidity and mortality from infectious diseases, due, in part, to immunosenescence.

Older and vaccinated individuals present with attenuated symptoms and signs in many infections.

When infection still occurs, vaccination remains cost effective to prevent infectious diseases or attenuate morbidity and mortality.

Vaccination rates >80% reduce spread, morbidity, and mortality of some infections through herd immunity.

Influenza, pneumococcal, tetanus/diphtheria, and herpes-zoster vaccinations are recommended for elders.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

References

  1. Castle, S.C., Uyemura, K., Fulop, T., Makinodan, T. (2007). Host resistance and immune responses in advanced age. Clinics in Geriatric Medicine, 23(3), 463–479.

    Article  PubMed  Google Scholar 

  2. Aspinall, R., Del Giudice, G., Effros, R.B., Grubeck-Loebenstein, B., Sambhara, S. (2007). Challenges for vaccination in the elderly. Immune Ageing, 7, 4–9.

    Google Scholar 

  3. Stoll, G., Bendszus, M. (2006). Inflammation and atherosclerosis: novel insights into plaque formation and destabilization. Stroke, 37(7), 1923–1932.

    Article  PubMed  CAS  Google Scholar 

  4. Solenski, N.J. (2007). Emerging risk factors for cerebrovascular disease. Current Drug Targets, 8(7), 802–816.

    Article  PubMed  CAS  Google Scholar 

  5. Grau, A.J., Marquardt, L., Lichy, C. (2006). The effect of infections and vaccinations on stroke risk. Expert Review in Neurotherapy, 6(2), 175–183.

    Article  Google Scholar 

  6. Lichy, C., Grau, A.J. (2006). Investigating the association between influenza vaccination and reduced stroke risk. Expert Review Vaccines, 5(4), 535–540.

    Article  Google Scholar 

  7. Armstrong, E.P. (2007). Economic benefits and costs associated with target vaccinations. Journal of Managed Care Pharmacy, 13(7 Suppl. B), S12–S15.

    PubMed  Google Scholar 

  8. Drummond, M., Chevat, C., Lothgren, M. (2007). Do we fully understand the economic value of vaccines? Vaccine, 25(32), 5945–5957.

    Article  PubMed  Google Scholar 

  9. Zimmerman, R.K., Middleton, D.B., Burns, I.T., Clover, R.D., Kimmel, S.R. (2007). Routine vaccines across the life span, 2007. Journal of Family Practice, 56 (Suppl. Vaccines), S18–S37, C1–3.

    PubMed  Google Scholar 

  10. Sand, K.L., Lynn, J., Bardenheier, B., Seow, H., Nace, D.A. (2007). Increasing influenza immunization for long-term care facility staff using quality improvement. Journal of the American Geriatrics Society, 55(11), 1741–1747.

    Article  Google Scholar 

  11. Zielinski, A. (2007). Tetanus in 2005. Przegl Epidemiology, 61(2), 287–289.

    Google Scholar 

  12. Fiscella, K., Dressler, R., Meldrum, S., Holt, K. (2007). Impact of influenza vaccination disparities on elderly mortality in the United States. Preventive Medicine, 45(1), 83–87.

    Article  PubMed  Google Scholar 

  13. Belshe, R.B. (2007). The burden of influenza and strategies for prevention. Managed Care, 16(Supp. 8), 2–6; 17–19.

    PubMed  Google Scholar 

  14. Nichol, K.L., Nordin, J., Mullooly, J., Lask, R., Fillbrandt, K., Iwane, M. (2003). Influenza vaccination and reduction in hospitalizations for cardiac disease and stroke among the elderly. New England Journal of Medicine, 348(14), 1322–1332.

    Article  PubMed  Google Scholar 

  15. Nichol, K.L., Nordin, J.D., Nelson, D.B., Mullooly, J.P., Hak, E. (2007). Effectiveness of influenza vaccine in the community-dwelling elderly. New England Journal of Medicine, 357(14), 1373–1381.

    Article  PubMed  CAS  Google Scholar 

  16. Tang, J.W., Ngai, K.L., Wong, J.C., Lam, W.Y., Chan, P.K. (2008). Emergence of adamantane-resistant influenza A(H3N2) viruses in Hong Kong between 1997 and 2006. Journal of Medical Virology, 80(5), 895–901.

    Article  PubMed  CAS  Google Scholar 

  17. Saito, R., Suzuki, Y., Li, D., Zaraket, H., Sato, I., Masaki, H., et al (2008). Increased incidence of adamantane-resistant influenza A(H1N1) and A(H3N2) viruses during the 2006–2007 influenza season in Japan. Journal of Infectious Diseases, 197(4), 630–632; (author reply, 632–633).

    Article  PubMed  Google Scholar 

  18. Escuret, V., Frobert, E., Bouscambert-Duchamp, M., Sabatier, M., Grog, I., Valette, M., et al (2008). Detection of human influenza A (H1N1) and B strains with reduced sensitivity to neuraminidase inhibitors. Journal of Clinical Virology, 41(1), 25–28.

    Article  PubMed  CAS  Google Scholar 

  19. Smith, N.M., Bresee, J.S., Shay, D.K., Uyeki, T.M., Cox, N.J., Strikas, R.A. (2006). Prevention and Control of Influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). (Mort Morb Wkly Rep, 55(RR-10), 1–42).

    Google Scholar 

  20. Liu, Y., Wang, H., Chen, M., Sun, Z., Zhao, R., Zhang, L., et al (2008). Serotype distribution and antimicrobial resistance patterns of Streptococcus pneumoniae isolated from children in China younger than 5 years. Diagnostic Microbiology and Infectious Diseases, 61, 256–263.

    Article  CAS  Google Scholar 

  21. Middleton, D.B., Zimmerman, R.K., Mitchell, K.B. (2007). Vaccine schedules and procedures, 2007. Journal of Family Practice, 56(2 Suppl. Vaccines), S47–S60; C4–C8.

    PubMed  Google Scholar 

  22. Chi, R.C., Jackson, L.A., Neuzil, K.M. (2006). Characteristics and outcomes of older adults with community-acquired pneumococcal bacteremia. Journal of the American Geriatrics Society, 54(1), 115–120.

    Article  PubMed  Google Scholar 

  23. Gable, C.B., Holzer, S.S., Engelhart, L., Friedman, R.B., Smeltz, F., Schroeder, D., et al (1990). Pneumococcal vaccine. Efficacy and associated cost savings. Journal of the American Medical Association, 264(22), 2910–2915.

    Article  PubMed  CAS  Google Scholar 

  24. Simberkoff, M.S., Cross, A.P., Al-Ibrahim, M., Baltch, A.L., Geiseler, P.J., Nadler, J., et al (1986). Efficacy of pneumococcal vaccine in high-risk patients. Results of a Veterans Administration Cooperative Study. New England Journal of Medicine, 315(21), 1318–1327.

    Article  PubMed  CAS  Google Scholar 

  25. Koivula, I., Sten, M., Makela, P.H. (1999). Prognosis after community-acquired pneumonia in the elderly: a population-based 12-year follow-up study. Archives of Internal Medicine, 159(14), 1550–1555.

    Article  PubMed  CAS  Google Scholar 

  26. http://www.jr2.ox.ac.uk/bandolier/band72/b72-4.html/ (Retrieved on April 21, 2008).

  27. Centers for Disease Control and Prevention. Recommended adult immunization schedule – United States, 2009 MMWR 2008; 57(53), Q1–Q4.

    Google Scholar 

  28. Oxman, M.N., Levin, M.J., Johnson, G.R., Schmader, K.E., Straus, S.E., Gelb, L.D., et al (2005). A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. New England Journal of Medicine, 352(22), 2271–2284.

    Article  PubMed  CAS  Google Scholar 

  29. Hornberger, J., Robertus, K. (2006). Cost-effectiveness of a vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. Annals of Internal Medicine, 145(5), 317–325.

    PubMed  Google Scholar 

  30. Zostiax. (2005). FDA clinical briefing document for Merck and Co.

    Google Scholar 

  31. Pellissier, J.M., Brisson, M., Levin, M.J. (2007). Evaluation of the cost-effectiveness in the United States of a vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. Vaccine, 25(49), 8326–8337.

    Article  PubMed  Google Scholar 

  32. Potter, J., Stott, D.J., Roberts, M.A., Elder, A.G., O’Donnell, B., Knight, P.V., et al. (1997). Influenza vaccination of health care workers in long-term-care hospitals reduces the mortality of elderly patients. Journal of Infectious Diseases, 175(1), 1–6.

    Article  PubMed  CAS  Google Scholar 

Suggested Reading

  • Castle, S.C., Uyemura, K., Fulop, T., Makinodan, T. (2007). Host resistance and immune responses in advanced age. Clinics in Geriatric Medicine, 23(3), 463–479.

    Article  PubMed  Google Scholar 

  • Targonski, P.V., Jacobson, R.M., Poland, G.A. (2007). Immunosenescence: role and measurement in influenza vaccine response among the elderly. Vaccine, 25(16), 3066–3099.

    Article  PubMed  CAS  Google Scholar 

  • Zimmerman, R.K., Middleton, D.B., Burns, I.T., Clover, R.D., Kimmel, S.R. (2007). Routine vaccines across the life span, 2007. Journal of Family Practice, 56(2 Suppl. Vaccines), S18–S37; C1–C3.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Alpert Medical School of Brown University and Quality Partners of Rhode Island, 235 Promenade Street, Suite 500, Providence, RI, 02908, USA

    Rex Biedenbender & Stefan Gravenstein

Authors
  1. Rex Biedenbender
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stefan Gravenstein
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stefan Gravenstein .

Editor information

Editors and Affiliations

    Rights and permissions

    Reprints and permissions

    Copyright information

    © 2009 Humana Press, a part of Springer Science+Business Media, LLC

    About this chapter

    Cite this chapter

    Biedenbender, R., Gravenstein, S. (2009). Vaccinations. In: Norman, D., Yoshikawa, T. (eds) Infectious Disease in the Aging. Infectious Disease. Humana Press. https://doi.org/10.1007/978-1-60327-534-7_27

    Download citation

    • DOI: https://doi.org/10.1007/978-1-60327-534-7_27

    • Published:

    • Publisher Name: Humana Press

    • Print ISBN: 978-1-60327-533-0

    • Online ISBN: 978-1-60327-534-7

    • eBook Packages: MedicineMedicine (R0)

    Publish with us

    Policies and ethics

    Search

    Navigation